| PNRC1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | PNRC1 , B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606714 MGI: 1917838 HomoloGene: 4960 GeneCards: PNRC1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene. [5] [6]
PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR. [7] [8] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1. [8]
In molecular biology and genetics, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes. Transcription coregulators that activate gene transcription are referred to as coactivators while those that repress are known as corepressors. The mechanism of action of transcription coregulators is to modify chromatin structure and thereby make the associated DNA more or less accessible to transcription. In humans several dozen to several hundred coregulators are known, depending on the level of confidence with which the characterisation of a protein as a coregulator can be made. One class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP dependent class modifies the conformation of chromatin.
Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.
Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.
Tubulin beta-4A chain is a protein that in humans is encoded by the TUBB4A gene. Two tubulin beta-4 chain proteins are encoded in the human genome by the genes TUBB4A and TUBB4B. Tubulin is the major constituent of microtubules, a key components of the cytoskeleton. It binds two molecules of GTP, one at an exchangeable site on the beta-chain and one at a non-exchangeable site on the alpha-chain. TUBB4A is preferentially and highly expressed in the central nervous system.
Nuclear receptor coactivator 7 is a protein that in humans is encoded by the NCOA7 gene.
Olfactory receptor 2C1 is a protein that in humans is encoded by the OR2C1 gene.
Olfactory receptor 12D3 is a protein that in humans is encoded by the OR12D3 gene.
Olfactory receptor 5V1 is a protein that in humans is encoded by the OR5V1 gene.
Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene.
Transcription factor AP-4 , also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.
TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene.
Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.
Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene. BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.
Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene.
Proline-rich nuclear receptor coactivator 2 is a protein that in humans is encoded by the PNRC2 gene.
DnaJ homolog subfamily C member 14 is a protein that in humans is encoded by the DNAJC14 gene.
Eukaryotic translation elongation factor 1 epsilon-1 is a protein that in humans is encoded by the EEF1E1 gene.
WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene.
Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.
Probable G-protein coupled receptor 61 is a protein that in humans is encoded by the GPR61 gene.
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