DYNC1LI2

DYNC1LI2
Identifiers
Aliases	DYNC1LI2 , DNCLI2, LIC2, dynein cytoplasmic 1 light intermediate chain 2
External IDs	OMIM: 611406 MGI: 107738 HomoloGene: 4474 GeneCards: DYNC1LI2
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 66,720,893 bp [1] End 66,751,609 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 D3|8 53.04 cM Start 105,144,312 bp [2] End 105,169,679 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell inferior ganglion of vagus nerve subthalamic nucleus external globus pallidus internal globus pallidus Brodmann area 23 superior vestibular nucleus pons ventral tegmental area middle temporal gyrus Top expressed in hand globus pallidus superior frontal gyrus cerebellar cortex inferior colliculus medial geniculate nucleus pontine nuclei medial dorsal nucleus ventral tegmental area lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule motor activity nucleotide binding cytoskeletal motor activity ATP binding dynein heavy chain binding Cellular component cytoplasm cytosol membrane dynein complex microtubule cytoskeleton cytoplasmic dynein complex kinetochore lysosome late endosome centrosome Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II centrosome localization endoplasmic reticulum to Golgi vesicle-mediated transport microtubule cytoskeleton organization microtubule-based movement sister chromatid cohesion transport protein homooligomerization cellular response to nerve growth factor stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1783 234663 Ensembl ENSG00000135720 ENSMUSG00000035770 UniProt O43237 Q6PDL0 RefSeq (mRNA) NM_001286157 NM_006141 NM_001323955 NM_001013380 RefSeq (protein) NP_001273086 NP_001310884 NP_006132 NP_006132.1 NP_001013398 Location (UCSC) Chr 16: 66.72 – 66.75 Mb Chr 8: 105.14 – 105.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cytoplasmic dynein 1 light intermediate chain 2 is a protein that in humans is encoded by the DYNC1LI2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000135720 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035770 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC   2171247 . PMID   16260502.
6. "Entrez Gene: DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2".

Further reading

• Hughes SM, Vaughan KT, Herskovits JS, Vallee RB (1995). "Molecular analysis of a cytoplasmic dynein light intermediate chain reveals homology to a family of ATPases". J. Cell Sci. 108 (1): 17–24. doi:10.1242/jcs.108.1.17. PMID   7738094.
• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC   378590 . PMID   12417987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.