MAPRE2

MAPRE2
Identifiers
Aliases	MAPRE2 , EB1, EB2, RP1, CSCSC2, microtubule associated protein RP/EB family member 2
External IDs	OMIM: 605789; MGI: 106271; HomoloGene: 75027; GeneCards: MAPRE2; OMA:MAPRE2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q12.1-q12.2 Start 34,976,928 bp [1] End 35,143,470 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18 A2|18 12.08 cM Start 23,885,390 bp [2] End 24,026,918 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia corpus callosum inferior ganglion of vagus nerve C1 segment parietal lobe prefrontal cortex subthalamic nucleus postcentral gyrus entorhinal cortex pons Top expressed in Rostral migratory stream nucleus accumbens motor neuron ciliary body barrel cortex iris substantia nigra retinal pigment epithelium dorsal striatum external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding protein binding identical protein binding protein kinase binding microtubule plus-end binding Cellular component microtubule cytoskeleton microtubule plus-end microtubule cytoskeleton cytoplasm microtubule organizing center cytoplasmic microtubule focal adhesion spindle midzone Biological process cell cycle cell population proliferation signal transduction cell division regulation of microtubule polymerization or depolymerization positive regulation of ARF protein signal transduction protein localization to microtubule positive regulation of GTPase activity spindle assembly positive regulation of keratinocyte migration positive regulation of adherens junction organization protein localization to microtubule plus-end Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10982 212307 Ensembl ENSG00000166974 ENSMUSG00000024277 UniProt Q15555 Q8R001 RefSeq (mRNA) NM_001143826 NM_001143827 NM_001256420 NM_014268 NM_001162941 NM_001162942 NM_153058 RefSeq (protein) NP_001137298 NP_001137299 NP_001243349 NP_055083 NP_001156413 NP_001156414 NP_694698 Location (UCSC) Chr 18: 34.98 – 35.14 Mb Chr 18: 23.89 – 24.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. ^[7]

Interactions

MAPRE2 has been shown to interact with APC. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000166974 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024277 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. doi: 10.4049/jimmunol.159.3.1276 . PMID   9233623. S2CID   23797920.
6. Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ (Dec 2002). "EB1 targets to kinetochores with attached, polymerizing microtubules". Mol Biol Cell. 13 (12): 4308–16. doi:10.1091/mbc.E02-04-0236. PMC   138635 . PMID   12475954.
7. "Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2".
8. Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (Jul 1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID   7606712.
9. Nakamura M, Zhou XZ, Lu KP (Jul 2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. Bibcode:2001CBio...11.1062N. doi: 10.1016/S0960-9822(01)00297-4 . PMID   11470413. S2CID   14122895.

Further reading

• Tirnauer JS, Bierer BE (2000). "EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability". J. Cell Biol. 149 (4): 761–6. doi:10.1083/jcb.149.4.761. PMC   2174556 . PMID   10811817.
• Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID   7606712.
• Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE (1998). "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10596–601. Bibcode:1998PNAS...9510596B. doi: 10.1073/pnas.95.18.10596 . PMC   27940 . PMID   9724749.
• Morrison EE, Wardleworth BN, Askham JM, Markham AF, Meredith DM (1999). "EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle". Oncogene. 17 (26): 3471–7. doi:10.1038/sj.onc.1202247. PMID   10030671. S2CID   25818701.
• Juwana JP, Henderikx P, Mischo A, Wadle A, Fadle N, Gerlach K, Arends JW, Hoogenboom H, Pfreundschuh M, Renner C (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. doi: 10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z . PMID   10188731. S2CID   33232892.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Nakamura M, Zhou XZ, Lu KP (2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. Bibcode:2001CBio...11.1062N. doi: 10.1016/S0960-9822(01)00297-4 . PMID   11470413. S2CID   14122895.
• Askham JM, Vaughan KT, Goodson HV, Morrison EE (2003). "Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome". Mol. Biol. Cell. 13 (10): 3627–45. doi:10.1091/mbc.E02-01-0061. PMC   129971 . PMID   12388762.
• Bu W, Su LK (2004). "Characterization of functional domains of human EB1 family proteins". J. Biol. Chem. 278 (50): 49721–31. doi: 10.1074/jbc.M306194200 . PMID   14514668.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, Sasaki H, Matsui C, Severin F, Galjart N, Grosveld F, Vorobjev I, Tsukita S, Akhmanova A (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC   2171674 . PMID   15631994.
• Xu H, Hebert MD (2006). "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin". BMC Cell Biol. 6 (1): 23. doi: 10.1186/1471-2121-6-23 . PMC   1097723 . PMID   15862129.
• Wang Y, Zhou X, Zhu H, Liu S, Zhou C, Zhang G, Xue L, Lu N, Quan L, Bai J, Zhan Q, Xu N (2005). "Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway". Oncogene. 24 (44): 6637–45. doi:10.1038/sj.onc.1208819. PMID   16007168. S2CID   36511735.