KRT38

KRT38
Identifiers
Aliases	KRT38 , HA8, KRTHA8, hHa8, keratin 38
External IDs	OMIM: 604542; HomoloGene: 68361; GeneCards: KRT38; OMA:KRT38 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,440,983 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; skin of thigh; ; skin of abdomen; ; pharynx; ; tonsil; ; head; ; gonad; ; mouth; ; mucosa of esophagus; ; salivary gland;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; structural molecule activity ;
Cellular component	intermediate filament ; extracellular exosome ; cytosol ;
Biological process	keratinization ; cornification ;
	Sources:Amigo / QuickGO
Orthologs
	8687
	n/a
	ENSG00000171360
	n/a
	O76015
	n/a
	NM_006771
	n/a
	NP_006762
	n/a
	Wikidata
View/Edit Human

Last updated August 15, 2024

KRT38 is a keratin gene. Its corresponding protein is asymmetrically distributed within human hair follicles.^[3] It does not have murine^[4] or equine^[5] orthologs. The encoded protein is a type I keratin and a hair keratin.

Related Research Articles

Keratin 6A is one of the 27 different type II keratins expressed in humans. Keratin 6A was the first type II keratin sequence determined. Analysis of the sequence of this keratin together with that of the first type I keratin led to the discovery of the four helical domains in the central rod of keratins. In humans Keratin 6A is encoded by the KRT6A gene.

Keratin, type I cytoskeletal 19 (Keratin-19)) also known as cytokeratin-19 (CK-19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin-19 is a type I keratin.

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.

Keratin 15 is a protein that in humans is encoded by the KRT15 gene. It has also been referred to as cytokeratin 15, K1CO and KRTB.

Keratin 6C, is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. This gene was uncovered recently by the Human Genome Project and its expression patterns in humans remains unknown.

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.

Keratin, type I cuticular Ha1 is a protein that in humans is encoded by the KRT31 gene.

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.

Keratin, type I cuticular Ha3-II is a protein that in humans is encoded by the KRT33B gene.

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.

Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.

Keratin 83, also known as KRT83, is a protein which humans is encoded by the KRT83 gene.

Keratin 79 also known as KRT79 is a protein which humans is encoded by the KRT79 gene.

KRT71 is a keratin gene. Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171360 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Westgate GE, Ginger RS, Green MR (June 2017). "The biology and genetics of curly hair". Experimental Dermatology. 26 (6): 483–490. doi: 10.1111/exd.13347 . hdl: 10454/14702 . PMID 28370528. S2CID 44671559.
↑ Takan I, Karakülah G, Louka A, Pavlopoulou A (17 March 2023). ""In the light of evolution:" keratins as exceptional tumor biomarkers". PeerJ. 11: e15099. doi: 10.7717/peerj.15099 . PMC 10026720 . PMID 36949761.
↑ Balmer P, Bauer A, Pujar S, McGarvey KM, Welle M, Galichet A, et al. (28 August 2017). "A curated catalog of canine and equine keratin genes". PLOS ONE. 12 (8): e0180359. Bibcode:2017PLoSO..1280359B. doi: 10.1371/journal.pone.0180359 . PMC 5573215 . PMID 28846680.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171360 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Westgate GE, Ginger RS, Green MR (June 2017). "The biology and genetics of curly hair". Experimental Dermatology. 26 (6): 483–490. doi: 10.1111/exd.13347 . hdl: 10454/14702 . PMID 28370528. S2CID 44671559.

[4] Takan I, Karakülah G, Louka A, Pavlopoulou A (17 March 2023). ""In the light of evolution:" keratins as exceptional tumor biomarkers". PeerJ. 11: e15099. doi: 10.7717/peerj.15099 . PMC 10026720 . PMID 36949761.

[5] Balmer P, Bauer A, Pujar S, McGarvey KM, Welle M, Galichet A, et al. (28 August 2017). "A curated catalog of canine and equine keratin genes". PLOS ONE. 12 (8): e0180359. Bibcode:2017PLoSO..1280359B. doi: 10.1371/journal.pone.0180359 . PMC 5573215 . PMID 28846680.

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