Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene. [5]
Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene. [5]
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 23 subunits (11 individual proteins ranging in size from 22 to 150 kD). [6] Dynactin binds to cytoplasmic dynein, dynein cargo adaptors, and microtubules. [7] It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
This subunit is commonly referred to p150-glued. [5] It is present in two copies per dynactin complex and forms an ≈75 nm long flexible arm that extends from the main body of dynactin. [6] The p150-glued arm contains binding sites for microtubules, [8] the microtubule plus tip binding protein EB1, [9] and the N-terminus of the dynein intermediate chain. [10] [11]
Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy. [12]
DCTN1 has been shown to interact with:
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