KIF5C

KIF5C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VFV, 1VFW, 1VFX, 1VFZ, 3J6H, 3WRD, 3X2T
Identifiers
Aliases	KIF5C , CDCBM2, KINN, NKHC, NKHC-2, NKHC2, kinesin family member 5C
External IDs	OMIM: 604593; MGI: 1098269; HomoloGene: 56234; GeneCards: KIF5C; OMA:KIF5C - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q23.1-q23.2 Start 148,875,227 bp [1] End 149,026,759 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 C1.1|2 28.68 cM Start 49,509,310 bp [2] End 49,664,790 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 paraflocculus of cerebellum frontal pole cerebellar vermis middle temporal gyrus middle frontal gyrus Brodmann area 46 postcentral gyrus Brodmann area 23 orbitofrontal cortex Top expressed in globus pallidus substantia nigra cerebellar vermis lobe of cerebellum lateral geniculate nucleus dentate gyrus of hippocampal formation granule cell facial motor nucleus ventral tegmental area anterior amygdaloid area subiculum More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule motor activity nucleotide binding microtubule binding protein binding plus-end-directed microtubule motor activity ATP binding ATPase activity Cellular component cytoplasm kinesin complex ciliary rootlet neuron projection microtubule cytoskeleton dendrite dendrite cytoplasm cell projection soma axonal growth cone synapse distal axon axon cytoplasm Biological process protein localization cytoskeleton-dependent intracellular transport mRNA transport organelle organization axon guidance microtubule-based movement motor neuron axon guidance synaptic vesicle transport anterograde dendritic transport of neurotransmitter receptor complex anterograde axonal protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3800 16574 Ensembl ENSG00000168280 ENSG00000276734 ENSMUSG00000026764 UniProt O60282 P28738 RefSeq (mRNA) NM_004522 NM_008449 RefSeq (protein) NP_004513 NP_032475 Location (UCSC) Chr 2: 148.88 – 149.03 Mb Chr 2: 49.51 – 49.66 Mb PubMed search [3] [4]
Wikidata
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Kinesin heavy chain isoform 5C is a protein that in humans is encoded by the KIF5C gene. ^{[5] [6]} It is part of the kinesin family of motor proteins.

References

1. ENSG00000276734 GRCh38: Ensembl release 89: ENSG00000168280, ENSG00000276734 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026764 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Niclas J, Navone F, Hom-Booher N, Vale RD (Jun 1994). "Cloning and localization of a conventional kinesin motor expressed exclusively in neurons". Neuron. 12 (5): 1059–72. doi:10.1016/0896-6273(94)90314-X. PMID   7514426. S2CID   32927183.
6. "Entrez Gene: KIF5C kinesin family member 5C".

Further reading

• Engelender S, Sharp AH, Colomer V, et al. (1998). "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin". Hum. Mol. Genet. 6 (13): 2205–12. doi: 10.1093/hmg/6.13.2205 . PMID   9361024.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
• Xia Ch; Rahman A; Yang Z; Goldstein LS (1998). "Chromosomal localization reveals three kinesin heavy chain genes in mouse". Genomics. 52 (2): 209–13. doi:10.1006/geno.1998.5427. PMID   9782088.
• Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA (2001). "Kinesin light-chain KLC3 expression in testis is restricted to spermatids". Biol. Reprod. 64 (5): 1320–30. doi:10.1095/biolreprod64.5.1320. PMC   3161965 . PMID   11319135.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". J. Biol. Chem. 280 (15): 14723–32. doi: 10.1074/jbc.M409095200 . PMID   15644324.
• Smith MJ, Pozo K, Brickley K, Stephenson FA (2006). "Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes". J. Biol. Chem. 281 (37): 27216–28. doi: 10.1074/jbc.M600522200 . PMID   16835241.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Overview of all the structural information available in the PDB for UniProt : P28738 (Mouse Kinesin heavy chain isoform 5C) at the PDBe-KB .