KIF19

KIF19
Identifiers
Aliases	KIF19 , KIF19A, kinesin family member 19
External IDs	MGI: 2447024 HomoloGene: 17709 GeneCards: KIF19
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,355,820 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	114,681,565 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; spleen; ; hypothalamus; ; amygdala; ; caudate nucleus; ; putamen; ; bronchial epithelial cell; ; Brodmann area 9; ; substantia nigra;
	Top expressed in
	islet of Langerhans; ; spermatocyte; ; hypothalamus; ; testicle; ; mirror; ; ovary; ; spermatid; ; morula; ; quadriceps femoris muscle; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding ; microtubule motor activity ; nucleotide binding ; ATPase activity ; plus-end-directed microtubule motor activity ; ATP binding ;
Cellular component	cytoplasm ; axoneme ; cell projection ; cilium ; microtubule ; cytoskeleton ; kinesin complex ;
Biological process	microtubule-based movement ; axonemal microtubule depolymerization ; plus-end specific microtubule depolymerization ;
	Sources:Amigo / QuickGO
Orthologs
	124602
	286942
	ENSG00000196169
	ENSMUSG00000010021
	Q2TAC6
	Q99PT9
	NM_153209
	NM_001102615
	NP_694941
	NP_001096085
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 17, 2022

Kinesin family member 19 (KIF19) is a protein in humans encoded by the KIF19 gene. It is part of the kinesin family of motor proteins.

Function

KIF19 is involved in cancer metastasis, as well as cell-cell and cell-matrix interactions.^[5]

Related Research Articles

Kinesin family member 5B (KIF5B) is a protein that in humans is encoded by the KIF5B gene.

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

Kinesin-like protein KIF20A is a protein that in humans is encoded by the KIF20A gene.

Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.

Kinesin-like protein KIF13A is a protein that in humans is encoded by the KIF13A gene.

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene. KIF17 and its close relative, C. elegans OSM-3, are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins. In contrast to heterotrimeric kinesin-2 motors, however, KIF17 and OSM-3 form distinct homodimeric complexes. Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane, whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.

KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene. The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.

Kinesin-like protein KIF3C is a protein that in humans is encoded by the KIF3C gene.

Kinesin family member 16B, also known as KIF16B, is a protein which in humans is encoded by the KIF16B gene.

Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene.

Kinesin family member 6 is a protein that in humans is encoded by the KIF6 gene. This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport.

Kinesin family member 13B is a protein that in humans is encoded by the KIF13B gene.

KIF4B is a human protein encoded by the gene KIF4B. It is part of the kinesin family of proteins, which are motor proteins involved in many cellular processes.

Kinesin family member 7 (KIF7), also known as kinesin-4, is a human protein encoded by the gene KIF7. It is part of the kinesin family of motor proteins.

Kinesin family member 9 (KIF9), also known as kinesin-9, is a human protein encoded by the KIF9 gene. It is part of the kinesin family of motor proteins.

Kinesin family member 12 (KIF12), also known as kinesin-12, is a human protein encoded by the gene KIF12. It is part of the kinesin family of motor proteins.

Kinesin family member 25 (KIF25), also known as kinesin-14, is a human protein encoded by the KIF25 gene. It is part of the kinesin family of motor proteins.

Kinesin family member 27 (KIF27), also known as kinesin-4, is a human protein encoded by the KIF27 gene. It is part of the kinesin family of motor proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196169 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010021 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Eisenberg, Samuel C.; Dey, Abhinav; Birnbaum, Rayna; Sharp, David J. (2020-09-04). "The kinesin-8 member Kif19 alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion". doi:10.1101/2020.09.04.282657. S2CID 221589215.{{cite journal}}: Cite journal requires |journal= (help)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196169 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010021 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Eisenberg, Samuel C.; Dey, Abhinav; Birnbaum, Rayna; Sharp, David J. (2020-09-04). "The kinesin-8 member Kif19 alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion". doi:10.1101/2020.09.04.282657. S2CID 221589215.{{cite journal}}: Cite journal requires |journal= (help)

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