KRT37

KRT37
Identifiers
Aliases	KRT37 , HA7, K37, KRTHA7, keratin 37
External IDs	OMIM: 604541; HomoloGene: 122145; GeneCards: KRT37; OMA:KRT37 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,424,585 bp
RNA expression pattern
	Top expressed in
	gonad; ; skin of abdomen; ; skin of leg; ; canal of the cervix; ; ectocervix; ; smooth muscle tissue; ; vagina; ; wall of uterus; ; endometrium; ; right lung;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity ;
Cellular component	intermediate filament ; extracellular exosome ; cytosol ;
Biological process	keratinization ; cornification ;
	Sources:Amigo / QuickGO
Orthologs
	8688
	n/a
	ENSG00000263022 ; ENSG00000108417
	n/a
	O76014
	n/a
	NM_003770
	n/a
	NP_003761
	n/a
	Wikidata
View/Edit Human

Last updated August 15, 2024

Keratin, type I cuticular Ha7 is a protein that in humans is encoded by the KRT37 gene. KRT37 is a member of the keratin gene family. The protein is a type I keratin and a hair keratin.

Clinical significance

KRT37 is the only keratin that is regulated by androgens.^[3] This sensitivity to androgens was acquired by Homo sapiens and is not shared with their great ape cousins. Although Winter et al. found that KRT37 is expressed in all the hair follicles of chimpanzees, it was not detected in the head hair of modern humans. As androgens are known to grow hair on the body but decrease it on the scalp, this lack of scalp KRT37 may help explain the paradoxical nature of androgenic alopecia as well as the fact that head hair anagen cycles are extremely long. Moreover, variations in the gene may account for ethnic differences in body and facial hair.

Related Research Articles

Keratin 6A is one of the 27 different type II keratins expressed in humans. Keratin 6A was the first type II keratin sequence determined. Analysis of the sequence of this keratin together with that of the first type I keratin led to the discovery of the four helical domains in the central rod of keratins. In humans Keratin 6A is encoded by the KRT6A gene.

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.

Keratin 15 is a protein that in humans is encoded by the KRT15 gene. It has also been referred to as cytokeratin 15, K1CO and KRTB.

Hair keratin is a type of keratin found in hair and the nails.

Pattern hair loss is a hair loss condition that primarily affects the top and front of the scalp. In male-pattern hair loss (MPHL), the hair loss typically presents itself as either a receding front hairline, loss of hair on the crown and vertex of the scalp, or a combination of both. Female-pattern hair loss (FPHL) typically presents as a diffuse thinning of the hair across the entire scalp.

Keratin 6C, is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. This gene was uncovered recently by the Human Genome Project and its expression patterns in humans remains unknown.

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.

Keratin, type I cuticular Ha1 is a protein that in humans is encoded by the KRT31 gene.

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.

Keratin, type I cuticular Ha3-II is a protein that in humans is encoded by the KRT33B gene.

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.

Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.

Keratin 83, also known as KRT83, is a protein which humans is encoded by the KRT83 gene.

KRT71 is a keratin gene. Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.

KRT38 is a keratin gene. Its corresponding protein is asymmetrically distributed within human hair follicles. It does not have murine or equine orthologs. The encoded protein is a type I keratin and a hair keratin.

References

1 2 3 ENSG00000108417 GRCh38: Ensembl release 89: ENSG00000263022, ENSG00000108417 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jave-Suarez LF, Langbein L, Winter H, Praetzel S, Rogers MA, Schweizer J (March 2004). "Androgen regulation of the human hair follicle: the type I hair keratin hHa7 is a direct target gene in trichocytes". The Journal of Investigative Dermatology. 122 (3): 555–64. doi: 10.1111/j.0022-202X.2004.22336.x . PMID 15086535.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000108417 GRCh38: Ensembl release 89: ENSG00000263022, ENSG00000108417 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15086535-3] Jave-Suarez LF, Langbein L, Winter H, Praetzel S, Rogers MA, Schweizer J (March 2004). "Androgen regulation of the human hair follicle: the type I hair keratin hHa7 is a direct target gene in trichocytes". The Journal of Investigative Dermatology. 122 (3): 555–64. doi: 10.1111/j.0022-202X.2004.22336.x . PMID 15086535.

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