SUDS3

Last updated
SUDS3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SUDS3 , SAP45, SDS3, SDS3 homolog, SIN3A corepressor complex component
External IDs OMIM: 608250 MGI: 1919204 HomoloGene: 15906 GeneCards: SUDS3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022491

NM_001122666
NM_178622

RefSeq (protein)

NP_071936

NP_001116138
NP_848737

Location (UCSC) Chr 12: 118.38 – 118.42 Mb Chr 5: 117.09 – 117.12 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene. [5] [6]

Contents

Function

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM] [6]

Interactions

SUDS3 has been shown to interact with HDAC1, [5] [7] Host cell factor C1, [8] SIN3B [5] and SIN3A. [5] [7]

Related Research Articles

HDAC1

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

Histone deacetylase 2

Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. It belongs to the histone deacetylase class of enzymes responsible for the removal of acetyl groups from lysine residues at the N-terminal region of the core histones. As such, it plays an important role in gene expression by facilitating the formation of transcription repressor complexes and for this reason is often considered an important target for cancer therapy.

HDAC3

Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.

SIN3A

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.

RBBP4

Histone-binding protein RBBP4 is a protein that in humans is encoded by the RBBP4 gene.

HDAC6

Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene.

RBBP7

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

Host cell factor C1

Host cell factor 1, also known as VP16-accessory protein, is a protein that in humans is encoded by the HCFC1 gene.

Histone deacetylase 5

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.

HDAC9

Histone deacetylase 9 is an enzyme that in humans is encoded by the HDAC9 gene.

SAP30

Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene.

SIN3B

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.

MXD1

MAD protein is a protein that in humans is encoded by the MXD1 gene.

WDR5

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.

ARID4A

AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene.

SETD7

Histone-lysine N-methyltransferase SETD7 is an enzyme that in humans is encoded by the SETD7 gene.

ARID4B Protein

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.

SAP130

Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene.

ASH2L

Set1/Ash2 histone methyltransferase complex subunit ASH2 is an enzyme that in humans is encoded by the ASH2L gene.

SAP18

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000111707 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066900 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 4 Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (April 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC   133736 . PMID   11909966.
  6. 1 2 "Entrez Gene: SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)".
  7. 1 2 Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC   164750 . PMID   12724404.
  8. Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (April 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC   196026 . PMID   12670868.

Further reading