MAP4

Last updated

MAP4
Identifiers
Aliases MAP4 , microtubule associated protein 4
External IDs OMIM: 157132; MGI: 97178; HomoloGene: 1780; GeneCards: MAP4; OMA:MAP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134364
NM_001134365
NM_002375
NM_030884
NM_030885

RefSeq (protein)

NP_001127836
NP_002366
NP_112147

Location (UCSC) Chr 3: 47.85 – 48.09 Mb Chr 9: 109.93 – 110.08 Mb
PubMed search [3] [4]
Wikidata
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Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene. [5]

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported. [6] uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells. [7] oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles. [8] mMAP4 is a muscle-specific isoform. [8] [9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000047849 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032479 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chapin SJ, Bulinski JC (Jul 1991). "Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau". J Cell Sci. 98. ( Pt 1): 27–36. doi:10.1242/jcs.98.1.27. PMID   1905296.
  6. "Entrez Gene: MAP4 microtubule-associated protein 4".
  7. Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID   21822276. S2CID   8869880.
  8. 1 2 Mogessie B, Roth D, Rahil Z, Straube A (21 April 2015). "A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation". eLife. 4 e05697. doi: 10.7554/eLife.05697 . PMC   4423121 . PMID   25898002.
  9. Casey LM, Lyon HD, Olmsted JB (April 2003). "Muscle-specific microtubule-associated protein 4 is expressed early in myogenesis and is not sufficient to induce microtubule reorganization". Cell Motility and the Cytoskeleton. 54 (4): 317–36. doi:10.1002/cm.10105. PMID   12601693.

Further reading