KRT33A

KRT33A
Identifiers
Aliases	KRT33A , HA3I, Ha-3I, K33A, KRTHA3A, Krt1-3, hHa3-I, keratin 33A
External IDs	OMIM: 602761; MGI: 1919138; HomoloGene: 135742; GeneCards: KRT33A; OMA:KRT33A - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.2 Start 41,346,092 bp [1] End 41,350,828 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 D Start 99,902,021 bp [2] End 99,907,038 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle mucosa of esophagus left testis right testis skin of abdomen vagina skin of leg minor salivary glands right lung ectocervix Top expressed in lip hair follicle skin of back dermis skin of external ear skin of abdomen sexually immature organism medial head of gastrocnemius muscle conjunctival fornix diencephalon More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity Cellular component intermediate filament extracellular space cytosol Biological process keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3883 71888 Ensembl ENSG00000261986 ENSG00000006059 ENSMUSG00000035592 UniProt O76009 Q8K0Y2 RefSeq (mRNA) NM_004138 NM_027983 RefSeq (protein) NP_004129 NP_082259 Location (UCSC) Chr 17: 41.35 – 41.35 Mb Chr 11: 99.9 – 99.91 Mb PubMed search [3] [4]
Wikidata
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Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene. ^{[5] [6] [7]}

The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q21.2 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, KRT33A (this gene) and KRT33B . ^[7]

References

1. ENSG00000006059 GRCh38: Ensembl release 89: ENSG00000261986, ENSG00000006059 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035592 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rogers MA, Schweizer J, Kreig T, Winter H (Nov 1995). "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms". Mol Biol Rep. 20 (3): 155–61. doi:10.1007/BF00990548. PMID   7565656. S2CID   24487602.
6. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC   2064177 . PMID   16831889.
7. "Entrez Gene: KRT33A keratin 33A".

Further reading

• Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S –59S. doi:10.1111/1523-1747.ep12362635. PMID   7686952.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Rogers MA, Winter H, Langbein L, et al. (2005). "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain". Differentiation. 72 (9–10): 527–40. doi:10.1111/j.1432-0436.2004.07209006.x. PMID   15617563.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi: 10.1074/jbc.274.28.19874 . PMID   10391933.
• Rogers MA, Winter H, Wolf C, et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J. Biol. Chem. 273 (41): 26683–91. doi: 10.1074/jbc.273.41.26683 . PMID   9756910.