Centromere protein J is a protein that in humans is encoded by the CENPJ gene. It is also known as centrosomal P4.1-associated protein (CPAP). During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein.
Pericentrin (kendrin), also known as PCNT and pericentrin-B (PCNTB), is a protein which in humans is encoded by the PCNT gene on chromosome 21. This protein localizes to the centrosome and recruits proteins to the pericentriolar matrix (PCM) to ensure proper centrosome and mitotic spindle formation, and thus, uninterrupted cell cycle progression. This gene is implicated in many diseases and disorders, including congenital disorders such as microcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel syndrome.
Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.
Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.
Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.
Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.
WD repeat-containing protein 62 is a protein that in humans is encoded by the WDR62 gene.
Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.
Centrin-1 is a protein that in humans is encoded by the CETN1 gene. It belongs to the centrin family of proteins.
Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.
Centrobin is a protein that in humans is encoded by the CNTROB gene. It is a centriole-associated protein that asymmetrically localizes to the daughter centriole, and is required for centriole duplication and cytokinesis.
Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.
Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.
Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. Its function appears two be twofold: CEP164 is required for primary cilium formation. Furthermore, it is an important component in the response to DNA damage by UV light.
Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.
Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene. It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.
Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene. This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.
Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.
Tubulin, delta 1 is a protein in humans that is encoded by the TUBD1 gene.
Sfi1 homolog, spindle assembly associated (yeast) is a protein that in humans is encoded by the SFI1 gene. It localizes to the centriole, and its S. pombe ortholog has been shown to be involved in spindle pole body duplication. SFI1 forms a complex with centrin 2.
