Keratin 15

KRT15
Identifiers
Aliases	KRT15 , CK15, K15, K1CO, keratin 15
External IDs	OMIM: 148030; MGI: 96689; HomoloGene: 1712; GeneCards: KRT15; OMA:KRT15 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.2 Start 41,513,745 bp [1] End 41,522,529 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 63.41 cM Start 100,022,584 bp [2] End 100,026,754 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx skin of thigh skin of arm skin of abdomen epithelium of nasopharynx gums gingival epithelium cervix epithelium vulva skin of hip Top expressed in conjunctival fornix skin of abdomen lip esophagus transitional epithelium of urinary bladder skin of external ear cornea skin of back umbilical cord trachea More reference expression data BioGPS n/a
Gene ontology Molecular function scaffold protein binding structural constituent of cytoskeleton protein binding structural molecule activity Cellular component extracellular exosome intermediate filament nucleus cytosol Biological process epidermis development cytoskeleton organization keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3866 16665 Ensembl ENSG00000171346 ENSMUSG00000054146 UniProt P19012 Q61414 RefSeq (mRNA) NM_002275 NM_008469 RefSeq (protein) NP_002266 NP_032495 Location (UCSC) Chr 17: 41.51 – 41.52 Mb Chr 11: 100.02 – 100.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Keratin 15 is a protein that in humans is encoded by the KRT15 gene. ^{[5] [6]} It has also been referred to as cytokeratin 15, K1CO and KRTB.

Keratin 15 is a type I cytokeratin. It is well-expressed in the basal layer of complex epithelia. However, acral keratinocytes express little to no keratin 15. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171346 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054146 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Barletta C, Batticane N, Ragusa RM, Leube R, Peschle C, Romano V (1990). "Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization". Cytogenetics and Cell Genetics. 54 (3–4): 148–150. doi:10.1159/000132979. PMID   1702379.
6. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC   2064177 . PMID   16831889.
7. Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, et al. (August 2022). "Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes". JCI Insight. 7 (16) e159762. doi:10.1172/jci.insight.159762. PMC   9462509 . PMID   35900871.

Further reading

• Radoja N, Stojadinovic O, Waseem A, Tomic-Canic M, Milisavljevic V, Teebor S, Blumenberg M (April 2004). "Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription". Molecular and Cellular Biology. 24 (8): 3168–3179. doi:10.1128/MCB.24.8.3168-3179.2004. PMC   381600 . PMID   15060141.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Rittié L, Stoll SW, Kang S, Voorhees JJ, Fisher GJ (December 2009). "Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin". Aging Cell. 8 (6): 738–751. doi:10.1111/j.1474-9726.2009.00526.x. hdl: 2027.42/78718 . PMID   20050020. S2CID   8832389.
• Waseem A, Dogan B, Tidman N, Alam Y, Purkis P, Jackson S, et al. (March 1999). "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes". The Journal of Investigative Dermatology. 112 (3): 362–369. doi: 10.1046/j.1523-1747.1999.00535.x . PMID   10084315.
• Blumenberg M, Savtchenko ES (1986). "Linkage of human keratin genes". Cytogenetics and Cell Genetics. 42 (1–2): 65–71. doi:10.1159/000132253. PMID   2424675.
• Marchuk D, McCrohon S, Fuchs E (March 1985). "Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene". Proceedings of the National Academy of Sciences of the United States of America. 82 (6): 1609–1613. Bibcode:1985PNAS...82.1609M. doi: 10.1073/pnas.82.6.1609 . PMC   397321 . PMID   2580298.
• Bader BL, Jahn L, Franke WW (December 1988). "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene". European Journal of Cell Biology. 47 (2): 300–319. PMID   2468493.
• Choi CW, Park HS, Kim YK, Lee SH, Cho KH (August 2008). "Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma". The Journal of Dermatology. 35 (8): 499–502. doi: 10.1111/j.1346-8138.2008.00510.x . PMID   18789069. S2CID   36019385.
• Romano V, Bosco P, Rocchi M, Costa G, Leube RE, Franke WW, Romeo G (1988). "Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes". Cytogenetics and Cell Genetics. 48 (3): 148–151. doi:10.1159/000132612. PMID   2466616.
• Leube RE, Bader BL, Bosch FX, Zimbelmann R, Achtstaetter T, Franke WW (April 1988). "Molecular characterization and expression of the stratification-related cytokeratins 4 and 15". The Journal of Cell Biology. 106 (4): 1249–1261. doi:10.1083/jcb.106.4.1249. PMC   2114990 . PMID   2452170.
• Hanukoglu I, Fuchs E (November 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell. 31 (1): 243–252. doi:10.1016/0092-8674(82)90424-X. PMID   6186381. S2CID   35796315.
• Celis JE, Gromova I, Cabezón T, Gromov P, Shen T, Timmermans-Wielenga V, et al. (December 2007). "Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease". Molecular Oncology. 1 (3): 321–349. doi:10.1016/j.molonc.2007.09.004. PMC   5543867 . PMID   19383306.
• Werner S, Munz B (January 2000). "Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo". Experimental Cell Research. 254 (1): 80–90. doi:10.1006/excr.1999.4726. PMID   10623468.
• Whittock NV, Eady RA, McGrath JA (January 2000). "Genomic organization and amplification of the human keratin 15 and keratin 19 genes". Biochemical and Biophysical Research Communications. 267 (1): 462–465. doi:10.1006/bbrc.1999.1966. PMID   10623642.
• Al-Refu K, Goodfield M (May 2009). "Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus". Autoimmunity Reviews. 8 (6): 474–477. doi:10.1016/j.autrev.2008.12.015. PMID   19162247.