KIF2A

KIF2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GRY
Identifiers
Aliases	KIF2A , CDCBM3, HK2, KIF2, kinesin heavy chain member 2A, kinesin family member 2A
External IDs	OMIM: 602591; MGI: 108390; HomoloGene: 3320; GeneCards: KIF2A; OMA:KIF2A - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q12.1 Start 62,306,162 bp [1] End 62,391,025 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 D2.1 Start 107,095,504 bp [2] End 107,158,634 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum ganglionic eminence monocyte sperm ventricular zone external globus pallidus sural nerve subthalamic nucleus pars compacta superior vestibular nucleus Top expressed in barrel cortex blood genital tubercle habenula tail of embryo zygote secondary oocyte olfactory bulb facial motor nucleus spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule motor activity nucleotide binding microtubule binding ATPase activity protein binding cytoskeletal motor activity ATP binding Cellular component cytoplasm cytosol centrosome spindle pole membrane kinesin complex spindle microtubule organizing center sperm principal piece spindle microtubule nucleolus microtubule cytoskeleton nucleus nuclear body centriole centriolar subdistal appendage Biological process cell differentiation antigen processing and presentation of exogenous peptide antigen via MHC class II mitotic spindle organization nervous system development cell division multicellular organism development microtubule-based movement mitotic spindle assembly cell cycle retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum sister chromatid cohesion microtubule cytoskeleton organization microtubule depolymerization regulation of cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3796 16563 Ensembl ENSG00000068796 ENSMUSG00000021693 UniProt O00139 P28740 RefSeq (mRNA) NM_004520 NM_001098511 NM_001243952 NM_001243953 NM_001145779 NM_008442 NM_001374727 NM_001378936 NM_001378937 NM_001378938 NM_001378939 NM_001378940 RefSeq (protein) NP_001091981 NP_001230881 NP_001230882 NP_004511 NP_001139251 NP_032468 NP_001361656 NP_001365865 NP_001365866 NP_001365867 NP_001365868 NP_001365869 Location (UCSC) Chr 5: 62.31 – 62.39 Mb Chr 13: 107.1 – 107.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene. ^{[5] [6]} In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons. ^[7]

Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000068796 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021693 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D (May 1997). "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique". Genomics. 42 (1): 67–73. doi:10.1006/geno.1997.4720. PMID   9177777.
6. "Entrez Gene: KIF2A kinesin heavy chain member 2A".
7. Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, et al. (November 2022). "KIF2A deficiency causes early-onset neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America. 119 (46) e2209714119. Bibcode:2022PNAS..11909714R. doi: 10.1073/pnas.2209714119 . PMC   9674219 . PMID   36343267.

Further reading

• Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA (August 2007). "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells". Molecular Biology of the Cell. 18 (8): 2970–2979. doi:10.1091/mbc.E07-02-0110. PMC   1949365 . PMID   17538014.
• Schepis A, Stauber T, Krijnse Locker J (August 2007). "Kinesin-1 plays multiple roles during the vaccinia virus life cycle". Cellular Microbiology. 9 (8): 1960–1973. doi: 10.1111/j.1462-5822.2007.00927.x . PMID   17394562. S2CID   23205204.
• Li C, Zheng Y, Qin W, Tao R, Pan Y, Xu Y, et al. (October 2006). "A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia". Neuroscience Letters. 407 (2): 151–155. doi:10.1016/j.neulet.2006.08.025. PMID   16959419. S2CID   32742823.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Ganem NJ, Upton K, Compton DA (October 2005). "Efficient mitosis in human cells lacking poleward microtubule flux". Current Biology. 15 (20): 1827–1832. Bibcode:2005CBio...15.1827G. doi: 10.1016/j.cub.2005.08.065 . PMID   16243029. S2CID   8541946.
• Ganem NJ, Compton DA (August 2004). "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK". The Journal of Cell Biology. 166 (4): 473–478. doi:10.1083/jcb.200404012. PMC   2172212 . PMID   15302853.
• Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, et al. (December 2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–2144. Bibcode:2003Sci...302.2141J. CiteSeerX   10.1.1.1017.9438 . doi:10.1126/science.1090100. PMID   14684825. S2CID   10007258.

External links

• Overview of all the structural information available in the PDB for UniProt : O00139 (Human Kinesin-like protein KIF2A) at the PDBe-KB .