Centrin 1

CETN1
Identifiers
Aliases	CETN1 , CEN1, CETN, centrin 1
External IDs	OMIM: 603187 MGI: 1347086 HomoloGene: 105668 GeneCards: CETN1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	582,114 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	9,619,478 bp
RNA expression pattern
	Top expressed in
	sperm; ; human musculoskeletal system; ; muscular system; ; muscle; ; muscle; ; gland; ; human thorax; ; male reproductive gland; ; integument; ; prostate;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; motor neuron; ; submandibular gland; ; spinal ganglia; ; carotid body; ; trachea; ; triceps brachii muscle; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding ; calcium ion binding ; G-protein beta/gamma-subunit complex binding ; heterotrimeric G-protein binding ; protein binding ; metal ion binding ;
Cellular component	cytoplasm ; microtubule organizing center ; centrosome ; spindle pole ; cytoskeleton ; photoreceptor connecting cilium ; centriole ; nucleus ;
Biological process	cell cycle ; cellular response to heat ; cell division ; mitotic cytokinesis ; centriole replication ; regulation of centrosome duplication ; calcium-mediated signaling ; regulation of cytokinesis ; microtubule cytoskeleton organization ; nucleotide-excision repair ; mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	1068
	26369
	ENSG00000177143
	ENSMUSG00000050996
	Q12798
	P41209
	NM_004066
	NM_007593
	NP_004057
	NP_031619
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 15, 2024

Centrin-1 is a protein that in humans is encoded by the CETN1 gene.^[5]^[6] It belongs to the centrin family of proteins.

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.^[6]

Related Research Articles

Centrin-2 is a protein that in humans is encoded by the CETN2 gene. It belongs to the centrin family of proteins.

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.

Ninein is a protein that in humans is encoded by the NIN gene.

Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene.

40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.

Centrin-3 is a protein that in humans is encoded by the CETN3 gene. It belongs to the centrin family of proteins.

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.

Secretory carrier-associated membrane protein 2 is a protein that in humans is encoded by the SCAMP2 gene.

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.

Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.

Actin-like protein 7A is a protein that in humans is encoded by the ACTL7A gene.

Ninein-like protein is a protein that in humans is encoded by the NINL gene. It is part of the centrosome.

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. Its function appears two be twofold: CEP164 is required for primary cilium formation. Furthermore, it is an important component in the response to DNA damage by UV light.

Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177143 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050996 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Errabolu R, Sanders MA, Salisbury JL (Jun 1994). "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles". J Cell Sci. 107. ( Pt 1): 9–16. doi: 10.1242/jcs.107.1.9 . PMID 8175926.
1 2 "Entrez Gene: CETN1 centrin, EF-hand protein, 1".

External links

Human CETN1 genome location and CETN1 gene details page in the UCSC Genome Browser .

Tsang WY, Spektor A, Luciano DJ, et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability". Mol. Biol. Cell. 17 (8): 3423–34. doi:10.1091/mbc.E06-04-0371. PMC 1525247 . PMID 16760425.
Zhao ZS, Lim JP, Ng YW, et al. (2006). "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A". Mol. Cell. 20 (2): 237–49. doi: 10.1016/j.molcel.2005.08.035 . hdl: 10536/DRO/DU:30131061 . PMID 16246726.
Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET". Traffic. 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678. S2CID 36574274.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Lutz W, Lingle WL, McCormick D, et al. (2001). "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication". J. Biol. Chem. 276 (23): 20774–80. doi: 10.1074/jbc.M101324200 . PMID 11279195.
Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro". J. Cell Sci. 113. ( Pt 8) (8): 1355–64. doi:10.1242/jcs.113.8.1355. PMID 10725219.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177143 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050996 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8175926-5] Errabolu R, Sanders MA, Salisbury JL (Jun 1994). "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles". J Cell Sci. 107. ( Pt 1): 9–16. doi: 10.1242/jcs.107.1.9 . PMID 8175926.

[entrez-6] 1 2 "Entrez Gene: CETN1 centrin, EF-hand protein, 1".

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Centrin 1

Contents

Related Research Articles

References

External links

Further reading