TAF1A

TAF1A
Identifiers
Aliases	TAF1A , MGC:17061, RAFI48, SL1, TAFI48, TATA-box binding protein associated factor, RNA polymerase I subunit A
External IDs	OMIM: 604903; MGI: 109578; HomoloGene: 4155; GeneCards: TAF1A; OMA:TAF1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q41 Start 222,557,902 bp [1] End 222,589,933 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H5 Start 183,170,325 bp [2] End 183,191,020 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte testicle ventricular zone gonad ganglionic eminence Achilles tendon monocyte lymph node stromal cell of endometrium Top expressed in primary oocyte zygote secondary oocyte neural layer of retina Ileal epithelium spermatocyte ventricular zone Paneth cell medullary collecting duct morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding Cellular component microtubule cytoskeleton RNA polymerase I transcription regulator complex nucleus nucleoplasm Biological process transcription initiation from RNA polymerase I promoter transcription by RNA polymerase I termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9015 21339 Ensembl ENSG00000143498 ENSMUSG00000072258 UniProt Q15573 Q5JRA7 P97357 RefSeq (mRNA) NM_001201536 NM_005681 NM_139352 NM_001277957 NM_001277958 NM_001277959 NM_021466 RefSeq (protein) NP_001188465 NP_005672 NP_647603 NP_001264886 NP_001264887 NP_001264888 NP_067441 Location (UCSC) Chr 1: 222.56 – 222.59 Mb Chr 1: 183.17 – 183.19 Mb PubMed search [3] [4]
Wikidata
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TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene. ^{[5] [6]}

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as selective factor 1 (SL1), binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified. ^[6]

Interactions

TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A ^[7] and Protein SET. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000143498 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000072258 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (December 1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. Bibcode:1994Sci...266.1966C. doi:10.1126/science.7801123. PMID   7801123.
6. "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa".
7. Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi: 10.1016/S0092-8674(01)00196-9 . PMID   11163245. S2CID   11144887.

Further reading

• Rudloff U, Eberhard D, Tora L, Stunnenberg H, Grummt I (1994). "TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription". EMBO J. 13 (11): 2611–6. doi:10.1002/j.1460-2075.1994.tb06551.x. PMC   395135 . PMID   8013460.
• Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID   10894955. S2CID   27014629.
• Zhai W, Comai L (2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC   86070 . PMID   10913176.
• Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi: 10.1016/S0092-8674(01)00196-9 . PMID   11163245. S2CID   11144887.
• Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC   145519 . PMID   11250903.
• Dynes JL, Xu S, Bothner S, Lahti JM, Hori RT (2004). "The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors". J. Biochem. 135 (3): 429–38. doi:10.1093/jb/mvh051. PMID   15113842.
• Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC   434256 . PMID   15226435.
• Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID   15723054. S2CID   8913931.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.