TUBA4A

TUBA4A
Identifiers
Aliases	TUBA4A , H2-ALPHA, TUBA1, ALS22, tubulin alpha 4a
External IDs	OMIM: 191110; MGI: 1095410; HomoloGene: 68496; GeneCards: TUBA4A; OMA:TUBA4A - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q35 Start 219,249,710 bp [1] End 219,277,902 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C4 Start 75,190,872 bp [2] End 75,196,509 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium frontal pole muscle of thigh Brodmann area 10 skin of arm body of tongue nipple spinal ganglia gastrocnemius muscle Skeletal muscle tissue of rectus abdominis Top expressed in motor neuron ankle right ventricle aortic valve triceps brachii muscle vastus lateralis muscle sternocleidomastoid muscle tibiofemoral joint temporal muscle hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding structural constituent of cytoskeleton protein binding GTPase activity enzyme binding protein kinase binding Cellular component cytoplasm cytosol extracellular region microtubule extracellular exosome cytoskeleton microtubule cytoskeleton Biological process platelet degranulation G2/M transition of mitotic cell cycle microtubule-based process cytoskeleton organization ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle microtubule cytoskeleton organization mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7277 22145 Ensembl ENSG00000127824 ENSMUSG00000026202 UniProt P68366 P68368 RefSeq (mRNA) NM_001278552 NM_006000 NM_009447 NM_001313723 NM_001313724 RefSeq (protein) NP_001265481 NP_005991 NP_001300652 NP_001300653 NP_033473 Location (UCSC) Chr 2: 219.25 – 219.28 Mb Chr 1: 75.19 – 75.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene. ^[5]

Function

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. ^[6]

Interactions

TUBA4A has been shown to interact with NCOA6 ^[7] and APC. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000127824 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026202 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Villasante A, Wang D, Dobner P, Dolph P, Lewis SA, Cowan NJ (Jul 1986). "Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes". Molecular and Cellular Biology. 6 (7): 2409–19. doi:10.1128/mcb.6.7.2409. PMC   367794 . PMID   3785200.
6. "Entrez Gene: TUBA4A tubulin, alpha 4a".
7. Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC   140670 . PMID   12482968.
8. Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS (Jan 2001). "Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation". Current Biology. 11 (1): 44–9. doi: 10.1016/S0960-9822(01)00002-1 . PMID   11166179. S2CID   15004529.

Further reading

• Desai A, Mitchison TJ (Jul 1998). "Tubulin and FtsZ structures: functional and therapeutic implications". BioEssays. 20 (7): 523–7. doi:10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L. PMID   9722999.
• Oakley BR (Dec 2000). "An abundance of tubulins". Trends in Cell Biology. 10 (12): 537–42. doi:10.1016/S0962-8924(00)01857-2. PMID   11121746.
• Dutcher SK (Feb 2001). "The tubulin fraternity: alpha to eta". Current Opinion in Cell Biology. 13 (1): 49–54. doi:10.1016/S0955-0674(00)00173-3. PMID   11163133.
• Kirsch J, Langosch D, Prior P, Littauer UZ, Schmitt B, Betz H (Nov 1991). "The 93-kDa glycine receptor-associated protein binds to tubulin". The Journal of Biological Chemistry. 266 (33): 22242–5. doi: 10.1016/S0021-9258(18)54560-9 . PMID   1657993.
• Dobner PR, Kislauskis E, Wentworth BM, Villa-Komaroff L (Jan 1987). "Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region". Nucleic Acids Research. 15 (1): 199–218. doi:10.1093/nar/15.1.199. PMC   340405 . PMID   3029670.
• Hall JL, Cowan NJ (Jan 1985). "Structural features and restricted expression of a human alpha-tubulin gene". Nucleic Acids Research. 13 (1): 207–23. doi:10.1093/nar/13.1.207. PMC   340985 . PMID   3839072.
• Alexandrova N, Niklinski J, Bliskovsky V, Otterson GA, Blake M, Kaye FJ, Zajac-Kaye M (Sep 1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro". Molecular and Cellular Biology. 15 (9): 5188–95. doi:10.1128/MCB.15.9.5188. PMC   230766 . PMID   7651436.
• Yamaguchi N, Fukuda MN (May 1995). "Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins". The Journal of Biological Chemistry. 270 (20): 12170–6. doi: 10.1074/jbc.270.33.19551 . PMID   7744867.
• Waterman-Storer CM, Karki S, Holzbaur EL (Feb 1995). "The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1634–8. Bibcode:1995PNAS...92.1634W. doi: 10.1073/pnas.92.5.1634 . PMC   42574 . PMID   7878030.
• Lu Q, Luduena RF (Jan 1994). "In vitro analysis of microtubule assembly of isotypically pure tubulin dimers. Intrinsic differences in the assembly properties of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers in the absence of microtubule-associated proteins". The Journal of Biological Chemistry. 269 (3): 2041–7. doi: 10.1016/S0021-9258(17)42132-6 . PMID   8294455.
• Paschal BM, Holzbaur EL, Pfister KK, Clark S, Meyer DI, Vallee RB (Jul 1993). "Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin". The Journal of Biological Chemistry. 268 (20): 15318–23. doi: 10.1016/S0021-9258(18)82472-3 . PMID   8325901.
• Huby RD, Carlile GW, Ley SC (Dec 1995). "Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells". The Journal of Biological Chemistry. 270 (51): 30241–4. doi: 10.1074/jbc.270.51.30241 . PMID   8530437.
• Marie-Cardine A, Kirchgessner H, Eckerskorn C, Meuer SC, Schraven B (Dec 1995). "Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase". European Journal of Immunology. 25 (12): 3290–7. doi:10.1002/eji.1830251214. PMID   8566014. S2CID   37614803.
• Peters JD, Furlong MT, Asai DJ, Harrison ML, Geahlen RL (Mar 1996). "Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine". The Journal of Biological Chemistry. 271 (9): 4755–62. doi: 10.1074/jbc.271.9.4755 . PMID   8617742.
• Best A, Ahmed S, Kozma R, Lim L (Feb 1996). "The Ras-related GTPase Rac1 binds tubulin". The Journal of Biological Chemistry. 271 (7): 3756–62. doi: 10.1074/jbc.271.7.3756 . PMID   8631991.
• Tokito MK, Howland DS, Lee VM, Holzbaur EL (Aug 1996). "Functionally distinct isoforms of dynactin are expressed in human neurons". Molecular Biology of the Cell. 7 (8): 1167–80. doi:10.1091/mbc.7.8.1167. PMC   275970 . PMID   8856662.
• Tian G, Lewis SA, Feierbach B, Stearns T, Rommelaere H, Ampe C, Cowan NJ (Aug 1997). "Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors". The Journal of Cell Biology. 138 (4): 821–32. doi:10.1083/jcb.138.4.821. PMC   2138046 . PMID   9265649.
• Vaillant AR, Müller R, Langkopf A, Brown DL (May 1998). "Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics". The Journal of Biological Chemistry. 273 (22): 13973–81. doi: 10.1074/jbc.273.22.13973 . PMID   9593747.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.