Keratin 34

KRT34
Identifiers
Aliases	KRT34 , HA4, Ha-4, KRTHA4, hHa4, Keratin 34, K34
External IDs	OMIM: 602763; MGI: 1309994; HomoloGene: 31083; GeneCards: KRT34; OMA:KRT34 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.2 Start 41,377,669 bp [1] End 41,382,306 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 63.38 cM Start 99,928,173 bp [2] End 99,932,380 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle stromal cell of endometrium placenta skin of abdomen ectocervix skin of leg vagina canal of the cervix right lung mucosa of esophagus Top expressed in lip skin of back hair follicle skin of abdomen dermis skin of external ear sexually immature organism conjunctival fornix medial head of gastrocnemius muscle foregut More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity Cellular component intermediate filament extracellular exosome extracellular space cytosol Biological process epidermis development keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3885 16672 Ensembl ENSG00000131737 ENSG00000262045 ENSMUSG00000043485 UniProt O76011 Q9D646 RefSeq (mRNA) NM_021013 NM_001386014 NM_027563 RefSeq (protein) NP_066293 NP_081839 Location (UCSC) Chr 17: 41.38 – 41.38 Mb Chr 11: 99.93 – 99.93 Mb PubMed search [3] [4]
Wikidata
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Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene. ^{[5] [6] [7] [8]}

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription. ^[8]

See also

• 34βE12 (keratin 903)

References

1. ENSG00000262045 GRCh38: Ensembl release 89: ENSG00000131737, ENSG00000262045 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043485 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation. 32 (2): 101–19. doi:10.1111/j.1432-0436.1986.tb00562.x. PMID   2431943.
6. Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi: 10.1074/jbc.273.41.26683 . PMID   9756910.
7. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC   2064177 . PMID   16831889.
8. "Entrez Gene: KRT34 keratin 34".

Further reading

• Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635 (inactive 2024-04-03). PMID   7686952.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Raica M, Zylis D, Cîmpean AM (2007). "Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma". Romanian Journal of Morphology and Embryology. 46 (1): 11–5. PMID   16286979.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi: 10.1074/jbc.274.28.19874 . PMID   10391933.