TPM4

TPM4
Identifiers
Aliases	TPM4 , HEL-S-108, tropomyosin 4
External IDs	OMIM: 600317 HomoloGene: 100849 GeneCards: TPM4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	16,103,002 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right coronary artery; ; gallbladder; ; ascending aorta; ; left uterine tube; ; smooth muscle tissue; ; left coronary artery; ; right lung; ; upper lobe of left lung; ; canal of the cervix;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding ; actin binding ; structural constituent of muscle ; protein binding ; metal ion binding ; identical protein binding ; protein homodimerization activity ; protein heterodimerization activity ; actin filament binding ;
Cellular component	cytoplasm ; filamentous actin ; podosome ; cytosol ; muscle thin filament tropomyosin ; cortical cytoskeleton ; extracellular exosome ; cytoskeleton ; membrane ; stress fiber ; focal adhesion ; actin filament ; actin cytoskeleton ;
Biological process	osteoblast differentiation ; muscle filament sliding ; muscle contraction ; actin filament organization ;
	Sources:Amigo / QuickGO
Orthologs
	7171
	n/a
	ENSG00000167460
	n/a
	P67936
	n/a
	NM_001145160 ; NM_003290 ; NM_001367836 ; NM_001367837 ; NM_001367838
	n/a
	NP_001138632 ; NP_003281 ; NP_001354765 ; NP_001354766 ; NP_001354767
	n/a
	Wikidata
View/Edit Human

Last updated September 30, 2022

Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.^[3]^[4]

Related Research Articles

Tropomyosin is a two-stranded alpha-helical, coiled coil protein found in actin-based cytoskeletons.

Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin (Tm) family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells.

Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.

β-Tropomyosin, also known as tropomyosin beta chain is a protein that in humans is encoded by the TPM2 gene. β-tropomyosin is striated muscle-specific coiled coil dimer that functions to stabilize actin filaments and regulate muscle contraction.

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.

Myb-binding protein 1A is a protein that in humans is encoded by the MYBBP1A gene.

Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the PRPF19 gene.

Phosphofructokinase, platelet, also known as PFKP is an enzyme which in humans is encoded by the PFKP gene.

RNA-binding protein 4 is a protein that in humans is encoded by the RBM4 gene.

60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene.

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.

Nucleosome assembly protein 1-like 1 is a protein that in humans is encoded by the NAP1L1 gene.

DnaJ homolog subfamily B member 11 is a protein that in humans is encoded by the DNAJB11 gene.

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene.

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.

Putative rRNA methyltransferase 3 is an enzyme that in humans is encoded by the FTSJ3 gene.

Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167460 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wilton SD, Lim L, Dorosz SD, Gunn HC, Eyre HJ, Callen DF, Laing NG (Jul 1996). "Assignment of the human alpha-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (4): 294–6. doi:10.1159/000134206. PMID 8641132.
↑ "Entrez Gene: TPM4 tropomyosin 4".

Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
MacLeod AR, Talbot K, Smillie LB, Houlker C (1987). "Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin". J. Mol. Biol. 194 (1): 1–10. doi:10.1016/0022-2836(87)90710-8. PMID 3612796.
MacLeod AR, Houlker C, Reinach FC, et al. (1986). "A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 7835–9. doi: 10.1073/pnas.82.23.7835 . PMC 390864 . PMID 3865200.
Lawrence B, Perez-Atayde A, Hibbard MK, et al. (2000). "TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors". Am. J. Pathol. 157 (2): 377–84. doi:10.1016/S0002-9440(10)64550-6. PMC 1850130 . PMID 10934142.
Meech SJ, McGavran L, Odom LF, et al. (2001). "Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion". Blood. 98 (4): 1209–16. doi: 10.1182/blood.V98.4.1209 . PMID 11493472.
Yi J, Kloeker S, Jensen CC, et al. (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". J. Biol. Chem. 277 (11): 9580–9. doi: 10.1074/jbc.M106922200 . PMID 11782456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884 . PMID 15456888.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167460 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8641132-3] Wilton SD, Lim L, Dorosz SD, Gunn HC, Eyre HJ, Callen DF, Laing NG (Jul 1996). "Assignment of the human alpha-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (4): 294–6. doi:10.1159/000134206. PMID 8641132.

[entrez-4] "Entrez Gene: TPM4 tropomyosin 4".

[1]

[2]

[3]

[4]

TPM4

Related Research Articles

References

Further reading