MYO9B

MYO9B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5C5S, 5HPY
Identifiers
Aliases	MYO9B , CELIAC4, MYR5, myosin IXB
External IDs	OMIM: 602129; MGI: 106624; HomoloGene: 3058; GeneCards: MYO9B; OMA:MYO9B - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.11 Start 17,075,777 bp [1] End 17,214,537 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 B3.3|8 34.43 cM Start 71,725,358 bp [2] End 71,813,357 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte sural nerve left testis C1 segment right testis spleen right hemisphere of cerebellum ascending aorta Descending thoracic aorta upper lobe of left lung Top expressed in ascending aorta granulocyte gastrula tunica media of zone of aorta internal carotid artery stroma of bone marrow external carotid artery aortic valve calvaria neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein homodimerization activity metal ion binding calmodulin binding microfilament motor activity protein binding actin binding cytoskeletal motor activity ATP binding Roundabout binding ADP binding GTPase activator activity ATPase activity Cellular component cytoplasm membrane cell cortex actin cytoskeleton perinuclear region of cytoplasm cytoskeleton myosin complex actin filament cytosol Biological process intracellular signal transduction ARF protein signal transduction Roundabout signaling pathway actin filament-based movement positive regulation of GTPase activity regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction signal transduction Rho protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4650 17925 Ensembl ENSG00000099331 ENSMUSG00000004677 UniProt Q13459 Q9QY06 RefSeq (mRNA) NM_001130065 NM_004145 NM_001142322 NM_001142323 NM_015742 RefSeq (protein) NP_001123537 NP_004136 n/a Location (UCSC) Chr 19: 17.08 – 17.21 Mb Chr 8: 71.73 – 71.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MYO9B is a gene that encodes the Myosin-IXb protein. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000099331 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004677 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bahler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (Sep 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics. 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID   9226381.
6. "Entrez Gene: MYO9B myosin IXB".

Further reading

• Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi: 10.1073/pnas.91.14.6549 . PMC   44240 . PMID   8022818.
• Wirth JA, Jensen KA, Post PL, et al. (1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail". J. Cell Sci. 109 (3): 653–61. doi:10.1242/jcs.109.3.653. PMID   8907710.
• Post PL, Bokoch GM, Mooseker MS (1998). "Human myosin-IXb is a mechanochemically active motor and a GAP for rho". J. Cell Sci. 111 (7): 941–50. doi:10.1242/jcs.111.7.941. PMID   9490638.
• Grewal PK, Jones AM, Maconochie M, et al. (2000). "Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing". Gene. 240 (2): 389–98. doi:10.1016/S0378-1119(99)00459-X. PMID   10580159.
• Post PL, Tyska MJ, O'Connell CB, et al. (2002). "Myosin-IXb is a single-headed and processive motor". J. Biol. Chem. 277 (14): 11679–83. doi: 10.1074/jbc.M111173200 . PMID   11801597.
• Inoue A, Saito J, Ikebe R, Ikebe M (2002). "Myosin IXb is a single-headed minus-end-directed processive motor". Nat. Cell Biol. 4 (4): 302–6. doi:10.1038/ncb774. PMID   11901422. S2CID   12158370.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Van Belzen MJ, Meijer JW, Sandkuijl LA, et al. (2003). "A major non-HLA locus in celiac disease maps to chromosome 19". Gastroenterology. 125 (4): 1032–41. doi: 10.1016/S0016-5085(03)01205-8 . PMID   14517787.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity". J. Biol. Chem. 280 (11): 10128–34. doi: 10.1074/jbc.M413415200 . PMID   15644318.
• Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID   15790807. S2CID   13047538.
• Monsuur AJ, de Bakker PI, Alizadeh BZ, et al. (2006). "Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect". Nat. Genet. 37 (12): 1341–4. doi:10.1038/ng1680. PMID   16282976. S2CID   35506194.
• Kambara T, Ikebe M (2006). "A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX". J. Biol. Chem. 281 (8): 4949–57. doi: 10.1074/jbc.M509141200 . PMID   16338935.
• Nishikawa M, Nishikawa S, Inoue A, et al. (2006). "A unique mechanism for the processive movement of single-headed myosin-IX". Biochem. Biophys. Res. Commun. 343 (4): 1159–64. doi:10.1016/j.bbrc.2006.03.057. PMID   16616011.
• Amundsen SS, Monsuur AJ, Wapenaar MC, et al. (2006). "Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort". Hum. Immunol. 67 (4–5): 341–5. doi:10.1016/j.humimm.2006.03.020. PMID   16720215.
• Giordano M, Marano C, Mellai M, et al. (2007). "A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population". Genes Immun. 7 (7): 606–8. doi: 10.1038/sj.gene.6364331 . PMID   16943798.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• van Bodegraven AA, Curley CR, Hunt KA, et al. (2007). "Genetic variation in myosin IXB is associated with ulcerative colitis". Gastroenterology. 131 (6): 1768–74. doi:10.1053/j.gastro.2006.09.011. PMID   17087940.
• Núñez C, Márquez A, Varadé J, et al. (2007). "No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population". Tissue Antigens. 68 (6): 489–92. doi:10.1111/j.1399-0039.2006.00699.x. PMID   17176439.

External links

• Overview of all the structural information available in the PDB for UniProt : Q13459 (Human Unconventional myosin-IXb (MYO9B)) at the PDBe-KB .