TUBB1

TUBB1
Identifiers
Aliases	TUBB1 , tubulin beta 1 class VI, MACTHC1
External IDs	OMIM: 612901 MGI: 107814 HomoloGene: 69474 GeneCards: TUBB1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	59,026,654 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	174,299,675 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spongy bone; ; blood; ; bone marrow; ; bone marrow cells; ; right lung; ; spleen; ; islet of Langerhans; ; sperm; ; upper lobe of left lung;
	Top expressed in
	blood; ; spleen; ; body of femur; ; right lung lobe; ; yolk sac; ; bone marrow; ; abdominal wall; ; endocardial cushion; ; artery; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; structural constituent of cytoskeleton ; GTPase activity ;
Cellular component	cytoplasm ; microtubule ; extracellular exosome ; cytoskeleton ; microtubule cytoskeleton ;
Biological process	spindle assembly ; microtubule-based process ; microtubule cytoskeleton organization ; mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	81027
	545486
	ENSG00000101162
	ENSMUSG00000016255
	Q9H4B7
	A2AQ07
	NM_030773
	NM_001080971
	NP_110400
	NP_001074440
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans.^[5]

Related Research Articles

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Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.

Tubulin beta-4A chain is a protein that in humans is encoded by the TUBB4A gene. Two tubulin beta-4 chain proteins are encoded in the human genome by the genes TUBB4A and TUBB4B. Tubulin is the major constituent of microtubules, a key components of the cytoskeleton. It binds two molecules of GTP, one at an exchangeable site on the beta-chain and one at a non-exchangeable site on the alpha-chain. TUBB4A is preferentially and highly expressed in the central nervous system.

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Tubulin alpha-1C chain is a protein that in humans is encoded by the TUBA1C gene.

Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene. It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome.

Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.

Protein arginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene.

Protein HEXIM2 is a protein that in humans is encoded by the HEXIM2 gene.

Tubulin-specific chaperone A is a protein that in humans is encoded by the TBCA gene.

Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.

Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101162 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016255 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TUBB1 tubulin, beta 1".

Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222 . PMID 10908577.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103 . PMID 12486001.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Yanagida M, Hayano T, Yamauchi Y, et al. (2004). "Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes". J. Biol. Chem. 279 (3): 1607–14. doi: 10.1074/jbc.M305604200 . PMID 14583623.
Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323. S2CID 8403635.
Schulze H, Korpal M, Bergmeier W, et al. (2005). "Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions". Blood. 104 (13): 3949–57. doi: 10.1182/blood-2004-03-1179 . PMID 15315966.
Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–204. doi: 10.1074/jbc.M406195200 . PMID 15331610.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology. 2: 5. doi: 10.1186/1742-4690-2-5 . PMC 549075 . PMID 15691386.
Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology. 2: 7. doi: 10.1186/1742-4690-2-7 . PMC 549042 . PMID 15698476.
Freson K, De Vos R, Wittevrongel C, et al. (2005). "The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure". Blood. 106 (7): 2356–62. doi: 10.1182/blood-2005-02-0723 . PMID 15956286.
Mesquita B, Veiga I, Pereira D, et al. (2006). "No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin". BMC Cancer. 5: 101. doi: 10.1186/1471-2407-5-101 . PMC 1199587 . PMID 16095531.
Coiras M, Camafeita E, Ureña T, et al. (2006). "Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression". Proteomics. 6 (Suppl 1): S63–73. doi:10.1002/pmic.200500437. PMID 16526095. S2CID 42878271.
Navarro-Núñez L, Lozano ML, Rivera J, et al. (2007). "The association of the beta1-tubulin Q43P polymorphism with intracerebral hemorrhage in men". Haematologica. 92 (4): 513–8. doi: 10.3324/haematol.10689 . PMID 17488662.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101162 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016255 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TUBB1 tubulin, beta 1".

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TUBB1

Related Research Articles

References

Further reading