DYNC1I2

DYNC1I2
Identifiers
Aliases	DYNC1I2 , DNCI2, IC2, DIC74, dynein cytoplasmic 1 intermediate chain 2, NEDMIBA
External IDs	OMIM: 603331; MGI: 107750; HomoloGene: 133934; GeneCards: DYNC1I2; OMA:DYNC1I2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q31.1 Start 171,687,409 bp [1] End 171,750,158 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 C2|2 42.38 cM Start 71,042,050 bp [2] End 71,093,647 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence C1 segment ventricular zone sural nerve smooth muscle tissue islet of Langerhans popliteal artery tibial arteries Descending thoracic aorta Top expressed in genital tubercle ganglionic eminence spermatocyte barrel cortex medial ganglionic eminence fossa superior cervical ganglion condyle median eminence zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule motor activity protein binding cytoskeletal motor activity plus-end-directed microtubule motor activity dynein light chain binding dynein heavy chain binding Cellular component vesicle cytosol centrosome dynein complex cytoskeleton cytoplasm microtubule cytoplasmic dynein complex Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II endoplasmic reticulum to Golgi vesicle-mediated transport G2/M transition of mitotic cell cycle viral process microtubule-based movement ciliary basal body-plasma membrane docking transport along microtubule regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1781 13427 Ensembl ENSG00000077380 ENSMUSG00000027012 UniProt Q13409 O88487 RefSeq (mRNA) NM_001271785 NM_001271786 NM_001271787 NM_001271788 NM_001271789 NM_001271790 NM_001378 NM_001320882 NM_001320883 NM_001320884 NM_001378455 NM_001378456 NM_001198872 NM_001198873 NM_001198874 NM_001198875 NM_001198876 NM_001198877 NM_001198878 NM_010064 NM_001347173 RefSeq (protein) NP_001258714 NP_001258715 NP_001258716 NP_001258717 NP_001258718 NP_001258719 NP_001307811 NP_001307812 NP_001307813 NP_001369 NP_001365384 NP_001365385 NP_001185801 NP_001185802 NP_001185803 NP_001185804 NP_001185805 NP_001185806 NP_001185807 NP_001334102 NP_034194 Location (UCSC) Chr 2: 171.69 – 171.75 Mb Chr 2: 71.04 – 71.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cytoplasmic dynein 1 intermediate chain 2 is a protein that in humans is encoded by the DYNC1I2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000077380 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027012 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID   10049579.
6. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC   2171247 . PMID   16260502.
7. "Entrez Gene: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Vaughan KT, Vallee RB (1996). "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued". J. Cell Biol. 131 (6 Pt 1): 1507–16. doi:10.1083/jcb.131.6.1507. PMC   2120689 . PMID   8522607.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Davies TH, Ning YM, Sánchez ER (2002). "A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins". J. Biol. Chem. 277 (7): 4597–600. doi: 10.1074/jbc.C100531200 . PMID   11751894.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLOS Biol. 2 (7): E207. doi: 10.1371/journal.pbio.0020207 . PMC   449870 . PMID   15252450.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.