DYNLT1

DYNLT1
Identifiers
Aliases	DYNLT1 , CW-1, TCTEL1, tctex-1, dynein light chain Tctex-type 1, TCTEX1
External IDs	OMIM: 601554; MGI: 98643; HomoloGene: 4754; GeneCards: DYNLT1; OMA:DYNLT1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q25.3 Start 158,636,474 bp [1] End 158,644,743 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 A1|17 3.97 cM Start 6,697,511 bp [2] End 6,703,695 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell epithelium of nasopharynx olfactory zone of nasal mucosa palpebral conjunctiva nasal epithelium oral cavity ganglionic eminence islet of Langerhans jejunal mucosa mucosa of paranasal sinus Top expressed in spermatid spermatocyte neural tube mesencephalon lens testicle islet of Langerhans granulocyte epiblast urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding cytoskeletal motor activity protein C-terminus binding Cellular component cytoplasm Golgi apparatus secretory vesicle spindle dynein complex cytoplasmic microtubule microtubule cytoskeleton host cell extracellular region cytoplasmic dynein complex secretory granule lumen ficolin-1-rich granule lumen mitochondrion lamellipodium soma axonal growth cone Biological process intracellular transport of viral protein in host cell regulation of G protein-coupled receptor signaling pathway negative regulation of neurogenesis nervous system development cell division establishment of mitotic spindle orientation microtubule-dependent intracellular transport of viral material towards nucleus viral entry into host cell cell cycle viral process transport of viral material towards nucleus neutrophil degranulation positive regulation of neuron projection development dendrite development positive regulation of Rac protein signal transduction negative regulation of mitochondrial membrane permeability regulation of GTPase activity neuron projection morphogenesis regulation of cytoskeleton organization negative regulation of cell death axon development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6993 21648 Ensembl ENSG00000146425 ENSMUSG00000096255 UniProt P63172 P51807 RefSeq (mRNA) NM_006519 NM_001291602 NM_001291603 NM_009342 RefSeq (protein) NP_001278531 NP_001278532 NP_006510 NP_001160099 NP_001186877 NP_001160102 NP_001160101 NP_033368 Location (UCSC) Chr 6: 158.64 – 158.64 Mb Chr 17: 6.7 – 6.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene. ^{[5] [6] [7]}

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM] ^[7]

In cancer patients, DYNLT1 expression has been linked to both higher and lower survival rates, depending on cancer type. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000146425 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000096255 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (Jul 1996). "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q". Cytogenet Cell Genet. 73 (1–2): 153–6. doi:10.1159/000134329. PMID   8646886.
6. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC   2171247 . PMID   16260502.
7. "Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1".
8. "Research update from the MCM team (March 2025)". World Community Grid. 18 March 2025. Retrieved 19 March 2025.

Further reading

• Tete R, de Montgolfier R, Piante M (1971). "[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]". Journal de Médecine de Lyon. 52 (192): 1523–6 passim. PMID   5503857.
• King SM, Dillman JF, Benashski SE, et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein". J. Biol. Chem. 271 (50): 32281–7. doi: 10.1074/jbc.271.50.32281 . PMID   8943288.
• Nagano F, Orita S, Sasaki T, et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi: 10.1074/jbc.273.46.30065 . PMID   9804756.
• Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription". J. Biol. Chem. 275 (4): 2399–403. doi: 10.1074/jbc.275.4.2399 . PMID   10644691.
• Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis". J. Biol. Chem. 277 (10): 7897–904. doi: 10.1074/jbc.M111937200 . PMID   11751937.
• Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. PMID   12009301. S2CID   11632830.
• Nadano D, Nakayama J, Matsuzawa S, et al. (2002). "Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton". Biochem. J. 364 (Pt 3): 669–77. doi:10.1042/BJ20011836. PMC   1222615 . PMID   12049630.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Machado RD, Rudarakanchana N, Atkinson C, et al. (2004). "Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension". Hum. Mol. Genet. 12 (24): 3277–86. doi: 10.1093/hmg/ddg365 . PMID   14583445.
• Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi: 10.1074/jbc.M311671200 . PMID   15117959.
• Ohka S, Matsuda N, Tohyama K, et al. (2004). "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome". J. Virol. 78 (13): 7186–98. doi:10.1128/JVI.78.13.7186-7198.2004. PMC   421661 . PMID   15194795.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• de Wit NJ, Verschuure P, Kappé G, et al. (2005). "Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1". Eur. J. Cell Biol. 83 (7): 337–45. doi:10.1078/0171-9335-00396. PMID   15503857.
• Chuang JZ, Yeh TY, Bollati F, et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth". Dev. Cell. 9 (1): 75–86. doi:10.1016/j.devcel.2005.04.003. PMC   3857739 . PMID   15992542.
• Yeh TY, Peretti D, Chuang JZ, et al. (2007). "Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin". Traffic. 7 (11): 1495–502. doi:10.1111/j.1600-0854.2006.00482.x. PMC   3873093 . PMID   16956385.