KIF7

KIF7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XT3, 4A14
Identifiers
Aliases	KIF7 , ACLS, HLS2, JBTS12, UNQ340, AGBK, kinesin family member 7
External IDs	OMIM: 611254 MGI: 1098239 HomoloGene: 72555 GeneCards: KIF7
Gene location (Human)
Chr.	Chromosome 15 (human)
End	89,655,467 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,365,468 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; gastric mucosa; ; stromal cell of endometrium; ; left uterine tube; ; canal of the cervix; ; subcutaneous adipose tissue; ; left coronary artery; ; sural nerve; ; ganglionic eminence; ; right atrium;
	Top expressed in
	hand; ; molar; ; foot; ; maxillary prominence; ; endocardial cushion; ; medullary collecting duct; ; renal corpuscle; ; vas deferens; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding ; microtubule motor activity ; nucleotide binding ; protein binding ; ATP binding ; plus-end-directed microtubule motor activity ; ATPase activity ;
Cellular component	cell projection ; ciliary tip ; cilium ; kinesin complex ; ciliary basal body ; cytoplasm ; cytoskeleton ; microtubule ;
Biological process	microtubule-based movement ; negative regulation of smoothened signaling pathway ; positive regulation of smoothened signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	374654
	16576
	ENSG00000166813
	ENSMUSG00000050382
	Q2M1P5
	B7ZNG0
	NM_198525
	NM_001291222 ; NM_010626
	NP_940927
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 17, 2022

Kinesin family member 7 (KIF7), also known as kinesin-4, is a human protein encoded by the gene KIF7. It is part of the kinesin family of motor proteins.

Function

KIF7 depolymerises the growing plus-end of microtubules, and is involved in regulating Hedgehog signalling.^[5]

Related Research Articles

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

Kinesin family member KIF18A is a human protein encoded by the KIF18A gene. It is part of the kinesin family of motor proteins.

Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.

Kinesin-like protein KIF13A is a protein that in humans is encoded by the KIF13A gene.

Kinesin heavy chain isoform 5C is a protein that in humans is encoded by the KIF5C gene.

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene. KIF17 and its close relative, C. elegans OSM-3, are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins. In contrast to heterotrimeric kinesin-2 motors, however, KIF17 and OSM-3 form distinct homodimeric complexes. Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane, whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.

KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene. The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.

Kinesin-like protein KIF3C is a protein that in humans is encoded by the KIF3C gene.

Kinesin family member 16B, also known as KIF16B, is a protein which in humans is encoded by the KIF16B gene.

Desert hedgehog, also Desert hedgehog homolog or Dhh, is a protein encoded by the DHH gene, and is a member of the hedgehog signaling pathway. The human homolog (DHH) is on chromosome band 12q13.1. The protein encoded by this gene is involved in cell signaling. The several mammalian variants of the Drosophila hedgehog gene have been named after the various species of hedgehog; the desert hedgehog is honored by this one. The gene is not specific to desert hedgehogs.

Kinesin family member 6 is a protein that in humans is encoded by the KIF6 gene. This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport.

Kinesin family member 13B is a protein that in humans is encoded by the KIF13B gene.

KIF4B is a human protein encoded by the gene KIF4B. It is part of the kinesin family of proteins, which are motor proteins involved in many cellular processes.

Kinesin family member 9 (KIF9), also known as kinesin-9, is a human protein encoded by the KIF9 gene. It is part of the kinesin family of motor proteins.

Kinesin family member 12 (KIF12), also known as kinesin-12, is a human protein encoded by the gene KIF12. It is part of the kinesin family of motor proteins.

Kinesin family member 19 (KIF19) is a protein in humans encoded by the KIF19 gene. It is part of the kinesin family of motor proteins.

Kinesin family member 25 (KIF25), also known as kinesin-14, is a human protein encoded by the KIF25 gene. It is part of the kinesin family of motor proteins.

Kinesin family member 27 (KIF27), also known as kinesin-4, is a human protein encoded by the KIF27 gene. It is part of the kinesin family of motor proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166813 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050382 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ He M, Subramanian R, Bangs F, Omelchenko T, Liem KF, Kapoor TM, Anderson KV (July 2014). "The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment". Nature Cell Biology. 16 (7): 663–672. doi:10.1038/ncb2988. PMC 4085576 . PMID 24952464.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166813 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050382 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] He M, Subramanian R, Bangs F, Omelchenko T, Liem KF, Kapoor TM, Anderson KV (July 2014). "The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment". Nature Cell Biology. 16 (7): 663–672. doi:10.1038/ncb2988. PMC 4085576 . PMID 24952464.

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