LCOR

LCOR
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2COB
Identifiers
Aliases	LCOR , MLR2, ligand dependent nuclear receptor corepressor, C10orf12
External IDs	OMIM: 607698 HomoloGene: 22914 GeneCards: LCOR
Gene location (Human)
Chr.	Chromosome 10 (human)
End	96,995,956 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; visceral pleura; ; cardia; ; pylorus; ; renal medulla; ; nipple; ; inferior ganglion of vagus nerve; ; bronchial epithelial cell; ; parietal pleura;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ; protein binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ; transcription factor binding ;
Cellular component	nucleus ; nucleoplasm ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; regulation of transcription by RNA polymerase II ; negative regulation of transcription by RNA polymerase II ; transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	84458
	n/a
	ENSG00000196233
	n/a
	Q96JN0
	n/a
	NM_001170765 ; NM_001170766 ; NM_001346516 ; NM_015652 ; NM_032440 Contents Function ; References ; Further reading ; External links ;
	n/a
	NP_001164236 ; NP_001164237 ; NP_001333445 ; NP_115816
	n/a
	Wikidata
View/Edit Human

Last updated April 04, 2024

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.^[3]^[4]^[5]

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.^[5]

Related Research Articles

In molecular biology and genetics, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes. Transcription coregulators that activate gene transcription are referred to as coactivators while those that repress are known as corepressors. The mechanism of action of transcription coregulators is to modify chromatin structure and thereby make the associated DNA more or less accessible to transcription. In humans several dozen to several hundred coregulators are known, depending on the level of confidence with which the characterisation of a protein as a coregulator can be made. One class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP dependent class modifies the conformation of chromatin.

In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These intracellular receptors work with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism.

The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.

Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.

Retinoic acid receptor alpha (RAR-α), also known as NR1B1 is a nuclear receptor that in humans is encoded by the RARA gene.

<span class="mw-page-title-main">HDAC4</span>

Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene.

Nuclear receptor-interacting protein 1 (NRIP1) also known as receptor-interacting protein 140 (RIP140) is a protein that in humans is encoded by the NRIP1 gene.

Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene.

Neuromedin-U receptor 1 is a protein that in humans is encoded by the NMUR1 gene.

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.

Histone cluster 2, H3, pseudogene 2, also known as HIST2H3PS2, is a human gene.

K(lysine) acetyltransferase 6A (KAT6A), is an enzyme that, in humans, is encoded by the KAT6A gene. This gene is located on human chromosome 8, band 8p11.21.

Thyroid hormone receptor-associated protein 3 is a protein that in humans is encoded by the THRAP3 gene.

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.

Nuclear receptor coactivator 7 is a protein that in humans is encoded by the NCOA7 gene.

Nuclear receptor-binding factor 2 is a protein that in humans is encoded by the NRBF2 gene.

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.

THAP domain-containing protein 7 is a protein that in humans is encoded by the THAP7 gene.

HIRA-interacting protein 3 is a protein that in humans is encoded by the HIRIP3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196233 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell. 11 (1): 139–50. doi: 10.1016/S1097-2765(03)00014-5 . PMID 12535528.
↑ White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm. Vitamins & Hormones. 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. ISBN 978-0-12-709868-5. PMID 15193453.
1 2 "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor".

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196233 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12535528-3] Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell. 11 (1): 139–50. doi: 10.1016/S1097-2765(03)00014-5 . PMID 12535528.

[pmid15193453-4] White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm. Vitamins & Hormones. 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. ISBN 978-0-12-709868-5. PMID 15193453.

[entrez-5] 1 2 "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor".

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[2]

[3]

[4]

[5]

v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex SWI/SNF

LCOR

Contents

Function

Related Research Articles

References

Further reading

External links