TAF1A

Last updated
TAF1A
Identifiers
Aliases TAF1A , MGC:17061, RAFI48, SL1, TAFI48, TATA-box binding protein associated factor, RNA polymerase I subunit A
External IDs OMIM: 604903 MGI: 109578 HomoloGene: 4155 GeneCards: TAF1A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001201536
NM_005681
NM_139352

NM_001277957
NM_001277958
NM_001277959
NM_021466

RefSeq (protein)

NP_001188465
NP_005672
NP_647603

NP_001264886
NP_001264887
NP_001264888
NP_067441

Location (UCSC) Chr 1: 222.56 – 222.59 Mb Chr 1: 183.17 – 183.19 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene. [5] [6]

Contents

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as selective factor 1 (SL1), binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified. [6]

Interactions

TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A [7] and Protein SET. [7]

Related Research Articles

TATA-binding protein Protein-coding gene in the species Homo sapiens

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

Transcription factor TFIIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. TFIIA is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TFIID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TFIIB, TFIIE, TFIIF, and TFIIH. Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.

TAF7

Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.

UBTF

Nucleolar transcription factor 1 is a protein that in humans is encoded by the UBTF gene.

TAF9 Protein-coding gene in the species Homo sapiens

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in humans is encoded by the TAF9 gene.

TAF12 Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.

TAF4

Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.

TAF2 Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

TAF10

Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the TAF10 gene.

TAF5

Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.

TAF11

Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 gene.

TAF15

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.

TAF13 Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 13 is a protein that in humans is encoded by the TAF13 gene.

TAF1C

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.

TAF6L

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L is an enzyme that in humans is encoded by the TAF6L gene.

SNAPC1

snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene.

TAF1B

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.

TAF9B Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene.

TAF4B

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.

Selective factor 1

Selective factor 1 is a transcription factor that binds to the promoter of genes and recruits a preinitiation complex to which RNA polymerase I will bind to and begin the transcription of ribosomal RNA (rRNA).

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143498 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000072258 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (December 1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. Bibcode:1994Sci...266.1966C. doi:10.1126/science.7801123. PMID   7801123.
  6. 1 2 "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa".
  7. 1 2 Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi: 10.1016/S0092-8674(01)00196-9 . PMID   11163245. S2CID   11144887.

Further reading