TUBGCP2

TUBGCP2
Identifiers
Aliases	TUBGCP2 , GCP-2, GCP2, Grip103, SPBC97, Spc97p, h103p, hGCP2, hSpc97, tubulin gamma complex associated protein 2, ALP4, SPC97, PAMDDFS
External IDs	OMIM: 617817 MGI: 1921487 HomoloGene: 55980 GeneCards: TUBGCP2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,318,823 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,616,582 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; skin of abdomen; ; anterior pituitary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; left uterine tube; ; spleen; ; right lung; ; canal of the cervix; ; tibial nerve;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; maxillary prominence; ; spermatid; ; somite; ; autopod region; ; hand; ; dermis; ; foot; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton ; protein binding ; microtubule minus-end binding ; gamma-tubulin binding ;
Cellular component	cytoplasm ; cytosol ; centrosome ; spindle pole ; equatorial microtubule organizing center ; membrane ; nucleoplasm ; microtubule organizing center ; gamma-tubulin small complex ; spindle pole body ; cytoplasmic microtubule ; cytoskeleton ; microtubule ; gamma-tubulin complex ;
Biological process	centrosome duplication ; microtubule nucleation by interphase microtubule organizing center ; mitotic spindle assembly ; cytoplasmic microtubule organization ; microtubule cytoskeleton organization ; microtubule nucleation ; meiosis ; mitotic cell cycle ; spindle assembly ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	10844
	74237
	ENSG00000130640
	ENSMUSG00000025474
	Q9BSJ2
	Q921G8
	NM_001256617 ; NM_001256618 ; NM_006659
	NM_001286007 ; NM_001286009 ; NM_001286011 ; NM_133755
	NP_001243546 ; NP_001243547 ; NP_006650
	NP_001272936 ; NP_001272938 ; NP_001272940 ; NP_598516
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 13, 2023

Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene.^[5]^[6] It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome.

Related Research Articles

Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize into microtubules, a major component of the eukaryotic cytoskeleton. Microtubules function in many essential cellular processes, including mitosis. Tubulin-binding drugs kill cancerous cells by inhibiting microtubule dynamics, which are required for DNA segregation and therefore cell division.

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.

Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.

Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene.

Tubulin alpha-1C chain is a protein that in humans is encoded by the TUBA1C gene.

Tubulin-folding cofactor B is a protein that in humans is encoded by the TBCB gene.

Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.

Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

Gamma-tubulin complex component 5 is a protein that in humans is encoded by the TUBGCP5 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.

Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.

Dystrobrevin beta is a protein which in humans is encoded by the DTNB gene.

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. Its function appears two be twofold: CEP164 is required for primary cilium formation. Furthermore, it is an important component in the response to DNA damage by UV light.

Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.

Centrosomal protein of 78 kDa, also known as Cep78, is a protein that in humans is encoded by the CEP78 gene.

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene. It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130640 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025474 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Murphy SM, Urbani L, Stearns T (Jun 1998). "The Mammalian γ-Tubulin Complex Contains Homologues of the Yeast Spindle Pole Body Components Spc97p and Spc98p". J Cell Biol. 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743 . PMID 9566967.
↑ "Entrez Gene: TUBGCP2 tubulin, gamma complex associated protein 2".

Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752 . PMID 14759258.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155 . PMID 12221128.
Murphy SM, Preble AM, Patel UK, et al. (2002). "GCP5 and GCP6: Two New Members of the Human γ-Tubulin Complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259 . PMID 11694571.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130640 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025474 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9566967-5] Murphy SM, Urbani L, Stearns T (Jun 1998). "The Mammalian γ-Tubulin Complex Contains Homologues of the Yeast Spindle Pole Body Components Spc97p and Spc98p". J Cell Biol. 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743 . PMID 9566967.

[entrez-6] "Entrez Gene: TUBGCP2 tubulin, gamma complex associated protein 2".

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TUBGCP2

Contents

See also

Related Research Articles

References

Further reading