| MYH8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | MYH8 , MyHC-peri, MyHC-pn, gtMHC-F, DA7, myosin, heavy chain 8, skeletal muscle, perinatal, myosin heavy chain 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 160741 MGI: 1339712 HomoloGene: 68256 GeneCards: MYH8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Myosin-8 is a protein that in humans is encoded by the MYH8 gene. [5] [6]
Mutations in MYH8 are associated with Trismus pseudocamptodactyly syndrome.
The MYH16 gene encodes a protein called myosin heavy chain 16, which is a muscle protein in mammals. At least in primates, it is a specialized muscle protein found only in the temporalis and masseter muscles of the jaw. Myosin heavy chain proteins are important in muscle contraction, and if they are missing, the muscles will be smaller. In non-human primates, MYH16 is functional and the animals have powerful jaw muscles. In humans, the MYH16 gene has a mutation that causes the protein not to function. Although the exact importance of this change in accounting for differences between humans and other apes is not yet clear, such a change may be related to increased brain size and finer control of the jaw, which facilitates speech. It is not clear how the MYH16 mutation relates to other changes to the jaw and skull in early human evolution.
MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform expressed primarily in the heart, but also in skeletal muscles. This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β is the major protein comprising the thick filament in cardiac muscle and plays a major role in cardiac muscle contraction.
Myosin regulatory light polypeptide 9 is a protein that in humans is encoded by the MYL9 gene.
Myosin-9 also known as myosin, heavy chain 9, non-muscle or non-muscle myosin heavy chain IIa (NMMHC-IIA) is a protein which in humans is encoded by the MYH9 gene.
Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene.
Collagen alpha-2(VI) chain is a protein that in humans is encoded by the COL6A2 gene.
Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene.
Myosin-11 is a protein that in humans is encoded by the MYH11 gene.
Myosin heavy chain, α isoform (MHC-α) is a protein that in humans is encoded by the MYH6 gene. This isoform is distinct from the ventricular/slow myosin heavy chain isoform, MYH7, referred to as MHC-β. MHC-α isoform is expressed predominantly in human cardiac atria, exhibiting only minor expression in human cardiac ventricles. It is the major protein comprising the cardiac muscle thick filament, and functions in cardiac muscle contraction. Mutations in MYH6 have been associated with late-onset hypertrophic cardiomyopathy, atrial septal defects and sick sinus syndrome.
Myosin-binding protein C, slow-type is a protein that in humans is encoded by the MYBPC1 gene.
Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene. This cardiac ventricular/slow skeletal ELC isoform is distinct from that expressed in fast skeletal muscle (MYL1) and cardiac atrial muscle (MYL4). Ventricular ELC is part of the myosin molecule and is important in modulating cardiac muscle contraction.
Myosin-2 is a protein that in humans is encoded by the MYH2 gene.
Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene. This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail.
Myosin-14 is a protein that in humans is encoded by the MYH14 gene.
Myosin-3 is a protein that in humans is encoded by the MYH3 gene.
Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.
Myosin-15 also known as myosin, heavy chain 15 is a protein that in humans is encoded by the MYH15 gene.
Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene.
Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene.
Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.
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