MAP4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | MAP4 , microtubule associated protein 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 157132; MGI: 97178; HomoloGene: 1780; GeneCards: MAP4; OMA:MAP4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene. [5]
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported. [6] uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells. [7] oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles. [8] mMAP4 is a muscle-specific isoform. [8] [9]