MYL6

MYL6
Identifiers
Aliases	MYL6 , ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM, myosin light chain 6
External IDs	OMIM: 609931 MGI: 109318 HomoloGene: 69080 GeneCards: MYL6
Gene location (Human)
Chr.	Chromosome 12 (human) [1]
End	56,163,496 bp [1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse) [2]
End	128,494,145 bp [2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• actin-dependent ATPase activity ; • calcium ion binding ; • structural constituent of muscle ; • cellular motor activity ; • GO:0001948 protein binding ;
Cellular component	• vesicle ; • cytosol ; • unconventional myosin complex ; • extracellular exosome ; • membrane ; • brush border ; • myosin complex ; • extracellular matrix ;
Biological process	• muscle contraction ; • skeletal muscle tissue development ; • muscle filament sliding ;
	Sources:Amigo / QuickGO
Orthologs
	4637
	17904
	ENSG00000092841
	ENSMUSG00000090841
	P60660
	Q60605
	NM_079425 ; NM_021019 ; NM_079423
	NM_010860 ; NM_001317217 ; NM_001317218 ; NM_001317219 ; NM_001317220
	NP_066299 ; NP_524147
	NP_001304146 ; NP_001304147 ; NP_001304148 ; NP_001304149 ; NP_034990
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 13, 2020

Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.^[5]^[6]^[7]^[8]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.^[8]

Related Research Articles

Myosin regulatory light polypeptide 9 is a protein that in humans is encoded by the MYL9 gene.

Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.

Myosin-11 is a protein that in humans is encoded by the MYH11 gene.

Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene. This cardiac ventricular/slow skeletal ELC isoform is distinct from that expressed in fast skeletal muscle (MYL1) and cardiac atrial muscle (MYL4). Ventricular ELC is part of the myosin molecule and is important in modulating cardiac muscle contraction.

Myosin-2 is a protein that in humans is encoded by the MYH2 gene.

Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases.

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.

Calmodulin-like protein 3 is a protein that in humans is encoded by the CALML3 gene.

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.

Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.

Protein phosphatase 1 regulatory subunit 12B is an enzyme that in humans is encoded by the PPP1R12B gene.

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.

SPEG complex locus, also known as SPEG, is a human gene.

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.

Myosin regulatory light chain 12A is a protein that in humans is encoded by the MYL12A gene.

Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene.

Myosin-15 also known as myosin, heavy chain 15 is a protein that in humans is encoded by the MYH15 gene.

Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene.

Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000092841 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090841 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bora PS, Bora NS, Wu X, Kaplan HJ, Lange LG (Jun 1994). "Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA". Genomics. 19 (1): 186–8. doi:10.1006/geno.1994.1041. PMID 8188229.
↑ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973 . PMID 2304459.
↑ Lenz S, Lohse P, Seidel U, Arnold HH (Jun 1989). "The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways". J Biol Chem. 264 (15): 9009–15. PMID 2722814.
1 2 "Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle".

Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition". J. Cell Sci. 109 (8): 2089–99. PMID 8856505.
Watanabe M, Kohri M, Takaishi M, et al. (2001). "Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells". Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi. 37 (1): 25–38. doi: 10.1540/jsmr.37.25 . PMID 11436981.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Fu ZY, Xie BT, Ma YT, Gong ZX (2006). "Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies". Acta Biochim. Biophys. Sin. (Shanghai). 38 (9): 625–32. doi: 10.1111/j.1745-7270.2006.00203.x . PMID 16953301.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000092841 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090841 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8188229-5] Bora PS, Bora NS, Wu X, Kaplan HJ, Lange LG (Jun 1994). "Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA". Genomics. 19 (1): 186–8. doi:10.1006/geno.1994.1041. PMID 8188229.

[pmid2304459-6] Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973 . PMID 2304459.

[pmid2722814-7] Lenz S, Lohse P, Seidel U, Arnold HH (Jun 1989). "The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways". J Biol Chem. 264 (15): 9009–15. PMID 2722814.

[entrez-8] 1 2 "Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle".

MYL6

Related Research Articles

References

Further reading