Acidic leucine-rich nuclear phosphoprotein 32 family member A

ANP32A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JE0, 2JE1, 4XOS
Identifiers
Aliases	ANP32A , C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32, acidic nuclear phosphoprotein 32 family member A
External IDs	OMIM: 600832; MGI: 108447; HomoloGene: 133783; GeneCards: ANP32A; OMA:ANP32A - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q23 Start 68,778,535 bp [1] End 68,820,897 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 B|9 33.68 cM Start 62,248,575 bp [2] End 62,286,094 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone monocyte paraflocculus of cerebellum middle frontal gyrus rectum blood C1 segment inferior ganglion of vagus nerve granulocyte Top expressed in neural layer of retina tail of embryo genital tubercle ventricular zone granulocyte maxillary prominence dentate gyrus of hippocampal formation granule cell mandibular prominence superior frontal gyrus migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding histone binding Cellular component cytoplasm perinuclear region of cytoplasm endoplasmic reticulum nucleus nucleoplasm Biological process intracellular signal transduction regulation of transcription, DNA-templated nucleocytoplasmic transport transcription, DNA-templated regulation of mRNA stability nucleosome assembly regulation of apoptotic process histone exchange Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8125 11737 Ensembl ENSG00000140350 ENSMUSG00000032249 UniProt P39687 O35381 RefSeq (mRNA) NM_006305 NM_009672 RefSeq (protein) NP_006296 NP_033802 Location (UCSC) Chr 15: 68.78 – 68.82 Mb Chr 9: 62.25 – 62.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ANP32A gene. ^{[5] [6] [7]} It is one of the targets of an oncomiR, MIRN21.

Interactions

Acidic leucine-rich nuclear phosphoprotein 32 family member A has been shown to interact with MAP1B, ^[8] TAF1A ^[9] and Protein SET. ^{[9] [10]}

See also

• ANP32B, ANP32C, ANP32D, ANP32E

References

1. GRCh38: Ensembl release 89: ENSG00000140350 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032249 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen TH, Brody JR, Romantsev FE, Yu JG, Kayler AE, Voneiff E, Kuhajda FP, Pasternack GR (March 1997). "Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci". Mol Biol Cell. 7 (12): 2045–56. doi:10.1091/mbc.7.12.2045. PMC   276049 . PMID   8970164.
6. Ulitzur N, Humbert M, Pfeffer SR (June 1997). "Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules". Proc Natl Acad Sci U S A. 94 (10): 5084–9. Bibcode:1997PNAS...94.5084U. doi: 10.1073/pnas.94.10.5084 . PMC   24635 . PMID   9144194.
7. "Entrez Gene: ANP32A Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A".
8. Opal P, Garcia Jesus J, Propst Friedrich, Matilla Antoni, Orr Harry T, Zoghbi Huda Y (September 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi: 10.1074/jbc.M302785200 . ISSN   0021-9258. PMID   12807913.
9. Seo SB, McNamara P, Heo S, Turner A, Lane W S, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi: 10.1016/S0092-8674(01)00196-9 . ISSN   0092-8674. PMID   11163245.
10. Fan Z, Beresford Paul J, Zhang Dong, Lieberman Judy (April 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Mol. Cell. Biol. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. ISSN   0270-7306. PMC   133744 . PMID   11909973.

Further reading

• Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats". Cerebellum. 4 (1): 7–18. doi:10.1080/14734220410019020. PMID   15895553. S2CID   39153579.
• Schraven B, Kirchgessner H, Gaber B, et al. (1991). "A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and pp32, a possible common substrate". Eur. J. Immunol. 21 (10): 2469–77. doi:10.1002/eji.1830211025. PMID   1655467. S2CID   24230538.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Vaesen M, Barnikol-Watanabe S, Götz H, et al. (1994). "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII". Biol. Chem. Hoppe-Seyler. 375 (2): 113–26. doi:10.1515/bchm3.1994.375.2.113. PMID   8192856.
• Fink TM, Vaesen M, Kratzin HD, et al. (1996). "Localization of the gene encoding the putative human HLA class II associated protein (PHAPI) to chromosome 15q22.3-q23 by fluorescence in situ hybridization". Genomics. 29 (1): 309–10. doi:10.1006/geno.1995.1257. PMID   8530098.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Li M, Makkinje A, Damuni Z (1996). "Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A". Biochemistry. 35 (22): 6998–7002. doi:10.1021/bi960581y. PMID   8679524.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Matilla A, Koshy BT, Cummings CJ, et al. (1997). "The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1". Nature. 389 (6654): 974–8. Bibcode:1997Natur.389..974M. doi:10.1038/40159. PMID   9353121. S2CID   4383708.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Kadkol SS, Brody JR, Pevsner J, et al. (1999). "Modulation of oncogenic potential by alternative gene use in human prostate cancer". Nat. Med. 5 (3): 275–9. doi:10.1038/6488. PMID   10086381. S2CID   24559649.
• Brody JR, Kadkol SS, Mahmoud MA, et al. (1999). "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32". J. Biol. Chem. 274 (29): 20053–5. doi: 10.1074/jbc.274.29.20053 . PMID   10400610.
• Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". J. Cell Biol. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC   2189805 . PMID   11018049.
• Seo SB, McNamara P, Heo S, et al. (2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi: 10.1016/S0092-8674(01)00196-9 . PMID   11163245.
• Bai J, Brody JR, Kadkol SS, Pasternack GR (2001). "Tumor suppression and potentiation by manipulation of pp32 expression". Oncogene. 20 (17): 2153–60. doi: 10.1038/sj.onc.1204294 . PMID   11360199.
• Beresford PJ, Zhang D, Oh DY, et al. (2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks". J. Biol. Chem. 276 (46): 43285–93. doi: 10.1074/jbc.M108137200 . PMID   11555662.
• Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–901. Bibcode:2001Sci...294.1895G. doi:10.1126/science.1064693. PMID   11729309. S2CID   43726887.

External links

• Human ANP32A genome location and ANP32A gene details page in the UCSC Genome Browser .