MYO1E

Last updated
MYO1E
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MYO1E , FSGS6, HuncM-IC, MYO1C, myosin IE
External IDs OMIM: 601479; MGI: 106621; HomoloGene: 55864; GeneCards: MYO1E; OMA:MYO1E - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004998

NM_181072
NM_025612

RefSeq (protein)

NP_004989

NP_851417

Location (UCSC) Chr 15: 59.13 – 59.37 Mb Chr 9: 70.11 – 70.31 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene. [5] [6]

Contents

Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain. [7]

The MYO1E gene was included in several genetic signatures for cancer prognosis. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000157483 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032220 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–439. doi: 10.1006/geno.1996.0488 . PMID   8884266.
  6. "Entrez Gene: MYO1E myosin IE".
  7. McConnell RE, Tyska MJ (July 2010). "Leveraging the membrane - cytoskeleton interface with myosin-1". Trends in Cell Biology. 20 (7): 418–426. doi:10.1016/j.tcb.2010.04.004. PMC   2897960 . PMID   20471271.
  8. Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi: 10.1186/s13040-022-00312-y . eISSN   1756-0381. PMC   9632055 . PMID   36329531.

Further reading