HMG20B

HMG20B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRJ
Identifiers
Aliases	HMG20B , BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857, high mobility group 20B
External IDs	OMIM: 605535; MGI: 1341190; HomoloGene: 74949; GeneCards: HMG20B; OMA:HMG20B - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 3,572,777 bp [1] End 3,579,088 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 81,181,882 bp [2] End 81,186,314 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium olfactory zone of nasal mucosa skin of leg muscle layer of sigmoid colon canal of the cervix popliteal artery tibial arteries skin of abdomen right uterine tube Top expressed in interventricular septum lip yolk sac genital tubercle granulocyte ventricular zone lens internal carotid artery tail of embryo duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity DNA binding protein binding histone deacetylase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm chromosome nuclear body Biological process skeletal muscle cell differentiation cell cycle negative regulation of protein sumoylation blood coagulation regulation of transcription, DNA-templated positive regulation of neuron differentiation transcription, DNA-templated histone deacetylation chromatin organization regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10362 15353 Ensembl ENSG00000064961 ENSMUSG00000020232 UniProt Q9P0W2 Q9Z104 RefSeq (mRNA) NM_006339 NM_001163165 NM_001163166 NM_010440 RefSeq (protein) NP_006330 NP_001156637 NP_001156638 NP_034570 Location (UCSC) Chr 19: 3.57 – 3.58 Mb Chr 10: 81.18 – 81.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene. ^{[5] [6]}

HMG20B is a high-mobility group (HMG) DNA binding protein. HMG20B contains a carboxy terminal region that is essential for cytokinesis since it regulates cell cycle progression from the G2 phase into mitosis ^[7] This carboxy terminal region of HMG20B interacts with the tumor suppressor protein BRCA2. A particular mutation in this region of the HMG20B gene is associated with lung cancer. This mutation interferes with the association of the HMG20B and BRCA2 proteins. ^[7]

Interactions

HMG20B has been shown to interact with:

• BRCA2, ^{[8] [9]}
• HDAC1, ^[8]
• HDAC2, ^{[8] [10]}
• KIF4A, ^[11]
• PHF21A, ^{[8] [12]} and
• RCOR1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000064961 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020232 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sumoy L, Carim L, Escarceller M, Nadal M, Gratacòs M, Pujana MA, Estivill X, Peral B (Jun 2000). "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression". Cytogenetics and Cell Genetics. 88 (1–2): 62–7. doi:10.1159/000015486. PMID   10773667. S2CID   22921110.
6. "Entrez Gene: HMG20B high-mobility group 20B".
7. Lee M, Venkitaraman AR (2014). "A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis". Cell Cycle. 13 (16): 2554–63. doi:10.4161/15384101.2014.942204. PMC   4614378 . PMID   25486196.
8. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi: 10.1073/pnas.112008599 . PMC   124246 . PMID   12032298.
9. Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R (January 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell. 104 (2): 247–57. doi: 10.1016/S0092-8674(01)00209-4 . PMID   11207365. S2CID   5822368.
10. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi: 10.1074/jbc.M208992200 . PMID   12493763.
11. Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC   1223617 . PMID   12809554.
12. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–8. Bibcode:2004BBRC..322..601I. doi:10.1016/j.bbrc.2004.07.163. PMID   15325272.

Further reading

• Wattler F, Wattler S, Kelly M, Skinner HB, Nehls M (September 1999). "Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family". Genomics. 60 (2): 172–8. doi:10.1006/geno.1999.5913. PMID   10486208.
• Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R (January 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell. 104 (2): 247–57. doi: 10.1016/S0092-8674(01)00209-4 . PMID   11207365. S2CID   5822368.
• Lee YM, Shin H, Choi W, Ahn S, Kim W (April 2002). "Characterization of human SMARCE1r high-mobility-group protein" . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1574 (3): 269–76. doi:10.1016/s0167-4781(01)00373-6. PMID   11997092.
• Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi: 10.1073/pnas.112008599 . PMC   124246 . PMID   12032298.
• Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (July 2002). "Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35". Biochemical and Biophysical Research Communications. 295 (1): 129–35. Bibcode:2002BBRC..295..129W. doi:10.1016/S0006-291X(02)00624-1. PMID   12083779.
• Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (July 2002). "Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens". Biochemical and Biophysical Research Communications. 295 (1): 136–41. Bibcode:2002BBRC..295..136W. doi:10.1016/S0006-291X(02)00625-3. PMID   12083780.
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi: 10.1074/jbc.M208992200 . PMID   12493763.
• Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC   1223617 . PMID   12809554.
• Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–8. Bibcode:2004BBRC..322..601I. doi:10.1016/j.bbrc.2004.07.163. PMID   15325272.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• HMG20B human gene location in the UCSC Genome Browser .
• HMG20B human gene details in the UCSC Genome Browser .