MYO1G

MYO1G
Identifiers
Aliases	MYO1G , HA2, HLA-HA2, MHAG, myosin IG
External IDs	OMIM: 600642; MGI: 1927091; HomoloGene: 27996; GeneCards: MYO1G; OMA:MYO1G - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p13 Start 44,962,662 bp [1] End 44,979,088 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A1 Start 6,456,548 bp [2] End 6,470,965 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte thymus blood lymph node cecum appendix spleen pylorus bone marrow cells Top expressed in granulocyte lymph node mesenteric lymph nodes spleen tibiofemoral joint thymus bone marrow blood stroma of bone marrow subcutaneous adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding calmodulin binding phosphatidylinositol-3,4-bisphosphate binding actin binding phosphatidylinositol-4,5-bisphosphate binding cytoskeletal motor activity ATP binding phosphatidylinositol-3,4,5-trisphosphate binding lipid binding Cellular component cell projection membrane filopodium plasma membrane microvillus phagocytic cup extracellular exosome leading edge membrane myosin complex lamellipodium Biological process T cell migration T cell mediated immunity adaptive immune response Fc-gamma receptor signaling pathway involved in phagocytosis cell gliding immune system process cell-substrate adhesion phagocytosis exocytosis T cell meandering migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64005 246177 Ensembl ENSG00000136286 ENSMUSG00000020437 UniProt B0I1T2 Q5SUA5 RefSeq (mRNA) NM_033054 NM_178440 RefSeq (protein) NP_149043 NP_848534 Location (UCSC) Chr 7: 44.96 – 44.98 Mb Chr 11: 6.46 – 6.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene. ^[5] MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain. ^[6] MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.

Function

MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010].

References

1. GRCh38: Ensembl release 89: ENSG00000136286 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020437 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Myosin IG" . Retrieved 24 December 2019.
6. Olety B, Wälte M, Honnert U, Schillers H, Bähler M (February 2010). "Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity". FEBS Letters. 584 (3): 493–9. Bibcode:2010FEBSL.584..493O. doi: 10.1016/j.febslet.2009.11.096 . PMID   19968988. S2CID   27557093.,

Further reading

• Patino-Lopez G, Aravind L, Dong X, Kruhlak MJ, Ostap EM, Shaw S (March 2010). "Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH)". J. Biol. Chem. 285 (12): 8675–86. doi: 10.1074/jbc.M109.086959 . PMC   2838290 . PMID   20071333.
• Larsen ME, Kornblit B, Larsen MV, Masmas TN, Nielsen M, Thiim M, Garred P, Stryhn A, Lund O, Buus S, Vindelov L (October 2010). "Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation". Biol. Blood Marrow Transplant. 16 (10): 1370–81. doi:10.1016/j.bbmt.2010.03.022. PMID   20353833.
• Lio HY, Tang JL, Wu J, Wu SJ, Lin CY, Yang YC (September 2010). "Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in Taiwan: frequency and application in hematopoietic stem cell transplantation". Clin. Chem. Lab. Med. 48 (9): 1287–93. doi:10.1515/CCLM.2010.246. PMID   20509834. S2CID   32914575.
• Sellami MH, Torjemane L, Espadas de Arias A, Kaabi H, Ladeb S, Ben Othman T, Poli F, Hmida S (2010). "Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs". Immunol. Invest. 39 (6): 611–20. doi:10.3109/08820131003775029. PMID   20653428. S2CID   38774267.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.