ANP32D

Last updated
ANP32D
Identifiers
Aliases ANP32D , PP32R2, acidic nuclear phosphoprotein 32 family member D
External IDs OMIM: 606878 GeneCards: ANP32D
Orthologs
SpeciesHumanMouse
Entrez

23519

n/a

Ensembl

ENSG00000139223

n/a

UniProt

O95626

n/a

RefSeq (mRNA)

NM_012404

n/a

RefSeq (protein)

NP_036536

n/a

Location (UCSC) Chr 12: 48.47 – 48.47 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Acidic leucine-rich nuclear phosphoprotein 32 family member D is a protein that in humans is encoded by the ANP32D gene. [3] [4] [5]

Contents

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. [5]

See also

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000139223 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ Kadkol SS, Brody JR, Pevsner J, Bai J, Pasternack GR (Apr 1999). "Modulation of oncogenic potential by alternative gene use in human prostate cancer". Nat Med. 5 (3): 275–9. doi:10.1038/6488. PMID   10086381. S2CID   24559649.
  4. ↑ Brody JR, Kadkol SS, Mahmoud MA, Rebel JM, Pasternack GR (Aug 1999). "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32". J Biol Chem. 274 (29): 20053–5. doi: 10.1074/jbc.274.29.20053 . PMID   10400610.
  5. 1 2 "Entrez Gene: ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D".

Further reading


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