MYO1F

MYO1F
Identifiers
Aliases	MYO1F , myosin IF
External IDs	OMIM: 601480; MGI: 107711; HomoloGene: 56276; GeneCards: MYO1F; OMA:MYO1F - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 8,520,778 bp [1] End 8,577,577 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 B1|17 17.98 cM Start 33,774,681 bp [2] End 33,826,738 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen bone marrow cells right lung appendix upper lobe of left lung sural nerve trabecular bone Top expressed in granulocyte stroma of bone marrow blood spleen mesenteric lymph nodes lumbar spinal ganglion calvaria thymus subcutaneous adipose tissue right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding actin binding cytoskeletal motor activity ATP binding calmodulin binding microtubule motor activity microtubule binding Cellular component unconventional myosin complex myosin complex Biological process biological process microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4542 17916 Ensembl ENSG00000142347 ENSMUSG00000024300 UniProt O00160 P70248 RefSeq (mRNA) NM_012335 NM_001348355 NM_053214 RefSeq (protein) NP_036467 NP_001335284 n/a Location (UCSC) Chr 19: 8.52 – 8.58 Mb Chr 17: 33.77 – 33.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin-If is a protein that in humans is encoded by the MYO1F gene. ^{[5] [6] [7]}

It is expressed mainly in the immune system and might be involved in cell adhesion and motility. ^[8] It is a candidate gene for (among other things) nonsyndromic deafness. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000142347 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024300 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID   9119401.
6. Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi: 10.1006/geno.1996.0488 . PMID   8884266.
7. "Entrez Gene: MYO1F myosin IF".
8. Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA (October 2006). "Modulation of cell adhesion and motility in the immune system by Myo1f". Science. 314 (5796): 136–9. Bibcode:2006Sci...314..136K. doi:10.1126/science.1131920. PMID   17023661. S2CID   12479761.
9. Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ (August 2001). "MYO1F as a candidate gene for nonsyndromic deafness, DFNB15". Arch. Otolaryngol. Head Neck Surg. 127 (8): 921–5. doi: 10.1001/archotol.127.8.921 . PMID   11493199.

Further reading

• Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi: 10.1073/pnas.91.14.6549 . PMC   44240 . PMID   8022818.
• Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell. 9 (1): 95–108. doi: 10.1016/S1097-2765(02)00434-3 . PMID   11804589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.