PNRC1

Last updated
PNRC1
Identifiers
Aliases PNRC1 , B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1
External IDs OMIM: 606714 MGI: 1917838 HomoloGene: 4960 GeneCards: PNRC1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006813

NM_001033225

RefSeq (protein)

NP_006804

NP_001028397

Location (UCSC) Chr 6: 89.08 – 89.09 Mb Chr 4: 33.25 – 33.29 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene. [5] [6]

Contents

Function

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR. [7] [8] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1. [8]

Related Research Articles

In molecular biology and genetics, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes. Transcription coregulators that activate gene transcription are referred to as coactivators while those that repress are known as corepressors. The mechanism of action of transcription coregulators is to modify chromatin structure and thereby make the associated DNA more or less accessible to transcription. In humans several dozen to several hundred coregulators are known, depending on the level of confidence with which the characterisation of a protein as a coregulator can be made. One class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP dependent class modifies the conformation of chromatin.

<span class="mw-page-title-main">TRIM24</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PPARGC1B</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Tubulin beta-4A chain</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">NCOA7</span> Protein-coding gene in the species Homo sapiens

Nuclear receptor coactivator 7 is a protein that in humans is encoded by the NCOA7 gene.

<span class="mw-page-title-main">OR2C1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 2C1 is a protein that in humans is encoded by the OR2C1 gene.

<span class="mw-page-title-main">OR12D3</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 12D3 is a protein that in humans is encoded by the OR12D3 gene.

<span class="mw-page-title-main">OR5V1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 5V1 is a protein that in humans is encoded by the OR5V1 gene.

<span class="mw-page-title-main">GABRR2</span> Protein-coding gene in the species Homo sapiens

Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene.

<span class="mw-page-title-main">TFAP4</span> Protein-coding gene in the species Homo sapiens

Transcription factor AP-4 , also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.

<span class="mw-page-title-main">TMF1</span> Protein-coding gene in the species Homo sapiens

TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene.

<span class="mw-page-title-main">PSCDBP</span> Protein-coding gene in the species Homo sapiens

Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.

<span class="mw-page-title-main">BCAS3</span> Protein-coding gene in the species Homo sapiens

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene. BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.

<span class="mw-page-title-main">PRB3</span> Protein-coding gene in the species Homo sapiens

Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene.

<span class="mw-page-title-main">PNRC2</span> Protein-coding gene in the species Homo sapiens

Proline-rich nuclear receptor coactivator 2 is a protein that in humans is encoded by the PNRC2 gene.

<span class="mw-page-title-main">DNAJC14</span> Protein-coding gene in the species Homo sapiens

DnaJ homolog subfamily C member 14 is a protein that in humans is encoded by the DNAJC14 gene.

<span class="mw-page-title-main">EEF1E1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation elongation factor 1 epsilon-1 is a protein that in humans is encoded by the EEF1E1 gene.

<span class="mw-page-title-main">WBP4</span> Protein-coding gene in the species Homo sapiens

WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene.

<span class="mw-page-title-main">NCOA5</span> Gene of the species Homo sapiens

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.

<span class="mw-page-title-main">GPR61</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 61 is a protein that in humans is encoded by the GPR61 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000146278 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040128 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta. 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID   7578250.
  6. "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1".
  7. Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi: 10.1210/mend.14.7.0480 . PMID   10894149.
  8. 1 2 Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC   60244 . PMID   11574675.

Further reading