RCOR1

RCOR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IW5, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48, 3ZMS, 3ZMT, 3ZMU, 3ZMV, 3ZMZ, 3ZN0, 3ZN1, 4BAY, 4KUM, 4UV8, 4UV9, 4UVA, 4UVB, 4UVC, 4UXN, 5L3D, 5L3B, 5L3C, 4XBF
Identifiers
Aliases	RCOR1 , COREST, RCOR, REST corepressor 1
External IDs	OMIM: 607675; MGI: 106340; HomoloGene: 32246; GeneCards: RCOR1; OMA:RCOR1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.31-q32.32 Start 102,592,649 bp [1] End 102,730,561 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 F1|12 60.93 cM Start 111,005,785 bp [2] End 111,082,335 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gums gingival epithelium bone marrow mucosa of pharynx palpebral conjunctiva bone marrow cells jejunal mucosa skin of thigh human penis Top expressed in hair follicle Gonadal ridge epithelium of stomach human fetus left lung lobe left colon atrium crypt of lieberkuhn of small intestine Paneth cell saccule More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding transcription factor binding histone deacetylase activity transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component DNA repair complex transcription repressor complex nucleus transcription regulator complex nucleoplasm Biological process histone H4 deacetylation viral process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated blood coagulation transcription, DNA-templated negative regulation of transcription by RNA polymerase II chromatin organization regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23186 217864 Ensembl ENSG00000089902 ENSMUSG00000037896 UniProt Q9UKL0 Q8CFE3 RefSeq (mRNA) NM_015156 NM_198023 RefSeq (protein) NP_055971 NP_932140 Location (UCSC) Chr 14: 102.59 – 102.73 Mb Chr 12: 111.01 – 111.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene. ^{[5] [6]}

Function

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). ^[6]

Interactions

RCOR1 has been shown to interact with

• HDAC1, ^{[7] [8]}
• HDAC2, ^{[7] [8]}
• HMG20B, ^[7]
• REST ^[5] and
• PHF21A. ^{[7] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000089902 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037896 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9873–8. Bibcode:1999PNAS...96.9873A. doi: 10.1073/pnas.96.17.9873 . PMC   22303 . PMID   10449787.
6. "Entrez Gene: RCOR1 REST corepressor 1".
7. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi: 10.1073/pnas.112008599 . PMC   124246 . PMID   12032298.
8. You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. Bibcode:2001PNAS...98.1454Y. doi: 10.1073/pnas.98.4.1454 . PMC   29278 . PMID   11171972.
9. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID   15325272.

Further reading

• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID   7584044.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T (2000). "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex". J. Biol. Chem. 275 (13): 9461–7. doi: 10.1074/jbc.275.13.9461 . PMID   10734093.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1". J. Biol. Chem. 276 (9): 6817–24. doi: 10.1074/jbc.M007372200 . PMID   11102443.
• You A, Tong JK, Grozinger CM, Schreiber SL (2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. Bibcode:2001PNAS...98.1454Y. doi: 10.1073/pnas.98.4.1454 . PMC   29278 . PMID   11171972.
• Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G (2001). "Regulation of neuronal traits by a novel transcriptional complex". Neuron. 31 (3): 353–65. doi: 10.1016/S0896-6273(01)00371-3 . PMID   11516394.
• Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi: 10.1073/pnas.112008599 . PMC   124246 . PMID   12032298.
• Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex". J. Biol. Chem. 277 (43): 41038–45. doi: 10.1074/jbc.M205691200 . PMID   12192000.
• Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG (2002). "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes". Science. 298 (5599): 1747–52. Bibcode:2002Sci...298.1747L. CiteSeerX   10.1.1.136.7131 . doi:10.1126/science.1076469. PMID   12399542. S2CID   13507921.
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. doi: 10.1074/jbc.M208992200 . PMID   12493763.
• Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID   15325272.
• Gu H, Liang Y, Mandel G, Roizman B (2005). "Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7571–6. Bibcode:2005PNAS..102.7571G. doi: 10.1073/pnas.0502658102 . PMC   1140450 . PMID   15897453.
• Lee MG, Wynder C, Cooch N, Shiekhattar R (2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature. 437 (7057): 432–5. Bibcode:2005Natur.437..432L. doi:10.1038/nature04021. PMID   16079794. S2CID   4396351.
• Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell. 19 (6): 857–64. doi: 10.1016/j.molcel.2005.08.027 . PMID   16140033.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.