KRT71

KRT71
Identifiers
Aliases	KRT71 , HYPT13, K6IRS1, KRT6IRS, KRT6IRS1, keratin 71
External IDs	OMIM: 608245 MGI: 1861586 HomoloGene: 88864 GeneCards: KRT71
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,553,145 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,651,544 bp
RNA expression pattern
	Top expressed in
	nipple; ; skin of abdomen; ; right lung; ; spinal cord; ; human musculoskeletal system; ; muscular system; ; muscle; ; blood; ; mesencephalon; ; substantia nigra;
	Top expressed in
	lip; ; hair follicle; ; skin of back; ; skin of abdomen; ; secondary oocyte; ; sexually immature organism; ; conjunctival fornix; ; cornea; ; lower respiratory tract; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; structural molecule activity ;
Cellular component	cytoplasm ; keratin filament ; extracellular exosome ; cytoskeleton ; intermediate filament ; cytosol ;
Biological process	intermediate filament organization ; hair follicle morphogenesis ; keratinization ; cornification ;
	Sources:Amigo / QuickGO
Orthologs
	112802
	56735
	ENSG00000139648
	ENSMUSG00000051879
	Q3SY84
	Q9R0H5
	NM_033448
	NM_019956
	NP_258259
	NP_064340
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 10, 2023

KRT71 is a keratin gene. Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins.^[5]^[6] This gene encodes a protein that is expressed in the inner root sheath of hair follicles.^[6] The type II keratins are clustered in a region of chromosome 12q13.^[6]^[7]

Related Research Articles

Keratin 6A is one of the 27 different type II keratins expressed in humans. Keratin 6A was the first type II keratin sequence determined. Analysis of the sequence of this keratin together with that of the first type I keratin led to the discovery of the four helical domains in the central rod of keratins. In humans Keratin 6A is encoded by the KRT6A gene.

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.

Keratin 3 also known as cytokeratin 3 is a protein that in humans is encoded by the KRT3 gene. Keratin 3 is a type II cytokeratin. It is specifically found in the corneal epithelium together with keratin 12.

Keratin 13 is a protein that in humans is encoded by the KRT13 gene.

Keratin 12 is a protein that in humans is encoded by the KRT12 gene.

Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin 19 is a type I keratin.

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.

Keratin, type I cuticular Ha1 is a protein that in humans is encoded by the KRT31 gene.

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.

Keratin, type I cuticular Ha3-II is a protein that in humans is encoded by the KRT33B gene.

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.

Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.

Keratin 83, also known as KRT83, is a protein which humans is encoded by the KRT83 gene.

Keratin 80, also known as KRT80, is a protein which humans is encoded by the KRT80 gene.

Keratin 79 also known as KRT79 is a protein which humans is encoded by the KRT79 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000139648 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051879 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ho M, Thompson B, Fisk JN, Nebert DW, Bruford EA, Vasiliou V, Bunick CG (January 2022). "Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders". Human Genomics. 16 (1): 1. doi: 10.1186/s40246-021-00374-9 . PMC 8733776 . PMID 34991727.
1 2 3 Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC 2064177 . PMID 16831889.
↑ "KRT71 Gene symbol report". HUGO Gene Nomenclature Committee. Retrieved 2023-05-01.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000139648 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051879 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Ho M, Thompson B, Fisk JN, Nebert DW, Bruford EA, Vasiliou V, Bunick CG (January 2022). "Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders". Human Genomics. 16 (1): 1. doi: 10.1186/s40246-021-00374-9 . PMC 8733776 . PMID 34991727.

[Schweizer_2006-6] 1 2 3 Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC 2064177 . PMID 16831889.

[7] "KRT71 Gene symbol report". HUGO Gene Nomenclature Committee. Retrieved 2023-05-01.

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