NME1

NME1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JXV, 1UCN, 2HVD, 2HVE, 3L7U, 4ENO
Identifiers
Aliases	NME1 , AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1, NME/NM23 nucleoside diphosphate kinase 1
External IDs	OMIM: 156490; MGI: 97355; HomoloGene: 128514; GeneCards: NME1; OMA:NME1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.33 Start 51,153,559 bp [1] End 51,162,428 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 D Start 93,847,805 bp [2] End 93,859,347 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex hypothalamus Brodmann area 9 superior frontal gyrus islet of Langerhans ganglionic eminence right frontal lobe hippocampus proper primary visual cortex cingulate gyrus Top expressed in right kidney epiblast neural tube proximal tubule embryo embryo ganglionic eminence dentate gyrus of hippocampal formation granule cell morula blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding deoxyribonuclease activity ribosomal small subunit binding GTP binding metal ion binding kinase activity protein binding identical protein binding ATP binding magnesium ion binding nucleoside diphosphate kinase activity RNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding single-stranded DNA binding intermediate filament binding enzyme binding protein kinase binding gamma-tubulin binding Cellular component ruffle membrane extracellular exosome nucleus cytoplasm mitochondrial outer membrane centrosome cytosol intermediate filament membrane perinuclear region of cytoplasm mitochondrion myelin sheath Biological process UTP biosynthetic process regulation of apoptotic process cell differentiation nucleobase-containing small molecule interconversion CTP biosynthetic process endocytosis phosphorylation positive regulation of epithelial cell proliferation nucleotide metabolic process nucleoside diphosphate phosphorylation nervous system development positive regulation of DNA binding GTP biosynthetic process negative regulation of cell population proliferation DNA metabolic process negative regulation of myeloid leukocyte differentiation negative regulation of gene expression positive regulation of neuron projection development response to amine hippocampus development response to testosterone response to cAMP cellular response to glucose stimulus cellular response to fatty acid lactation mammary gland development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4830 18102 Ensembl ENSG00000239672 ENSMUSG00000037601 UniProt P15531 P15532 RefSeq (mRNA) NM_198175 NM_000269 NM_008704 NM_001378854 RefSeq (protein) NP_000260 NP_937818 NP_032730 NP_001365783 Location (UCSC) Chr 17: 51.15 – 51.16 Mb Chr 11: 93.85 – 93.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

For the radio station, see NME Radio.

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. ^[5] It is thought to be a metastasis suppressor.

Function

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product. ^[6]

A bioinformatics study published in 2023 suggested that the NME1 gene might have a prognostic role in neuroblastoma. ^[7]

Interactions

NME1 has been shown to interact with:

• Aurora A kinase, ^[8]
• CD29 ^[9]
• NME3, ^{[10] [11]}
• Protein SET, ^[12]
• RAR-related orphan receptor alpha, ^[13]
• RAR-related orphan receptor beta, ^[13] and
• TERF1. ^[14]

See also

• Nucleoside-diphosphate kinase

References

1. GRCh38: Ensembl release 89: ENSG00000239672 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037601 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dooley S, Seib T, Engel M, Theisinger B, Janz H, Piontek K, Zang KD, Welter C (February 1994). "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1". Hum. Genet. 93 (1): 63–6. doi:10.1007/bf00218915. PMID   8270257. S2CID   6373221.
6. "Entrez Gene: NME1 non-metastatic cells 1, protein (NM23A) expressed in".
7. Chicco, Davide; Sanavia, Tiziana; Jurman, Giuseppe (4 March 2023). "Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma". BioData Mining. 16 (1): 7. doi: 10.1186/s13040-023-00325-1 . eISSN   1756-0381. PMC   9985261 . PMID   36870971.
8. Du J, Hannon GJ (December 2002). "The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1". Nucleic Acids Res. 30 (24): 5465–75. doi:10.1093/nar/gkf678. PMC   140054 . PMID   12490715.
9. Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C (June 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. 277 (23): 20895–902. doi: 10.1074/jbc.M200200200 . PMID   11919189.
10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
11. Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi: 10.1038/sj.cdd.4400720 . hdl: 11380/695506 . PMID   11042679.
12. Chakravarti D, Hong R (March 2003). "SET-ting the stage for life and death". Cell. 112 (5): 589–91. doi: 10.1016/s0092-8674(03)00151-x . PMID   12628178. S2CID   16423565.
13. Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID   8858107.
14. Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (February 1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID   9480811.

Further reading

• Freije JM, MacDonald NJ, Steeg PS (1998). "Nm23 and tumour metastasis: basic and translational advances". Biochem. Soc. Symp. 63: 261–71. PMID   9513729.
• Roymans D, Willems R, Van Blockstaele DR, Slegers H (2002). "Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis". Clin. Exp. Metastasis. 19 (6): 465–76. doi:10.1023/A:1020396722860. PMID   12405283. S2CID   21876557.
• Tee YT, Chen GD, Lin LY, Ko JL, Wang PH (2006). "Nm23-H1: a metastasis-associated gene". Taiwan J Obstet Gynecol. 45 (2): 107–13. doi: 10.1016/S1028-4559(09)60206-0 . PMID   17197349.
• Gilles AM, Presecan E, Vonica A, Lascu I (1991). "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme". J. Biol. Chem. 266 (14): 8784–9. doi: 10.1016/S0021-9258(18)31515-1 . PMID   1851158.
• Leone A, McBride OW, Weston A, Wang MG, Anglard P, Cropp CS, Goepel JR, Lidereau R, Callahan R, Linehan WM (1991). "Somatic allelic deletion of nm23 in human cancer". Cancer Res. 51 (9): 2490–3. PMID   2015608.
• Hailat N, Keim DR, Melhem RF, Zhu XX, Eckerskorn C, Brodeur GM, Reynolds CP, Seeger RC, Lottspeich F, Strahler JR (1991). "High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification". J. Clin. Invest. 88 (1): 341–5. doi:10.1172/JCI115299. PMC   296039 . PMID   2056128.
• Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker E, Margulies IM, King CR, Liotta LA, Steeg PS (1989). "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development". Nature. 342 (6246): 177–80. Bibcode:1989Natur.342..177R. doi:10.1038/342177a0. PMID   2509941. S2CID   4340066.
• Wang L, Patel U, Ghosh L, Chen HC, Banerjee S (1993). "Mutation in the nm23 gene is associated with metastasis in colorectal cancer". Cancer Res. 53 (4): 717–20. PMID   7916650.
• Chang CL, Zhu XX, Thoraval DH, Ungar D, Rawwas J, Hora N, Strahler JR, Hanash SM, Radany E (1994). "Nm23-H1 mutation in neuroblastoma" (PDF). Nature. 370 (6488): 335–6. Bibcode:1994Natur.370..335C. doi:10.1038/370335a0. hdl: 2027.42/62612 . PMID   8047138. S2CID   4356706.
• MacDonald NJ, De la Rosa A, Benedict MA, Freije JM, Krutsch H, Steeg PS (1993). "A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential". J. Biol. Chem. 268 (34): 25780–9. doi: 10.1016/S0021-9258(19)74458-5 . PMID   8245015.
• Postel EH, Berberich SJ, Flint SJ, Ferrone CA (1993). "Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis". Science. 261 (5120): 478–80. Bibcode:1993Sci...261..478P. doi:10.1126/science.8392752. PMID   8392752.
• Sudbrak R, Golla A, Hogan K, Powers P, Gregg R, Du Chesne I, Lehmann-Horn F, Deufel T (1993). "Exclusion of malignant hyperthermia susceptibility (MHS) from a putative MHS2 locus on chromosome 17q and of the alpha 1, beta 1, and gamma subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect" (PDF). Hum. Mol. Genet. 2 (7): 857–62. doi:10.1093/hmg/2.7.857. PMID   8395939. S2CID   86750140. Archived from the original (PDF) on 2020-02-07.
• MacDonald NJ, Freije JM, Stracke ML, Manrow RE, Steeg PS (1996). "Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells". J. Biol. Chem. 271 (41): 25107–16. doi: 10.1074/jbc.271.41.25107 . PMID   8810265.
• Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID   8858107.
• Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID   9480811.
• Schaertl S, Konrad M, Geeves MA (1998). "Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis". J. Biol. Chem. 273 (10): 5662–9. doi: 10.1074/jbc.273.10.5662 . PMID   9488696.
• Willems R, Van Bockstaele DR, Lardon F, Lenjou M, Nijs G, Snoeck HW, Berneman ZN, Slegers H (1998). "Decrease in nucleoside diphosphate kinase (NDPK/nm23) expression during hematopoietic maturation". J. Biol. Chem. 273 (22): 13663–8. doi: 10.1074/jbc.273.22.13663 . PMID   9593706.
• Manda R, Kohno T, Matsuno Y, Takenoshita S, Kuwano H, Yokota J (1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display". Genomics. 61 (1): 5–14. doi:10.1006/geno.1999.5939. PMID   10512675.
• Chicco, Davide; Sanavia, Tiziana; Jurman, Giuseppe (4 March 2023). "Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma". BioData Mining. 16 (1): 7. doi: 10.1186/s13040-023-00325-1 . eISSN   1756-0381. PMC   9985261 . PMID   36870971.