NME3

NME3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZS6
Identifiers
Aliases	NME3 , DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2, NME/NM23 nucleoside diphosphate kinase 3
External IDs	OMIM: 601817; MGI: 1930182; HomoloGene: 20562; GeneCards: NME3; OMA:NME3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 1,770,320 bp [1] End 1,771,561 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 25,115,474 bp [2] End 25,116,496 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right hemisphere of cerebellum right adrenal gland left adrenal cortex right adrenal cortex right uterine tube canal of the cervix gastric mucosa left uterine tube muscle layer of sigmoid colon Top expressed in bone marrow pancreas adrenal gland islet of Langerhans urinary bladder embryo proximal tubule right kidney epiblast hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity nucleotide binding transferase activity protein binding ATP binding metal ion binding nucleoside diphosphate kinase activity Cellular component cytosol intracellular anatomical structure Biological process UTP biosynthetic process apoptotic process CTP biosynthetic process GTP biosynthetic process nucleotide metabolic process nucleoside diphosphate phosphorylation phosphorylation nucleobase-containing small molecule interconversion regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4832 79059 Ensembl ENSG00000103024 ENSMUSG00000073435 UniProt Q13232 Q9WV85 RefSeq (mRNA) NM_002513 NM_019730 RefSeq (protein) NP_002504 NP_062704 Location (UCSC) Chr 16: 1.77 – 1.77 Mb Chr 17: 25.12 – 25.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene. ^{[5] [6]}

Interactions

NME3 has been shown to interact with NME1 ^{[7] [8]} and NME2. ^{[8] [9]}

Clinical significance

Mutations in this gene have been associated with congenital hypotonia, hypoventilation and cerebellar histopathological alterations. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000103024 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073435 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B (March 1997). "Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family". Cancer Research. 57 (6): 1180–7. PMID   9067290.
6. "Entrez Gene: NME3 non-metastatic cells 3, protein expressed in".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
8. Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death and Differentiation. 7 (9): 843–50. doi: 10.1038/sj.cdd.4400720 . hdl: 11380/695506 . PMID   11042679.
9. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
10. Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF (December 2018). "Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder". Proceedings of the National Academy of Sciences of the United States of America. 116 (2): 566–574. doi: 10.1073/pnas.1818629116 . PMC   6329951 . PMID   30587587.

Further reading

• Venturelli D, Martinez R, Melotti P, Casella I, Peschle C, Cucco C, Spampinato G, Darzynkiewicz Z, Calabretta B (August 1995). "Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7435–9. Bibcode:1995PNAS...92.7435V. doi: 10.1073/pnas.92.16.7435 . PMC   41354 . PMID   7638209.
• Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death and Differentiation. 7 (9): 843–50. doi: 10.1038/sj.cdd.4400720 . hdl: 11380/695506 . PMID   11042679.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (February 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID   11157797.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL (March 2006). "p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling". Proceedings of the National Academy of Sciences of the United States of America. 103 (12): 4717–22. Bibcode:2006PNAS..103.4717S. doi: 10.1073/pnas.0600585103 . PMC   1450237 . PMID   16537434.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Carinci F, Arcelli D, Lo Muzio L, Francioso F, Valentini D, Evangelisti R, Volinia S, D'Angelo A, Meroni G, Zollo M, Pastore A, Ionna F, Mastrangelo F, Conti P, Tetè S (October 2007). "Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma". Translational Research. 150 (4): 233–45. doi:10.1016/j.trsl.2007.03.011. PMID   17900511.

External links

• Overview of all the structural information available in the PDB for UniProt : Q13232 (Nucleoside diphosphate kinase 3) at the PDBe-KB .