KIF22

KIF22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EDU, 3BFN
Identifiers
Aliases	KIF22 , A-328A3.2, KID, KNSL4, OBP, OBP-1, OBP-2, SEMDJL2, kinesin family member 22
External IDs	OMIM: 603213 MGI: 109233 HomoloGene: 32011 GeneCards: KIF22
Gene location (Human)
Chr.	Chromosome 16 (human)
End	29,805,385 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,641,643 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; rectum; ; right lobe of liver; ; skin of abdomen; ; anterior pituitary; ; left ventricle; ; spleen; ; right uterine tube;
	Top expressed in
	Paneth cell; ; medial ganglionic eminence; ; primitive streak; ; ureter; ; internal carotid artery; ; fossa; ; external carotid artery; ; condyle; ; maxillary prominence; ; renal corpuscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding ; nucleotide binding ; microtubule binding ; ATPase activity ; protein binding ; ATP binding ; microtubule motor activity ;
Cellular component	kinesin complex ; spindle ; Chromatin ; mitotic spindle ; microtubule ; cytoskeleton ; kinetochore ; nucleus ; cytoplasm ; cytosol ; nuclear speck ;
Biological process	metaphase plate congression ; antigen processing and presentation of exogenous peptide antigen via MHC class II ; sister chromatid cohesion ; microtubule-based movement ; mitotic metaphase plate congression ; DNA repair ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ; mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	3835
	110033
	ENSG00000079616
	ENSMUSG00000030677
	Q14807
	Q3V300
	NM_001256269 ; NM_001256270 ; NM_007317
	NM_145588
	NP_001243198 ; NP_001243199 ; NP_015556
	NP_663563 ; NP_001390552
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance.^[7]

Interactions

KIF22 has been shown to interact with SIAH1.^[8]

Clinical relevance

Mutations in this gene have been shown to cause developmental disorders such as Spondyloepimetaphyseal dysplasia with joint laxity.^[9]

Related Research Articles

Kinesin-like protein KIF23 is a protein that in humans is encoded by the KIF23 gene.

Kinesin-like protein KIF1B is a protein that in humans is encoded by the KIF1B gene.

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.

Chromosome-associated kinesin KIF4A is a protein that in humans is encoded by the KIF4A gene.

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene.

Kinesin-like protein KIF20A is a protein that in humans is encoded by the KIF20A gene.

Kinesin-like protein KIF21A is a protein that in humans is encoded by the KIF21A gene.

Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene.

Kinesin-associated protein 3 (KAP3) is a protein that in humans is encoded by the KIFAP3 gene. It is a non-motor, accessory subunit which co-oligomerizes with the motor subunits KIF3A and KIF3B or KIF3C, to form heterotrimeric kinesin-2 motor proteins. Kinesin-2 KAP subunits were initially characterized in echinoderms and mice.

Kinesin-like protein KIF18A is a protein that in humans is encoded by the KIF18A gene.

Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.

Kinesin-like protein KIF13A is a protein that in humans is encoded by the KIF13A gene.

KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene. The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.

Kinesin-like protein KIF3C is a protein that in humans is encoded by the KIF3C gene.

Kinesin family member 16B, also known as KIF16B, is a protein which in humans is encoded by the KIF16B gene.

Kinesin-like protein KIF11 is a molecular motor protein that is essential in mitosis. In humans it is coded for by the gene KIF11. Kinesin-like protein KIF11 is a member of the kinesin superfamily, which are nanomotors that move along microtubule tracks in the cell. Named from studies in the early days of discovery, it is also known as Kinesin-5, or as BimC, Eg5 or N-2, based on the founding members of this kinesin family.

Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000079616 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030677 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T (April 1996). "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle". EMBO J. 15 (3): 457–67. doi:10.1002/j.1460-2075.1996.tb00378.x. PMC 449964 . PMID 8599929.
↑ Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc Natl Acad Sci U S A. 98 (13): 7004–11. Bibcode:2001PNAS...98.7004M. doi: 10.1073/pnas.111145398 . PMC 34614 . PMID 11416179.
1 2 "Entrez Gene: KIF22 kinesin family member 22".
↑ Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi: 10.1038/sj.onc.1204002 . PMID 11146551.
↑ Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ (December 2011). "Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type". Am. J. Hum. Genet. 89 (6): 760–6. doi:10.1016/j.ajhg.2011.10.015. PMC 3234366 . PMID 22152677.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Zhang S, Nonoyama M (1994). "The cellular proteins that bind specifically to the Epstein-Barr virus origin of plasmid DNA replication belong to a gene family". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2843–7. Bibcode:1994PNAS...91.2843Z. doi: 10.1073/pnas.91.7.2843 . PMC 43467 . PMID 8146198.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Song J, Murakami H, Tsutsui H, et al. (1998). "Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ)". J. Biol. Chem. 273 (32): 20603–14. doi: 10.1074/jbc.273.32.20603 . PMID 9685418.
Song J, Murakami H, Yang ZQ, et al. (1998). "Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2". Genomics. 52 (3): 374–7. doi:10.1006/geno.1998.5452. PMID 9790757.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Funabiki H, Murray AW (2000). "The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement". Cell. 102 (4): 411–24. doi: 10.1016/S0092-8674(00)00047-7 . PMID 10966104. S2CID 3010084.
Antonio C, Ferby I, Wilhelm H, et al. (2000). "Xkid, a chromokinesin required for chromosome alignment on the metaphase plate". Cell. 102 (4): 425–35. doi: 10.1016/S0092-8674(00)00048-9 . PMID 10966105. S2CID 17113314.
Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi: 10.1038/sj.onc.1204002 . PMID 11146551.
Levesque AA, Compton DA (2001). "The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles". J. Cell Biol. 154 (6): 1135–46. doi:10.1083/jcb.200106093. PMC 2150818 . PMID 11564754.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Yajima J, Edamatsu M, Watai-Nishii J, et al. (2003). "The human chromokinesin Kid is a plus end-directed microtubule-based motor". EMBO J. 22 (5): 1067–74. doi:10.1093/emboj/cdg102. PMC 150335 . PMID 12606572.
Shiroguchi K, Ohsugi M, Edamatsu M, et al. (2003). "The second microtubule-binding site of monomeric kid enhances the microtubule affinity". J. Biol. Chem. 278 (25): 22460–5. doi: 10.1074/jbc.M212274200 . PMID 12692123.
Ohsugi M, Tokai-Nishizumi N, Shiroguchi K, et al. (2003). "Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes". EMBO J. 22 (9): 2091–103. doi:10.1093/emboj/cdg208. PMC 156080 . PMID 12727876.
Venkatesh LK, Gettemeier T, Chinnadurai G (2003). "A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein". J. Virol. 77 (13): 7236–43. doi:10.1128/JVI.77.13.7236-7243.2003. PMC 164832 . PMID 12805422.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Tokai-Nishizumi N, Ohsugi M, Suzuki E, Yamamoto T (2006). "The chromokinesin Kid is required for maintenance of proper metaphase spindle size". Mol. Biol. Cell. 16 (11): 5455–63. doi:10.1091/mbc.E05-03-0244. PMC 1266440 . PMID 16176979.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000079616 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030677 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8599929-5] Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T (April 1996). "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle". EMBO J. 15 (3): 457–67. doi:10.1002/j.1460-2075.1996.tb00378.x. PMC 449964 . PMID 8599929.

[pmid11416179-6] Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc Natl Acad Sci U S A. 98 (13): 7004–11. Bibcode:2001PNAS...98.7004M. doi: 10.1073/pnas.111145398 . PMC 34614 . PMID 11416179.

[entrez-7] 1 2 "Entrez Gene: KIF22 kinesin family member 22".

[pmid11146551-8] Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi: 10.1038/sj.onc.1204002 . PMID 11146551.

[pmid22152677-9] Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ (December 2011). "Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type". Am. J. Hum. Genet. 89 (6): 760–6. doi:10.1016/j.ajhg.2011.10.015. PMC 3234366 . PMID 22152677.

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KIF22

Contents

Interactions

Clinical relevance

Related Research Articles

References

Further reading