SIN3B

SIN3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E91, 1PD7, 2CR7, 2CZY, 2F05
Identifiers
Aliases	SIN3B , Paired amphipathic helix protein Sin3b, SIN3 transcription regulator family member B
External IDs	OMIM: 607777; MGI: 107158; HomoloGene: 81810; GeneCards: SIN3B; OMA:SIN3B - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.11 Start 16,829,398 bp [1] End 16,880,353 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 B3.3|8 35.08 cM Start 73,449,913 bp [2] End 73,484,829 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus right uterine tube right ovary left ovary canal of the cervix right lung gastric mucosa left uterine tube left testis sural nerve Top expressed in Gonadal ridge Paneth cell internal carotid artery external carotid artery fossa renal corpuscle epithelium of lens condyle endocardial cushion medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity histone deacetylase activity chromatin binding protein binding Cellular component cytoplasm X chromosome Y chromosome autosome Sin3 complex nucleoplasm XY body nucleus chromatin Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of transcription, DNA-templated histone deacetylation regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23309 20467 Ensembl ENSG00000127511 ENSMUSG00000031622 UniProt O75182 Q62141 RefSeq (mRNA) NM_001297595 NM_001297597 NM_015260 NM_001113248 NM_009188 RefSeq (protein) NP_001284524 NP_001284526 NP_056075 NP_001106719 NP_033214 Location (UCSC) Chr 19: 16.83 – 16.88 Mb Chr 8: 73.45 – 73.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Paired amphipathic helix protein Sin3b is a protein that in human beings is encoded by the SIN3B gene. ^{[5] [6]}

Interactions

SIN3B has been shown to interact with HDAC1, ^{[7] [8]} Zinc finger and BTB domain-containing protein 16, ^[9] SUDS3 ^[10] and IKZF1. ^{[8] [11]}

See also

• Transcription coregulator

References

1. GRCh38: Ensembl release 89: ENSG00000127511 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031622 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" (PDF). DNA Research. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
6. "Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)".
7. Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC   316920 . PMID   10444591.
8. Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC   1171390 . PMID   10357820.
9. David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID   9627120. S2CID   655636.
10. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC   133736 . PMID   11909966.
11. Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–705. doi: 10.1074/jbc.M201694200 . PMID   12015313.

Further reading

• Ayer DE, Lawrence QA, Eisenman RN (Mar 1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3". Cell. 80 (5): 767–76. doi: 10.1016/0092-8674(95)90355-0 . PMID   7889570. S2CID   8749951.
• David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID   9627120. S2CID   655636.
• Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC   1171390 . PMID   10357820.
• Naruse Y, Aoki T, Kojima T, Mori N (Nov 1999). "Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13691–6. Bibcode:1999PNAS...9613691N. doi: 10.1073/pnas.96.24.13691 . PMC   24126 . PMID   10570134.
• Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW (Dec 2000). "The Mad1-Sin3B interaction involves a novel helical fold". Nature Structural Biology. 7 (12): 1100–4. doi:10.1038/81944. hdl: 2066/79474 . PMID   11101889. S2CID   12451972.
• Spronk CA, Jansen JF, Tessari M, Kaan AM, Aelen J, Lasonder E, Stunnenberg HG, Vuister GW (Apr 2001). "Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1". Journal of Biomolecular NMR. 19 (4): 377–8. doi:10.1023/A:1011262214741. hdl: 2066/79476 . PMID   11370785. S2CID   31789681.
• Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC   133736 . PMID   11909966.
• Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD (Apr 2002). "E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex". Genes & Development. 16 (8): 933–47. doi:10.1101/gad.969202. PMC   152357 . PMID   11959842.
• Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–705. doi: 10.1074/jbc.M201694200 . PMID   12015313.
• Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA (Feb 2003). "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". The Biochemical Journal. 369 (Pt 3): 651–7. doi:10.1042/BJ20020854. PMC   1223118 . PMID   12398767.
• Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A (May 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms". The Journal of Biological Chemistry. 278 (18): 16059–72. doi: 10.1074/jbc.M212935200 . PMID   12590135.
• Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC   196026 . PMID   12670868.
• Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N (Nov 2004). "Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential". Oncogene. 23 (55): 8887–99. doi:10.1038/sj.onc.1208107. PMID   15467743. S2CID   30045920.
• Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S (Oct 2005). "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex". Molecular and Cellular Biology. 25 (19): 8415–29. doi:10.1128/MCB.25.19.8415-8429.2005. PMC   1265755 . PMID   16166625.
• Xu Y, Sengupta PK, Seto E, Smith BD (Apr 2006). "Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression". The Journal of Biological Chemistry. 281 (14): 9260–70. doi: 10.1074/jbc.M511724200 . PMC   1434794 . PMID   16464847.

External links

• SIN3B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.