DYNLRB1

Last updated

DYNLRB1
Protein DYNLRB1 PDB 1y4o.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DYNLRB1 , BITH, BLP, DNCL2A, DNLC2A, ROBLD1, dynein light chain roadblock-type 1
External IDs OMIM: 607167; MGI: 1914318; HomoloGene: 69161; GeneCards: DYNLRB1; OMA:DYNLRB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291108
NM_025947

RefSeq (protein)

NP_001306086
NP_054902
NP_001369294
NP_001369295
NP_001369296

Contents

NP_001278037
NP_080223

Location (UCSC) Chr 20: 34.52 – 34.54 Mb Chr 2: 155.08 – 155.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene. [5] [6] [7]

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125971 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047459 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients". Gene. 281 (1–2): 103–13. doi:10.1016/S0378-1119(01)00787-9. PMID   11750132.
  6. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC   2171247 . PMID   16260502.
  7. 1 2 "Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1".

Further reading