BCAS3

BCAS3
Identifiers
Aliases	BCAS3 , GAOB1, MAAB, breast carcinoma amplified sequence 3, microtubule associated cell migration factor, BCAS3 microtubule associated cell migration factor, PHAF2, HEMARS
External IDs	OMIM: 607470; MGI: 2385848; HomoloGene: 9778; GeneCards: BCAS3; OMA:BCAS3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q23.2 Start 60,677,453 bp [1] End 61,392,838 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 C Start 85,353,167 bp [2] End 85,826,058 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon sural nerve right uterine tube bone marrow cells Achilles tendon prefrontal cortex testicle olfactory zone of nasal mucosa right coronary artery popliteal artery Top expressed in seminal vesicula morula muscle of thigh neural layer of retina superior frontal gyrus dentate gyrus of hippocampal formation granule cell genital tubercle blastocyst lip yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding chromatin binding acetyltransferase activator activity beta-tubulin binding histone acetyltransferase binding transcription factor binding protein binding Cellular component intermediate filament cytoskeleton nucleolus cell periphery cell leading edge cytoplasmic microtubule cytoskeleton nucleus cytoplasm Biological process angiogenesis cellular response to estrogen stimulus positive regulation of endothelial cell migration positive regulation of GTPase activity positive regulation of intracellular protein transport transcription, DNA-templated positive regulation of actin cytoskeleton reorganization microtubule organizing center organization negative regulation of focal adhesion assembly response to starvation activation of GTPase activity Golgi organization regulation of establishment of cell polarity tube formation regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of GTPase activity positive regulation of catalytic activity positive regulation of filopodium assembly vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54828 192197 Ensembl ENSG00000141376 ENSMUSG00000059439 UniProt Q9H6U6 Q8CCN5 RefSeq (mRNA) NM_001099432 NM_017679 NM_001320470 NM_001330413 NM_001330414 NM_001353144 NM_001353145 NM_001353146 NM_001166642 NM_001166643 NM_138681 RefSeq (protein) NP_001092902 NP_001307399 NP_001317342 NP_001317343 NP_060149 NP_001340073 NP_001340074 NP_001340075 NP_001160114 NP_001160115 NP_619622 Location (UCSC) Chr 17: 60.68 – 61.39 Mb Chr 11: 85.35 – 85.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene. ^{[5] [6]} BCAS3 is a gene that is amplified and overexpressed in breast cancer cells. ^[6]

Function

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α). ^[7] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α. ^{[8] [ better source needed ]} Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification. ^{[8] [ better source needed ]}

References

1. GRCh38: Ensembl release 89: ENSG00000141376 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059439 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3".
6. Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A (December 2002). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID   12378525. S2CID   9759638.
7. Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R (April 2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. Bibcode:2006PNAS..103.6670G. doi: 10.1073/pnas.0601989103 . PMC   1458939 . PMID   16617102.
8. Gururaj AE, Peng S, Vadlamudi RK, Kumar R (August 2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi: 10.1210/me.2006-0514 . PMID   17505058. (Retracted, see doi:10.1210/me.2014-1149,  Retraction Watch)

External links

• Human BCAS3 genome location and BCAS3 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Bärlund M, Monni O, Weaver JD, et al. (2003). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID   12378525. S2CID   9759638.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Gururaj AE, Singh RR, Rayala SK, et al. (2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. Bibcode:2006PNAS..103.6670G. doi: 10.1073/pnas.0601989103 . PMC   1458939 . PMID   16617102.
• Gururaj AE, Holm C, Landberg G, Kumar R (2006). "Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer". Cell Cycle. 5 (13): 1407–10. doi: 10.4161/cc.5.13.2924 . PMID   16855396.
• Gururaj AE, Peng S, Vadlamudi RK, Kumar R (2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi: 10.1210/me.2006-0514 . PMID   17505058. (Retracted, see doi:10.1210/me.2014-1149,  Retraction Watch)