KIF25

KIF25
Identifiers
Aliases	KIF25 , KNSL3, kinesin family member 25
External IDs	OMIM: 603815 HomoloGene: 49939 GeneCards: KIF25
Gene location (Human)
Chr.	Chromosome 6 (human)
End	168,045,091 bp
RNA expression pattern
	Top expressed in
	abdominal fat; ; putamen; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; caudate nucleus; ; substantia nigra; ; nucleus accumbens; ; prefrontal cortex; ; amygdala; ; hypothalamus;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding ; microtubule motor activity ; nucleotide binding ; ATPase activity ; ATP binding ; minus-end-directed microtubule motor activity ;
Cellular component	cytoplasm ; microtubule ; cytoskeleton ; kinesin complex ; centrosome ; microtubule organizing center ;
Biological process	microtubule-based movement ; negative regulation of autophagy ; organelle organization ; mitotic sister chromatid segregation ; negative regulation of mitotic centrosome separation ; protein homotetramerization ; establishment of spindle orientation ; nucleus localization ;
	Sources:Amigo / QuickGO
Orthologs
	3834
	n/a
	ENSG00000125337
	n/a
	Q9UIL4
	n/a
	NM_005355 ; NM_030615
	n/a
	NP_005346 ; NP_085118
	n/a
	Wikidata
View/Edit Human

Last updated December 05, 2022

Kinesin family member 25 (KIF25), also known as kinesin-14, is a human protein encoded by the KIF25 gene. It is part of the kinesin family of motor proteins.

Function

KIF25 is a minus-end directed microtubule motor protein, and its activity delays the separation of chromosomes during mitosis.^[3]

Related Research Articles

Kinesin-1 heavy chain is a protein that in humans is encoded by the KIF5B gene.

Chromosome-associated kinesin KIF4A is a protein that in humans is encoded by the KIF4A gene.

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene.

Kinesin-like protein KIF21A is a protein that in humans is encoded by the KIF21A gene.

Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene. KIF3B is an N-type protein that complexes with two other kinesin proteins to form two-headed anterograde motors. First, KIF3B forms a heterodimer with KIF3A ; (KIF3A/3B), that is membrane-bound and has ATPase activity. Then KIFAP3 binds to the tail domain to form a heterotrimeric motor. This motor has a plus end-directed microtubule sliding activity that exhibits a velocity of ∼0.3 μm/s a. There are 14 kinesin protein families in the kinesin superfamily and KIF3B is part of the Kinesin-2 family, of kinesins that can all form heterotrimeric complexes. Expression of the three motor subunits is ubiquitous. The KIG3A/3B/KAP3 motors can transport 90 to 160 nm in diameter organelles.

Kinesin heavy chain isoform 5A is a protein that in humans is encoded by the KIF5A gene.

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.

Kinesin heavy chain isoform 5C is a protein that in humans is encoded by the KIF5C gene.

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene. KIF17 and its close relative, C. elegans OSM-3, are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins. In contrast to heterotrimeric kinesin-2 motors, however, KIF17 and OSM-3 form distinct homodimeric complexes. Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane, whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.

Kinesin-like protein KIF3C is a protein that in humans is encoded by the KIF3C gene.

Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene.

Kinesin family member 6 is a protein that in humans is encoded by the KIF6 gene. This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport.

KIF4B is a human protein encoded by the gene KIF4B. It is part of the kinesin family of proteins, which are motor proteins involved in many cellular processes.

Kinesin family member 7 (KIF7), also known as kinesin-4, is a human protein encoded by the gene KIF7. It is part of the kinesin family of motor proteins.

Kinesin family member 9 (KIF9), also known as kinesin-9, is a human protein encoded by the KIF9 gene. It is part of the kinesin family of motor proteins.

Kinesin family member 12 (KIF12), also known as kinesin-12, is a human protein encoded by the gene KIF12. It is part of the kinesin family of motor proteins.

Kinesin family member 19 (KIF19) is a protein in humans encoded by the KIF19 gene. It is part of the kinesin family of motor proteins.

Kinesin family member 27 (KIF27), also known as kinesin-4, is a human protein encoded by the KIF25 gene. It is part of the kinesin family of motor proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125337 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L (April 2017). "The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation". Nature Cell Biology. 19 (4): 384–390. doi:10.1038/ncb3486. PMC 5376238 . PMID 28263957.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000125337 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L (April 2017). "The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation". Nature Cell Biology. 19 (4): 384–390. doi:10.1038/ncb3486. PMC 5376238 . PMID 28263957.

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