MYO18B

MYO18B
Identifiers
Aliases	MYO18B , KFS4, myosin XVIIIB
External IDs	OMIM: 607295; MGI: 1921626; HomoloGene: 53435; GeneCards: MYO18B; OMA:MYO18B - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.1 Start 25,742,144 bp [1] End 26,031,045 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 112,836,742 bp [2] End 113,044,228 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle muscle of thigh Skeletal muscle tissue of rectus abdominis left ventricle Skeletal muscle tissue of biceps brachii right auricle of heart quadriceps femoris muscle vastus lateralis muscle right ventricle Top expressed in muscle of thigh esophagus spermatid lip skeletal muscle tissue lens embryo quadriceps femoris muscle superior frontal gyrus heart More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding actin binding cytoskeletal motor activity ATP binding microtubule motor activity microtubule binding Cellular component cytoplasm unconventional myosin complex sarcomere nucleus myosin complex Z discdkac filamentous actin Biological process microtubule-based movement vasculogenesis in utero embryonic development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84700 74376 Ensembl ENSG00000133454 ENSMUSG00000072720 UniProt Q8IUG5 n/a RefSeq (mRNA) NM_032608 NM_001318245 NM_028901 RefSeq (protein) NP_001305174 NP_115997 n/a Location (UCSC) Chr 22: 25.74 – 26.03 Mb Chr 5: 112.84 – 113.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene. ^{[5] [6] [7]}

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000133454 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000072720 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A. 99 (19): 12269–74. Bibcode:2002PNAS...9912269N. doi: 10.1073/pnas.192445899 . PMC   129434 . PMID   12209013.
6. Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol. 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID   12547197.
7. "Entrez Gene: MYO18B myosin XVIIIB".

Further reading

• Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells". Clin. Exp. Metastasis. 20 (3): 189–93. doi:10.1023/A:1022978932215. PMID   12741677. S2CID   22741542.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Yanaihara N, Nishioka M, Kohno T, et al. (2004). "Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer". Int. J. Cancer. 112 (1): 150–4. doi: 10.1002/ijc.20339 . PMID   15305387. S2CID   25091930.
• Inoue T, Kon T, Ajima R, et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 342 (3): 829–34. doi:10.1016/j.bbrc.2006.02.025. PMID   16499872.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Edakuni N, Ikuta K, Yano S, et al. (2007). "Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice". Oncol. Res. 16 (5): 235–43. doi: 10.3727/000000006783981062 . PMID   17294804.