KRT36

KRT36
Identifiers
Aliases	KRT36 , HA6, KRTHA6, hHa6, keratin 36
External IDs	OMIM: 604540 MGI: 109364 HomoloGene: 88459 GeneCards: KRT36
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,492,546 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,996,452 bp
RNA expression pattern
	Top expressed in
	body of tongue; ; superior surface of tongue; ; spleen; ; cervix; ; lymph node; ; skin of limb; ; vagina; ; skin of abdomen; ; gallbladder; ; appendix;
	Top expressed in
	lip; ; hair follicle; ; skin of back; ; tongue; ; filiform papilla; ; skin of abdomen; ; mammary gland; ; oocyte; ; tracheobronchial tree; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity ; structural constituent of skin epidermis ;
Cellular component	intermediate filament cytoskeleton ; extracellular exosome ; intermediate filament ; cytosol ;
Biological process	regulation of keratinocyte differentiation ; keratinization ; cornification ; biological process ;
	Sources:Amigo / QuickGO
Orthologs
	8689
	16673
	ENSG00000126337
	ENSMUSG00000020916
	O76013
	B1AQ75
	NM_003771
	NM_001174099 ; NM_008472
	NP_003762
	NP_001167570
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 04, 2024

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.^[7]

Related Research Articles

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene. Keratin 10 is a type I keratin.

Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin 19 is a type I keratin.

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.

Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18.

Envoplakin is a protein that in humans is encoded by the EVPL gene.

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.

Keratin, type I cuticular Ha1 is a protein that in humans is encoded by the KRT31 gene.

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.

Keratin, type I cuticular Ha3-II is a protein that in humans is encoded by the KRT33B gene.

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.

Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.

Keratin 83, also known as KRT83, is a protein which humans is encoded by the KRT83 gene.

Keratin 80, also known as KRT80, is a protein which humans is encoded by the KRT80 gene.

Mitogen-activated protein kinase 12, also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000126337 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020916 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi: 10.1074/jbc.273.41.26683 . PMID 9756910.
↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177 . PMID 16831889.
1 2 "Entrez Gene: KRT36 keratin 36".

Fuchs E, Weber K (1994). "Intermediate filaments: structure, dynamics, function, and disease". Annu. Rev. Biochem. 63: 345–82. doi:10.1146/annurev.bi.63.070194.002021. PMID 7979242.
Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635 (inactive 2024-04-03). PMID 7686952.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi: 10.1074/jbc.274.28.19874 . PMID 10391933.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000126337 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020916 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9756910-5] Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi: 10.1074/jbc.273.41.26683 . PMID 9756910.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177 . PMID 16831889.

[entrez-7] 1 2 "Entrez Gene: KRT36 keratin 36".

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KRT36

Related Research Articles

References

Further reading