DYNLL2

DYNLL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XQQ, 3P8M, 4D07, 1PWJ
Identifiers
Aliases	DYNLL2 , DNCL1B, Dlc2, RSPH22, dynein light chain LC8-type 2
External IDs	OMIM: 608942 MGI: 1915347 HomoloGene: 115597 GeneCards: DYNLL2
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q22 Start 58,083,419 bp [1] End 58,095,542 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 C Start 87,870,351 bp [2] End 87,878,359 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus sperm pons superior vestibular nucleus ventral tegmental area external globus pallidus parietal lobe postcentral gyrus subthalamic nucleus superior frontal gyrus Top expressed in motor neuron mammillary body lateral hypothalamus lateral geniculate nucleus seminiferous tubule ventromedial nucleus medial vestibular nucleus dorsomedial hypothalamic nucleus cingulate gyrus cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal motor activity protein binding plus-end-directed microtubule motor activity dynein intermediate chain binding dynein light intermediate chain binding cytoskeletal protein binding protein homodimerization activity protein heterodimerization activity scaffold protein binding Cellular component cytoplasm cytosol nucleus membrane ciliary tip centrosome microtubule plasma membrane microtubule associated complex dynein complex cytoskeleton mitochondrion cilium myosin V complex cytoplasmic dynein complex myosin complex postsynaptic density postsynapse glutamatergic synapse Biological process microtubule-based process antigen processing and presentation of exogenous peptide antigen via MHC class II endoplasmic reticulum to Golgi vesicle-mediated transport positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway macroautophagy intraciliary transport involved in cilium assembly transport along microtubule cilium assembly sister chromatid cohesion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140735 68097 Ensembl ENSG00000264364 ENSMUSG00000020483 UniProt Q96FJ2 Q9D0M5 RefSeq (mRNA) NM_080677 NM_001168471 NM_001168472 NM_026556 RefSeq (protein) NP_542408 NP_001161943 NP_001161944 NP_080832 Location (UCSC) Chr 17: 58.08 – 58.1 Mb Chr 11: 87.87 – 87.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene. ^{[5] [6]}

Interactions

DYNLL2 has been shown to interact with DLG4, ^[7] C12orf40, ^[8] DLGAP1, ^[7] MYO5A ^{[7] [9]} and BMF. ^{[9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000264364 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020483 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (November 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC   2171247 . PMID   16260502.
6. "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".
7. Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; Weinberg R J; Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. UNITED STATES. 20 (12): 4524–34. doi: 10.1523/JNEUROSCI.20-12-04524.2000 . ISSN   0270-6474. PMC   6772433 . PMID   10844022.
8. Rolland, Thomas; Taşan, Murat; Charloteaux, Benoit; Pevzner, Samuel J.; Zhong, Quan; Sahni, Nidhi; Yi, Song; Lemmens, Irma; Fontanillo, Celia; Mosca, Roberto; Kamburov, Atanas; Ghiassian, Susan D.; Yang, Xinping; Ghamsari, Lila; Balcha, Dawit; Begg, Bridget E.; Braun, Pascal; Brehme, Marc; Broly, Martin P.; Carvunis, Anne-Ruxandra; Convery-Zupan, Dan; Corominas, Roser; Coulombe-Huntington, Jasmin; Dann, Elizabeth; Dreze, Matija; Dricot, Amélie; Fan, Changyu; Franzosa, Eric; Gebreab, Fana; Gutierrez, Bryan J.; Hardy, Madeleine F.; Jin, Mike; Kang, Shuli; Kiros, Ruth; Lin, Guan Ning; Luck, Katja; MacWilliams, Andrew; Menche, Jörg; Murray, Ryan R.; Palagi, Alexandre; Poulin, Matthew M.; Rambout, Xavier; Rasla, John; Reichert, Patrick; Romero, Viviana; Ruyssinck, Elien; Sahalie, Julie M.; Scholz, Annemarie; Shah, Akash A.; Sharma, Amitabh; Shen, Yun; Spirohn, Kerstin; Tam, Stanley; Tejeda, Alexander O.; Trigg, Shelly A.; Twizere, Jean-Claude; Vega, Kerwin; Walsh, Jennifer; Cusick, Michael E.; Xia, Yu; Barabási, Albert-László; Iakoucheva, Lilia M.; Aloy, Patrick; De Las Rivas, Javier; Tavernier, Jan; Calderwood, Michael A.; Hill, David E.; Hao, Tong; Roth, Frederick P.; Vidal, Marc (November 2014). "A Proteome-Scale Map of the Human Interactome Network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC   4266588 . PMID   25416956.
9. Puthalakath, H; Villunger A; O'Reilly L A; Beaumont J G; Coultas L; Cheney R E; Huang D C; Strasser A (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science . United States. 293 (5536): 1829–32. Bibcode:2001Sci...293.1829P. doi:10.1126/science.1062257. ISSN   0036-8075. PMID   11546872. S2CID   5638023.
10. Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. England. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC   1223895 . PMID   14561217.

Further reading

• Naisbitt S, Valtschanoff J, Allison DW, et al. (2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. 20 (12): 4524–34. doi: 10.1523/JNEUROSCI.20-12-04524.2000 . PMC   6772433 . PMID   10844022.
• Haraguchi K, Satoh K, Yanai H, et al. (2001). "The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase". Genes Cells. 5 (11): 905–911. doi: 10.1046/j.1365-2443.2000.00374.x . PMID   11122378. S2CID   37107139.
• Puthalakath H, Villunger A, O'Reilly LA, et al. (2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536): 1829–32. Bibcode:2001Sci...293.1829P. doi:10.1126/science.1062257. PMID   11546872. S2CID   5638023.
• Fuhrmann JC, Kins S, Rostaing P, et al. (2002). "Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes". J. Neurosci. 22 (13): 5393–402. doi: 10.1523/JNEUROSCI.22-13-05393.2002 . PMC   6758200 . PMID   12097491.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Day CL, Puthalakath H, Skea G, et al. (2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC   1223895 . PMID   14561217.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Overview of all the structural information available in the PDB for UniProt : Q96FJ2 (Dynein light chain 2, cytoplasmic) at the PDBe-KB .

• Donner J, et al. (2008). "An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders". Biological Psychiatry. 64 (8): 672–680. doi:10.1016/j.biopsych.2008.06.002. PMC   2682432 . PMID   18639233.