HBXIP

Last updated
LAMTOR5
Protein HBXIP PDB 3MS6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LAMTOR5 , HBXIP, XIP, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
External IDs OMIM: 608521 MGI: 1915826 HomoloGene: 4668 GeneCards: LAMTOR5
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006402
NM_001382293

NM_026774

RefSeq (protein)

NP_006393
NP_001369222
NP_006393.2

NP_081050

Location (UCSC) Chr 1: 110.4 – 110.41 Mb Chr 3: 107.19 – 107.19 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene. [5] [6]

Contents

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [6]

Interactions

HBXIP has been shown to interact with NCOA6. [7]

Related Research Articles

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<span class="mw-page-title-main">MYBL2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">NCOA6</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">HBx</span>

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The transactivation domain or trans-activating domain (TAD) is a transcription factor scaffold domain which contains binding sites for other proteins such as transcription coregulators. These binding sites are frequently referred to as activation functions (AFs). TADs are named after their amino acid composition. These amino acids are either essential for the activity or simply the most abundant in the TAD. Transactivation by the Gal4 transcription factor is mediated by acidic amino acids, whereas hydrophobic residues in Gcn4 play a similar role. Hence, the TADs in Gal4 and Gcn4 are referred to as acidic or hydrophobic, respectively.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134248 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000087260 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Melegari M, Scaglioni PP, Wands JR (March 1998). "Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication". Journal of Virology. 72 (3): 1737–43. doi:10.1128/jvi.72.3.1737-1743.1998. PMC   109461 . PMID   9499022.
  6. 1 2 "Entrez Gene: HBXIP hepatitis B virus x interacting protein".
  7. Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi: 10.1053/jhep.2003.50451 . PMID   14578865.

Further reading