DYNLT1

DYNLT1
Identifiers
Aliases	DYNLT1 , CW-1, TCTEL1, tctex-1, dynein light chain Tctex-type 1, TCTEX1
External IDs	OMIM: 601554 MGI: 98643 HomoloGene: 4754 GeneCards: DYNLT1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	158,644,743 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	6,703,695 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; palpebral conjunctiva; ; cavity of mouth; ; ganglionic eminence; ; islet of Langerhans; ; jejunal mucosa; ; monocyte; ; parotid gland; ; right uterine tube; ; smooth muscle tissue;
	Top expressed in
	spermatid; ; spermatocyte; ; neural tube; ; mesencephalon; ; lens; ; testicle; ; islet of Langerhans; ; urinary bladder; ; uterus; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; identical protein binding ; cytoskeletal motor activity ; protein C-terminus binding ;
Cellular component	cytoplasm ; Golgi apparatus ; secretory vesicle ; spindle ; dynein complex ; cytoplasmic microtubule ; microtubule ; cytoskeleton ; host cell ; extracellular region ; cytoplasmic dynein complex ; secretory granule lumen ; ficolin-1-rich granule lumen ; mitochondrion ; lamellipodium ; neuronal cell body ; axonal growth cone ;
Biological process	intracellular transport of viral protein in host cell ; regulation of G protein-coupled receptor signaling pathway ; negative regulation of neurogenesis ; nervous system development ; cell division ; establishment of mitotic spindle orientation ; microtubule-dependent intracellular transport of viral material towards nucleus ; viral entry into host cell ; cell cycle ; viral process ; transport of viral material towards nucleus ; neutrophil degranulation ; positive regulation of neuron projection development ; dendrite development ; positive regulation of Rac protein signal transduction ; negative regulation of mitochondrial membrane permeability ; regulation of GTPase activity ; neuron projection morphogenesis ; regulation of cytoskeleton organization ; negative regulation of cell death ; axon development ;
	Sources:Amigo / QuickGO
Orthologs
	6993
	21648
	ENSG00000146425
	ENSMUSG00000096255
	P63172
	P51807
	NM_006519 ; NM_001291602 ; NM_001291603
	NM_009342
	NP_001278531 ; NP_001278532 ; NP_006510
	NP_001160099 ; NP_001186877 ; NP_001160102 ; NP_001160101 ; NP_033368
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 29, 2023

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.^[5]^[6]^[7]

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146425 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000096255 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (Jul 1996). "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q". Cytogenet Cell Genet. 73 (1–2): 153–6. doi:10.1159/000134329. PMID 8646886.
↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247 . PMID 16260502.
1 2 "Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1".

Tete R, de Montgolfier R, Piante M (1971). "[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]". Journal de Médecine de Lyon. 52 (192): 1523–6 passim. PMID 5503857.
King SM, Dillman JF, Benashski SE, et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein". J. Biol. Chem. 271 (50): 32281–7. doi: 10.1074/jbc.271.50.32281 . PMID 8943288.
Nagano F, Orita S, Sasaki T, et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi: 10.1074/jbc.273.46.30065 . PMID 9804756.
Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription". J. Biol. Chem. 275 (4): 2399–403. doi: 10.1074/jbc.275.4.2399 . PMID 10644691.
Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis". J. Biol. Chem. 277 (10): 7897–904. doi: 10.1074/jbc.M111937200 . PMID 11751937.
Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. PMID 12009301. S2CID 11632830.
Nadano D, Nakayama J, Matsuzawa S, et al. (2002). "Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton". Biochem. J. 364 (Pt 3): 669–77. doi:10.1042/BJ20011836. PMC 1222615 . PMID 12049630.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Machado RD, Rudarakanchana N, Atkinson C, et al. (2004). "Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension". Hum. Mol. Genet. 12 (24): 3277–86. doi: 10.1093/hmg/ddg365 . PMID 14583445.
Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi: 10.1074/jbc.M311671200 . PMID 15117959.
Ohka S, Matsuda N, Tohyama K, et al. (2004). "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome". J. Virol. 78 (13): 7186–98. doi:10.1128/JVI.78.13.7186-7198.2004. PMC 421661 . PMID 15194795.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
de Wit NJ, Verschuure P, Kappé G, et al. (2005). "Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1". Eur. J. Cell Biol. 83 (7): 337–45. doi:10.1078/0171-9335-00396. PMID 15503857.
Chuang JZ, Yeh TY, Bollati F, et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth". Dev. Cell. 9 (1): 75–86. doi:10.1016/j.devcel.2005.04.003. PMC 3857739 . PMID 15992542.
Yeh TY, Peretti D, Chuang JZ, et al. (2007). "Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin". Traffic. 7 (11): 1495–502. doi:10.1111/j.1600-0854.2006.00482.x. PMC 3873093 . PMID 16956385.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146425 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000096255 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8646886-5] Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (Jul 1996). "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q". Cytogenet Cell Genet. 73 (1–2): 153–6. doi:10.1159/000134329. PMID 8646886.

[pmid16260502-6] Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247 . PMID 16260502.

[entrez-7] 1 2 "Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1".

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DYNLT1

Related Research Articles

References

Further reading