MAP1B

Last updated
MAP1B
Identifiers
Aliases MAP1B , FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B, PVNH9
External IDs OMIM: 157129 MGI: 1306778 HomoloGene: 38111 GeneCards: MAP1B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005909
NM_032010
NM_001324255

NM_008634

RefSeq (protein)

NP_001311184
NP_005900

NP_032660

Location (UCSC) Chr 5: 72.11 – 72.21 Mb Chr 13: 99.42 – 99.52 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene. [5] [6]

Contents

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described. [6]

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A [7] and RASSF1. [8]

Related Research Articles

Hippocalcin

Hippocalcin is a protein that in humans is encoded by the HPCA gene.

RASSF1

Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.

Microtubule-associated protein 2

Microtubule-associated protein 2 is a protein that in humans is encoded by the MAP2 gene.

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ANP32A gene. It is one of the targets of an oncomiR, MIRN21.

SPTAN1

Alpha II-spectrin, also known as Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene. Alpha II-spectrin is expressed in a variety of tissues, and is highly expressed in cardiac muscle at Z-disc structures, costameres and at the sarcolemma membrane. Mutations in alpha II-spectrin have been associated with early infantile epileptic encephalopathy-5, and alpha II-spectrin may be a valuable biomarker for Guillain–Barré syndrome and infantile congenital heart disease.

Nuclear mitotic apparatus protein 1

Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.

TUBA1A

Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1A gene.

TUBA1B

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.

MAP1A

Microtubule-associated protein 1A is a protein that in humans is encoded by the MAP1A gene.

KIF23

Kinesin-like protein KIF23 is a protein that in humans is encoded by the KIF23 gene.

KLC1 Gene of the kinesin light chain family

Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene.

MAP1LC3A

Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene. Two transcript variants encoding different isoforms have been found for this gene.

NRCAM

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.

KIF2C

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

TUBA8

Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene.

DLGAP1

Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.

MAP7

Ensconsin is a protein that in humans is encoded by the MAP7 gene.

MAPRE3

Microtubule-associated protein RP/EB family member 3 is a protein that in humans is encoded by the MAPRE3 gene.

MAP1S

Microtubule-associated protein 1S is a protein that in humans is encoded by the MAP1S gene.

KIF2A

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000131711 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052727 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. Bibcode:1991PNAS...88.7873L. doi: 10.1073/pnas.88.17.7873 . PMC   52406 . PMID   1881920.
  6. 1 2 "Entrez Gene: MAP1B microtubule-associated protein 1B".
  7. Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (Sep 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi: 10.1074/jbc.M302785200 . PMID   12807913.
  8. Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi: 10.1158/0008-5472.CAN-04-0267 . PMID   15205320.

Further reading