TUBB1

TUBB1
Identifiers
Aliases	TUBB1 , tubulin beta 1 class VI, MACTHC1
External IDs	OMIM: 612901; MGI: 107814; HomoloGene: 69474; GeneCards: TUBB1; OMA:TUBB1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.32 Start 59,019,429 bp [1] End 59,026,654 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H4 Start 174,292,488 bp [2] End 174,299,675 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte trabecular bone blood granulocyte bone marrow testicle bone marrow cells right lung spleen islet of Langerhans Top expressed in blood spleen body of femur right lung lobe embryo yolk sac bone marrow abdominal wall endocardial cushion embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding structural constituent of cytoskeleton GTPase activity Cellular component cytoplasm microtubule extracellular exosome cytoskeleton microtubule cytoskeleton Biological process spindle assembly microtubule-based process microtubule cytoskeleton organization mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81027 545486 Ensembl ENSG00000101162 ENSMUSG00000016255 UniProt Q9H4B7 A2AQ07 RefSeq (mRNA) NM_030773 NM_001080971 RefSeq (protein) NP_110400 NP_001074440 Location (UCSC) Chr 20: 59.02 – 59.03 Mb Chr 2: 174.29 – 174.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000101162 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000016255 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TUBB1 tubulin, beta 1".

Further reading

• Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC   2180222 . PMID   10908577.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC   139103 . PMID   12486001.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Yanagida M, Hayano T, Yamauchi Y, et al. (2004). "Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes". J. Biol. Chem. 279 (3): 1607–14. doi: 10.1074/jbc.M305604200 . PMID   14583623.
• Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID   15304323. S2CID   8403635.
• Schulze H, Korpal M, Bergmeier W, et al. (2005). "Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions". Blood. 104 (13): 3949–57. doi: 10.1182/blood-2004-03-1179 . PMID   15315966.
• Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–204. doi: 10.1074/jbc.M406195200 . PMID   15331610.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology. 2: 5. doi: 10.1186/1742-4690-2-5 . PMC   549075 . PMID   15691386.
• Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology. 2: 7. doi: 10.1186/1742-4690-2-7 . PMC   549042 . PMID   15698476.
• Freson K, De Vos R, Wittevrongel C, et al. (2005). "The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure". Blood. 106 (7): 2356–62. doi: 10.1182/blood-2005-02-0723 . PMID   15956286.
• Mesquita B, Veiga I, Pereira D, et al. (2006). "No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin". BMC Cancer. 5: 101. doi: 10.1186/1471-2407-5-101 . PMC   1199587 . PMID   16095531.
• Coiras M, Camafeita E, Ureña T, et al. (2006). "Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression". Proteomics. 6 (Suppl 1): S63–73. doi:10.1002/pmic.200500437. PMID   16526095. S2CID   42878271.
• Navarro-Núñez L, Lozano ML, Rivera J, et al. (2007). "The association of the beta1-tubulin Q43P polymorphism with intracerebral hemorrhage in men". Haematologica. 92 (4): 513–8. doi: 10.3324/haematol.10689 . PMID   17488662.