DYNLRB1

DYNLRB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z09, 2B95, 2E8J, 2HZ5
Identifiers
Aliases	DYNLRB1 , BITH, BLP, DNCL2A, DNLC2A, ROBLD1, dynein light chain roadblock-type 1
External IDs	OMIM: 607167 MGI: 1914318 HomoloGene: 69161 GeneCards: DYNLRB1
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.22 Start 34,516,409 bp [1] End 34,540,958 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 155,078,453 bp [2] End 155,092,197 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 9 tibial nerve islet of Langerhans left coronary artery popliteal artery thoracic aorta anterior pituitary ascending aorta right uterine tube right coronary artery Top expressed in supraoptic nucleus seminal vesicula yolk sac ascending aorta aortic valve ganglionic eminence dorsal tegmental nucleus right lung lobe lateral hypothalamus medial vestibular nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding microtubule motor activity cytoskeletal motor activity dynein intermediate chain binding Cellular component centrosome ciliary tip cytoskeleton membrane cytoplasm microtubule cilium cytoplasmic dynein complex dynein complex outer dynein arm Biological process visual behavior microtubule-based movement intraciliary transport involved in cilium assembly transport response to light stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83658 67068 Ensembl ENSG00000125971 ENSMUSG00000047459 UniProt Q9NP97 P62627 RefSeq (mRNA) NM_001281727 NM_001281728 NM_001281729 NM_014183 NM_177953 NM_001319157 NM_001291108 NM_025947 RefSeq (protein) NP_001306086 NP_054902 NP_001369294 NP_001369295 NP_001369296 NP_001278037 NP_080223 Location (UCSC) Chr 20: 34.52 – 34.54 Mb Chr 2: 155.08 – 155.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene. ^{[5] [6] [7]}

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000125971 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047459 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients". Gene. 281 (1–2): 103–13. doi:10.1016/S0378-1119(01)00787-9. PMID   11750132.
6. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC   2171247 . PMID   16260502.
7. "Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1".

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Susalka SJ, Nikulina K, Salata MW, et al. (2002). "The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain". J. Biol. Chem. 277 (36): 32939–46. doi: 10.1074/jbc.M205510200 . PMID   12077152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMC   196011 . PMID   12629046.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Saito Y, Doi K, Yamagishi N, et al. (2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID   14733918.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Campbell IG, Phillips WA, Choong DY (2006). "Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers". Clin. Cancer Res. 12 (12): 3713–5. doi:10.1158/1078-0432.CCR-06-0800. PMID   16778097.
• Pérez-González A, Rodriguez A, Huarte M, et al. (2007). "hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator". J. Mol. Biol. 362 (5): 887–900. doi:10.1016/j.jmb.2006.07.085. PMID   16950395.
• Liu JF, Wang ZX, Wang XQ, et al. (2006). "Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74". Biochem. Biophys. Res. Commun. 349 (3): 1125–9. doi:10.1016/j.bbrc.2006.08.161. PMID   16970917.
• Kang HC, Kim IJ, Kim K, et al. (2007). "km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers". Cancer Genet. Cytogenet. 175 (2): 173–4. doi:10.1016/j.cancergencyto.2007.02.004. PMID   17556076.
• Wanschers B, van de Vorstenbosch R, Fransen J, et al. (2008). "Rab6 family proteins interact with the dynein light chain protein DYNLRB1". Cell Motil. Cytoskeleton. 65 (3): 183–96. doi:10.1002/cm.20254. PMID   18044744.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9NP97 (Dynein light chain roadblock-type 1) at the PDBe-KB .