Protein SET

SET
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E50
Identifiers
Aliases	SET , 2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA, SET nuclear proto-oncogene, MRD58
External IDs	OMIM: 600960; MGI: 1860267; HomoloGene: 55707; GeneCards: SET; OMA:SET - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.11 Start 128,683,424 bp [1] End 128,696,400 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 29,947,390 bp [2] End 29,962,589 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon ventricular zone epithelium of nasopharynx epithelium of colon germinal epithelium palpebral conjunctiva lymph node optic nerve parietal pleura Top expressed in tail of embryo epiblast abdominal wall migratory enteric neural crest cell morula ventricular zone embryo vas deferens primitive streak somite More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding histone binding protein binding protein phosphatase inhibitor activity protein phosphatase regulator activity Cellular component cytoplasm cytosol nucleoplasm endoplasmic reticulum perinuclear region of cytoplasm nucleus lipid droplet protein-containing complex Biological process negative regulation of neuron apoptotic process nucleosome assembly regulation of mRNA stability DNA replication nucleosome disassembly nucleocytoplasmic transport viral process negative regulation of transcription, DNA-templated negative regulation of histone acetylation negative regulation of catalytic activity regulation of catalytic activity negative regulation of phosphoprotein phosphatase activity regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6418 56086 Ensembl ENSG00000119335 ENSMUSG00000054766 UniProt Q01105 Q9EQU5 RefSeq (mRNA) NM_001122821 NM_001248000 NM_001248001 NM_003011 NM_001374326 NM_001204875 NM_023871 RefSeq (protein) NP_001116293 NP_001234929 NP_001234930 NP_003002 NP_001361255 NP_001191804 NP_076360 Location (UCSC) Chr 9: 128.68 – 128.7 Mb Chr 2: 29.95 – 29.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein SET, also known as Protein SET 1, is a protein that in humans is encoded by the SET gene. ^{[5] [6] [7]}

Interactions

Protein SET has been shown to interact with:

• Acidic leucine-rich nuclear phosphoprotein 32 family member A, ^{[8] [9]}
• CDK5R1, ^[10]
• KLF5, ^[11]
• NME1, ^[12] and
• TAF1A. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000119335 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054766 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Molecular and Cellular Biology. 12 (8): 3346–55. doi:10.1128/mcb.12.8.3346. PMC   364582 . PMID   1630450.
6. Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". The Journal of Biological Chemistry. 271 (19): 11059–62. doi: 10.1074/jbc.271.19.11059 . PMID   8626647.
7. "Entrez Gene: SET SET translocation (myeloid leukemia-associated)".
8. Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi: 10.1016/s0092-8674(01)00196-9 . PMID   11163245. S2CID   11144887.
9. Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/mcb.22.8.2810-2820.2002. PMC   133744 . PMID   11909973.
10. Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi: 10.1074/jbc.M107270200 . hdl: 10536/DRO/DU:30101408 . PMID   11741927.
11. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/mcb.23.23.8528-8541.2003. PMC   262669 . PMID   14612398.
12. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell. 112 (5): 659–72. doi: 10.1016/s0092-8674(03)00150-8 . PMID   12628186. S2CID   14019153.

Further reading

• Nagata K, Kawase H, Handa H, Yano K, Yamasaki M, Ishimi Y, Okuda A, Kikuchi A, Matsumoto K (May 1995). "Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis". Proceedings of the National Academy of Sciences of the United States of America. 92 (10): 4279–83. Bibcode:1995PNAS...92.4279N. doi: 10.1073/pnas.92.10.4279 . PMC   41927 . PMID   7753797.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Adachi Y, Pavlakis GN, Copeland TD (Mar 1994). "Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia". FEBS Letters. 340 (3): 231–5. Bibcode:1994FEBSL.340..231A. doi: 10.1016/0014-5793(94)80144-4 . PMID   8131851. S2CID   36974869.
• Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N (Feb 1994). "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII". Biological Chemistry Hoppe-Seyler. 375 (2): 113–26. doi:10.1515/bchm3.1994.375.2.113. PMID   8192856.
• Adachi Y, Pavlakis GN, Copeland TD (Jan 1994). "Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia". The Journal of Biological Chemistry. 269 (3): 2258–62. doi: 10.1016/S0021-9258(17)42162-4 . PMID   8294483.
• Adler HT, Nallaseth FS, Walter G, Tkachuk DC (Nov 1997). "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A". The Journal of Biological Chemistry. 272 (45): 28407–14. doi: 10.1074/jbc.272.45.28407 . PMID   9353299.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Carlson SG, Eng E, Kim EG, Perlman EJ, Copeland TD, Ballermann BJ (Oct 1998). "Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor". Journal of the American Society of Nephrology. 9 (10): 1873–80. doi: 10.1681/ASN.V9101873 . PMID   9773788.
• Brennan CM, Gallouzi IE, Steitz JA (Oct 2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". The Journal of Cell Biology. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC   2189805 . PMID   11018049.
• Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (Dec 2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Molecular and Cellular Biology. 20 (23): 8933–43. doi:10.1128/MCB.20.23.8933-8943.2000. PMC   86548 . PMID   11073993.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi: 10.1016/S0092-8674(01)00196-9 . PMID   11163245. S2CID   11144887.
• Minakuchi M, Kakazu N, Gorrin-Rivas MJ, Abe T, Copeland TD, Ueda K, Adachi Y (Mar 2001). "Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET" (PDF). European Journal of Biochemistry. 268 (5): 1340–51. doi: 10.1046/j.1432-1327.2001.02000.x . hdl:2433/150179. PMID   11231286.
• Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J (Nov 2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks". The Journal of Biological Chemistry. 276 (46): 43285–93. doi: 10.1074/jbc.M108137200 . PMID   11555662.
• Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi: 10.1074/jbc.M107270200 . hdl: 10536/DRO/DU:30101408 . PMID   11741927.
• Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. PMC   133744 . PMID   11909973.
• Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M (Jul 2002). "The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing". The Journal of Biological Chemistry. 277 (28): 25026–31. doi: 10.1074/jbc.M202256200 . PMID   11978794.