NCOA6

NCOA6
Identifiers
Aliases	NCOA6 , AIB3, ASC2, NRC, PRIP, RAP250, TRBP, nuclear receptor coactivator 6
External IDs	OMIM: 605299; MGI: 1929915; HomoloGene: 40920; GeneCards: NCOA6; OMA:NCOA6 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.22 Start 34,689,097 bp [1] End 34,825,651 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 155,232,576 bp [2] End 155,315,814 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ganglionic eminence tibia epithelium of nasopharynx gingival epithelium parietal pleura pancreatic ductal cell visceral pleura ventricular zone urethra Top expressed in zygote secondary oocyte genital tubercle tail of embryo spermatocyte retinal pigment epithelium vestibular sensory epithelium primary oocyte stroma of bone marrow ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding protein binding enzyme binding estrogen receptor binding retinoid X receptor binding nuclear receptor coactivator activity thyroid hormone receptor binding transcription coactivator activity Cellular component intracellular membrane-bounded organelle transcription regulator complex nucleoplasm nucleus histone methyltransferase complex cytosol Biological process myeloid cell differentiation DNA recombination regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus positive regulation of transcription, DNA-templated DNA replication heart development brain development DNA-templated transcription, initiation response to hormone DNA repair intracellular estrogen receptor signaling pathway glucocorticoid receptor signaling pathway positive regulation of transcription by RNA polymerase II regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23054 56406 Ensembl ENSG00000198646 ENSMUSG00000038369 UniProt Q14686 Q9JL19 RefSeq (mRNA) NM_001242539 NM_014071 NM_001318240 NM_001242558 NM_019825 RefSeq (protein) NP_001229468 NP_001305169 NP_054790 n/a Location (UCSC) Chr 20: 34.69 – 34.83 Mb Chr 2: 155.23 – 155.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D₃, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases. ^[7]

Interactions

NCOA6 has been shown to interact with:

• ASCL2 ^[8] and
• Activating transcription factor 2, ^[9]
• Androgen receptor, ^[10]
• CREB-binding protein, ^{[11] [12]}
• DNA-PKcs, ^[13]
• E2F1, ^[14]
• EP300, ^[13]
• Estrogen receptor alpha, ^{[11] [15]}
• Estrogen receptor beta, ^{[12] [15]}
• HBXIP, ^[16]
• HIST2H3C, ^[8]
• HSF1, ^[17]
• Ku70, ^{[13] [18]}
• Ku80, ^{[13] [18]}
• Liver X receptor beta, ^[12]
• MLL3, ^[8]
• RBBP5, ^[8]
• Retinoblastoma protein, ^[10]
• Retinoic acid receptor alpha, ^{[11] [12] [13]}
• Retinoid X receptor alpha, ^{[11] [12] [15] [16]}
• Src, ^{[8] [11] [12] [19]}
• TGS1, ^{[20] [21]}
• TUBA4A, ^[8]
• TUBB, ^[8]
• Thyroid hormone receptor alpha, ^{[11] [19]} and
• Thyroid hormone receptor beta. ^{[11] [12] [13] [15]}

See also

• Transcription coregulator

References

1. GRCh38: Ensembl release 89: ENSG00000198646 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038369 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (November 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi: 10.1093/dnares/3.1.17 . PMID   8724849.
6. Estey A, Kemp M, Allison S, Lamb C (January 1994). "Evaluation of a patient information booklet". J Nurs Staff Dev. 9 (6): 278–82. PMID   8263591.
7. "Entrez Gene: NCOA6 nuclear receptor coactivator 6".
8. Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (January 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. 23 (1): 140–9. doi:10.1128/mcb.23.1.140-149.2003. PMC   140670 . PMID   12482968.
9. Hong S, Choi HM, Park MJ, Kim YH, Choi YH, Kim HH, Choi YH, Cheong J (April 2004). "Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid". J. Biol. Chem. 279 (17): 16996–7003. doi: 10.1074/jbc.M311752200 . PMID   14734562.
10. Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW (February 2004). "Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation". J. Biol. Chem. 279 (8): 7131–5. doi: 10.1074/jbc.M312563200 . PMID   14645241.
11. Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (November 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi: 10.1074/jbc.274.48.34283 . PMID   10567404.
12. Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (February 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. doi: 10.1210/mend.15.2.0595 . PMID   11158331.
13. Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. Bibcode:2000PNAS...97.6212K. doi: 10.1073/pnas.97.11.6212 . PMC   18584 . PMID   10823961.
14. Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J (November 2003). "Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation". Mol. Cancer Res. 1 (13): 948–58. PMID   14638867.
15. Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW (January 2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. doi: 10.1210/mend.16.1.0755 . PMID   11773444.
16. Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi: 10.1053/jhep.2003.50451 . PMID   14578865. S2CID   29349615.
17. Hong S, Kim SH, Heo MA, Choi YH, Park MJ, Yoo MA, Kim HD, Kang HS, Cheong J (February 2004). "Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock". FEBS Lett. 559 (1–3): 165–70. Bibcode:2004FEBSL.559..165H. doi: 10.1016/S0014-5793(04)00028-6 . PMID   14960326. S2CID   22383479.
18. Ko L, Chin WW (March 2003). "Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase". J. Biol. Chem. 278 (13): 11471–9. doi: 10.1074/jbc.M209723200 . PMID   12519782.
19. Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (June 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. 14 (6): 915–25. doi: 10.1210/mend.14.6.0471 . PMID   10847592.
20. Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi: 10.1074/jbc.M201739200 . PMID   11912212.
21. Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (August 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10380–5. Bibcode:2001PNAS...9810380Z. doi: 10.1073/pnas.181347498 . PMC   56969 . PMID   11517327.

Further reading

• Mahajan MA, Samuels HH (July 2000). "A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein". Mol. Cell. Biol. 20 (14): 5048–63. doi:10.1128/MCB.20.14.5048-5063.2000. PMC   85955 . PMID   10866662.
• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Carney JP, McKnight C, VanEpps S, Kelley MR (1995). "Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats". Gene. 155 (2): 289–92. doi:10.1016/0378-1119(94)00758-K. PMID   7536696.
• Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS (1996). "Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer". Cancer Res. 56 (15): 3446–50. PMID   8758910.
• Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi: 10.1074/jbc.274.48.34283 . PMID   10567404.
• Caira F, Antonson P, Pelto-Huikko M, Treuter E, Gustafsson JA (2000). "Cloning and characterization of RAP250, a novel nuclear receptor coactivator". J. Biol. Chem. 275 (8): 5308–17. doi: 10.1074/jbc.275.8.5308 . PMID   10681503.
• Zhu Y, Kan L, Qi C, Kanwar YS, Yeldandi AV, Rao MS, Reddy JK (2000). "Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR". J. Biol. Chem. 275 (18): 13510–6. doi: 10.1074/jbc.275.18.13510 . PMID   10788465.
• Ko L, Cardona GR, Chin WW (2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. Bibcode:2000PNAS...97.6212K. doi: 10.1073/pnas.97.11.6212 . PMC   18584 . PMID   10823961.
• Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. 14 (6): 915–25. doi: 10.1210/mend.14.6.0471 . PMID   10847592.
• Mahajan MA, Samuels HH (2000). "A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein". Mol. Cell. Biol. 20 (14): 5048–63. doi:10.1128/MCB.20.14.5048-5063.2000. PMC   85955 . PMID   10866662.
• Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. doi: 10.1210/mend.15.2.0595 . PMID   11158331.
• Hong S, Lee MY, Cheong J (2001). "Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell". Biochem. Biophys. Res. Commun. 282 (5): 1257–62. doi:10.1006/bbrc.2001.4727. PMID   11302752.
• Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi: 10.1074/jbc.M101517200 . PMID   11443112.
• Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10380–5. Bibcode:2001PNAS...9810380Z. doi: 10.1073/pnas.181347498 . PMC   56969 . PMID   11517327.
• Jung DJ, Na SY, Na DS, Lee JW (2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi: 10.1074/jbc.M110417200 . PMID   11704680.
• Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW (2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. doi: 10.1210/mend.16.1.0755 . PMID   11773444.
• Qi C, Chang J, Zhu Y, Yeldandi AV, Rao SM, Zhu YJ (2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32): 28624–30. doi: 10.1074/jbc.M201053200 . PMID   12039952.
• Espejo F, Green M, Preece NE, Assa-Munt N (2003). "NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation". J. Biomol. NMR. 23 (2): 151–2. doi:10.1023/A:1016398403157. PMID   12153040. S2CID   40822239.

External links

• NCOA6 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C94

This article incorporates text from the United States National Library of Medicine, which is in the public domain.