DYNLL2

DYNLL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XQQ, 3P8M, 4D07, 1PWJ
Identifiers
Aliases	DYNLL2 , DNCL1B, Dlc2, RSPH22, dynein light chain LC8-type 2
External IDs	OMIM: 608942; MGI: 1915347; HomoloGene: 115597; GeneCards: DYNLL2; OMA:DYNLL2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q22 Start 58,083,419 bp [1] End 58,095,542 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 C Start 87,870,351 bp [2] End 87,878,359 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus myocardium of left ventricle sperm cardiac muscle tissue of right atrium skin of arm mucosa of ileum pons superior vestibular nucleus pars compacta ventral tegmental area Top expressed in motor neuron mammillary body lateral hypothalamus lateral geniculate nucleus seminiferous tubule ventromedial nucleus medial vestibular nucleus dorsomedial hypothalamic nucleus cingulate gyrus lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal motor activity protein binding plus-end-directed microtubule motor activity dynein intermediate chain binding dynein light intermediate chain binding cytoskeletal protein binding protein homodimerization activity protein heterodimerization activity scaffold protein binding Cellular component cytoplasm cytosol nucleus membrane ciliary tip centrosome microtubule plasma membrane microtubule associated complex dynein complex cytoskeleton mitochondrion cilium myosin V complex cytoplasmic dynein complex myosin complex postsynaptic density postsynapse glutamatergic synapse Biological process microtubule-based process antigen processing and presentation of exogenous peptide antigen via MHC class II endoplasmic reticulum to Golgi vesicle-mediated transport positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway macroautophagy intraciliary transport involved in cilium assembly transport along microtubule cilium assembly sister chromatid cohesion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140735 68097 Ensembl ENSG00000264364 ENSMUSG00000020483 UniProt Q96FJ2 Q9D0M5 RefSeq (mRNA) NM_080677 NM_001168471 NM_001168472 NM_026556 RefSeq (protein) NP_542408 NP_001161943 NP_001161944 NP_080832 Location (UCSC) Chr 17: 58.08 – 58.1 Mb Chr 11: 87.87 – 87.88 Mb PubMed search [3] [4]
Wikidata
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Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene. ^{[5] [6]}

Interactions

DYNLL2 has been shown to interact with DLG4, ^[7] C12orf40, ^[8] DLGAP1, ^[7] MYO5A ^{[7] [9]} and BMF. ^{[9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000264364 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020483 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, et al. (November 2005). "Cytoplasmic dynein nomenclature". The Journal of Cell Biology. 171 (3): 411–413. doi:10.1083/jcb.200508078. PMC   2171247 . PMID   16260502.
6. "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".
7. Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, et al. (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". The Journal of Neuroscience. 20 (12): 4524–4534. doi: 10.1523/JNEUROSCI.20-12-04524.2000 . PMC   6772433 . PMID   10844022.
8. Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC   4266588 . PMID   25416956.
9. Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, et al. (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536): 1829–1832. Bibcode:2001Sci...293.1829P. doi:10.1126/science.1062257. PMID   11546872. S2CID   5638023.
10. Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, et al. (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". The Biochemical Journal. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC   1223895 . PMID   14561217.

Further reading

• Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, et al. (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". The Journal of Neuroscience. 20 (12): 4524–4534. doi: 10.1523/JNEUROSCI.20-12-04524.2000 . PMC   6772433 . PMID   10844022.
• Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T (November 2000). "The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase". Genes to Cells. 5 (11): 905–911. doi: 10.1046/j.1365-2443.2000.00374.x . PMID   11122378. S2CID   37107139.
• Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, et al. (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536): 1829–1832. Bibcode:2001Sci...293.1829P. doi:10.1126/science.1062257. PMID   11546872. S2CID   5638023.
• Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, et al. (July 2002). "Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes". The Journal of Neuroscience. 22 (13): 5393–5402. doi: 10.1523/JNEUROSCI.22-13-05393.2002 . PMC   6758200 . PMID   12097491.
• Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, et al. (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". The Biochemical Journal. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC   1223895 . PMID   14561217.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Donner J, Pirkola S, Silander K, Kananen L, Terwilliger JD, Lönnqvist J, et al. (October 2008). "An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders". Biological Psychiatry. 64 (8): 672–680. doi:10.1016/j.biopsych.2008.06.002. PMC   2682432 . PMID   18639233.

External links

• Overview of all the structural information available in the PDB for UniProt : Q96FJ2 (Dynein light chain 2, cytoplasmic) at the PDBe-KB .